KEGG   COMPOUND: C00788
Entry
C00788                      Compound                               
Name
L-Adrenaline;
(R)-(-)-Adrenaline;
(R)-(-)-Epinephrine;
(R)-(-)-Epirenamine;
(R)-(-)-Adnephrine;
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
Formula
C9H13NO3
Exact mass
183.0895
Mol weight
183.20
Structure
Remark
Same as: D00095
Reaction
R02533 R02919 R02920
Pathway
map00350  Tyrosine metabolism
map01100  Metabolic pathways
map02020  Two-component system
map02024  Quorum sensing
map04024  cAMP signaling pathway
map04080  Neuroactive ligand-receptor interaction
map04261  Adrenergic signaling in cardiomyocytes
map04923  Regulation of lipolysis in adipocytes
map04924  Renin secretion
map05207  Chemical carcinogenesis - receptor activation
Module
M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Network
nt06028  Dopamine and serotonin metabolism
nt06214  PI3K signaling (cancer)
nt06234  cAMP signaling (cancer)
Enzyme
1.4.3.4         2.1.1.6         2.1.1.28
Brite
Compounds with biological roles [BR:br08001]
 Hormones and transmitters
  Other hormones
   Adrenalines
    C00788  Adrenaline
  Neurotransmitters
   Biogenic amines
    C00788  Epinephrine; Adrenaline
Prodrugs [br08324.html]
 C00788
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AD Other agents for local oral treatment
     A01AD01 Epinephrine
      D00095  Epinephrine (USP/INN) <JP/US>
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BC Local hemostatics
     B02BC09 Epinephrine
      D00095  Epinephrine (USP/INN) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA24 Epinephrine
      D00095  Epinephrine (USP/INN) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA14 Epinephrine
      D00095  Epinephrine (USP/INN) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AA Alpha- and beta-adrenoreceptor agonists
     R03AA01 Epinephrine
      D00095  Epinephrine (USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA01 Epinephrine
      D00095  Epinephrine (USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Sympathomimetic
   Epinephrine
    D00095  Epinephrine (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2451  Epinephrines
     D00095  Epinephrine (USP/INN); Adrenaline (JP18)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Adrenaline (Epinephrine)
    D00095  Epinephrine (USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01703  Cardiotonic
   DG01699  Catecholamine cardiotonic
    DG00013  Epinephrine
     D00095  Epinephrine
  DG01456  Adrenergic receptor agonist
   DG00013  Epinephrine
    D00095  Epinephrine
  DG01951  Catecholamine adrenergic receptor agonist
   DG00013  Epinephrine
    D00095  Epinephrine
 Metabolizing enzyme substrate
  DG01592  COMT substrate
   DG00013  Epinephrine
    D00095  Epinephrine
  DG02917  MAO substrate
   DG00013  Epinephrine
    D00095  Epinephrine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00095  Epinephrine (USP/INN) <JP/US>
    ADRA2
     D00095  Epinephrine (USP/INN) <JP/US>
    ADRB
     D00095  Epinephrine (USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00095  Adrenaline
  D00095  Adrenaline solution
  D00095  Adrenaline injection
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00095
Prodrugs [br08324.html]
 D00095
Other DBs
CAS: 51-43-4
PubChem: 4046
ChEBI: 28918
KNApSAcK: C00029643
PDB-CCD: ALE[PDBj]
NIKKAJI: J9.224J
LinkDB
KCF data

ATOM        13
            1   C8y C    21.2028  -17.0133
            2   C8x C    21.2028  -18.4284
            3   C8x C    19.9857  -16.3144
            4   C1c C    22.4083  -16.3144
            5   C8x C    19.9857  -19.1389
            6   C8y C    18.7742  -17.0133
            7   C1b C    23.6196  -17.0075
            8   O1a O    22.4083  -14.9168
            9   C8y C    18.7742  -18.4284
            10  N1b N    24.8191  -16.3087
            11  O1a O    17.5630  -19.1156
            12  O1a O    17.5677  -16.3165
            13  C1a C    26.0284  -17.0006
BOND        13
            1     1   3 1
            2     1   4 1
            3     2   5 1
            4     3   6 2
            5     4   7 1
            6     4   8 1 #Up
            7     5   9 2
            8     7  10 1
            9     9  11 1
            10    6   9 1
            11    6  12 1
            12    1   2 2
            13   10  13 1

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