KEGG COMPOUND: C03259

COMPOUND: C03259

Entry

C03259                      Compound

Name

Coagulation factor IXa

Sequence

(Light chain)
YNSGKLEEFV QGNLERECME EKCSFEEARE VFENTERTTE FWKQYVDGDQ CESNPCLNGG
SCKDDINSYE CWCPFGFEGK NCELDVTCNI KNGRCEQFCK NSADNKVVCS CTEGYRLAEN
QKSCEPAVPF PCGRVSVSQT SKLTR
(Heavy chain)
VVGGEDAKPG QFPWQVVLNG KVDAFCGGSI VNEKWIVTAA HCVETGVKIT VVAGEHNIEE
TEHTEQKRNV IRIIPHHNYN AAINKYNHDI ALLELDEPLV LNSYVTPICI ADKEYTNIFL
KFGSGYVSGW GRVFHKGRSA LVLQYLRVPL VDRATCLRST KFTIYNNMFC AGFHEGGRDS
CQGDSGGPHV TEVEGTSFLT GIISWGEECA MKGKYGIYTK VSRYVNWIKE KTKLT
(Disulfude bridge) L132-H109

Organism

Homo sapiens [HSA:2158]

Type

Peptide

Pathway

map04610

Complement and coagulation cascades

Network

nt06514 Coagulation cascade

Other DBs

PubChem:

6123

LinkDB

» Japanese version

COMPOUND: C04001

Entry

C04001                      Compound

Name

Coagulation factor VIIIa

Sequence

(Light chain)
EITRTTLQSD QEEIDYDDTI SVEMKKEDFD IYDEDENQSP RSFQKKTRHY FIAAVERLWD
YGMSSSPHVL RNRAQSGSVP QFKKVVFQEF TDGSFTQPLY RGELNEHLGL LGPYIRAEVE
DNIMVTFRNQ ASRPYSFYSS LISYEEDQRQ GAEPRKNFVK PNETKTYFWK VQHHMAPTKD
EFDCKAWAYF SDVDLEKDVH SGLIGPLLVC HTNTLNPAHG RQVTVQEFAL FFTIFDETKS
WYFTENMERN CRAPCNIQME DPTFKENYRF HAINGYIMDT LPGLVMAQDQ RIRWYLLSMG
SNENIHSIHF SGHVFTVRKK EEYKMALYNL YPGVFETVEM LPSKAGIWRV ECLIGEHLHA
GMSTLFLVYS NKCQTPLGMA SGHIRDFQIT ASGQYGQWAP KLARLHYSGS INAWSTKEPF
SWIKVDLLAP MIIHGIKTQG ARQKFSSLYI SQFIIMYSLD GKKWQTYRGN STGTLMVFFG
NVDSSGIKHN IFNPPIIARY IRLHPTHYSI RSTLRMELMG CDLNSCSMPL GMESKAISDA
QITASSYFTN MFATWSPSKA RLHLQGRSNA WRPQVNNPKE WLQVDFQKTM KVTGVTTQGV
KSLLTSMYVK EFLISSSQDG HQWTLFFQNG KVKVFQGNQD SFTPVVNSLD PPLLTRYLRI
HPQSWVHQIA LRMEVLGCEA QDLY
(Heavy chain)
ATRRYYLGAV ELSWDYMQSD LGELPVDARF PPRVPKSFPF NTSVVYKKTL FVEFTDHLFN
IAKPRPPWMG LLGPTIQAEV YDTVVITLKN MASHPVSLHA VGVSYWKASE GAEYDDQTSQ
REKEDDKVFP GGSHTYVWQV LKENGPMASD PLCLTYSYLS HVDLVKDLNS GLIGALLVCR
EGSLAKEKTQ TLHKFILLFA VFDEGKSWHS ETKNSLMQDR DAASARAWPK MHTVNGYVNR
SLPGLIGCHR KSVYWHVIGM GTTPEVHSIF LEGHTFLVRN HRQASLEISP ITFLTAQTLL
MDLGQFLLFC HISSHQHDGM EAYVKVDSCP EEPQLRMKNN EEAEDYDDDL TDSEMDVVRF
DDDNSPSFIQ IRSVAKKHPK TWVHYIAAEE EDWDYAPLVL APDDRSYKSQ YLNNGPQRIG
RKYKKVRFMA YTDETFKTRE AIQHESGILG PLLYGEVGDT LLIIFKNQAS RPYNIYPHGI
TDVRPLYSRR LPKGVKHLKD FPILPGEIFK YKWTVTVEDG PTKSDPRCLT RYYSSFVNME
RDLASGLIGP LLICYKESVD QRGNQIMSDK RNVILFSVFD ENRSWYLTEN IQRFLPNPAG
VQLEDPEFQA SNIMHSINGY VFDSLQLSVC LHEVAYWYIL SIGAQTDFLS VFFSGYTFKH
KMVYEDTLTL FPFSGETVFM SMENPGLWIL GCHNSDFRNR GMTALLKVSS CDKNTGDYYE
DSYEDISAYL LSKNNAIEPR SFSQNSRHPS TRQKQFNATT IPENDIEKTD PWFAHRTPMP
KIQNVSSSDL LMLLRQSPTP HGLSLSDLQE AKYETFSDDP SPGAIDSNNS LSEMTHFRPQ
LHHSGDMVFT PESGLQLRLN EKLGTTAATE LKKLDFKVSS TSNNLISTIP SDNLAAGTDN
TSSLGPPSMP VHYDSQLDTT LFGKKSSPLT ESGGPLSLSE ENNDSKLLES GLMNSQESSW
GKNVSSTESG RLFKGKRAHG PALLTKDNAL FKVSISLLKT NKTSNNSATN RKTHIDGPSL
LIENSPSVWQ NILESDTEFK KVTPLIHDRM LMDKNATALR LNHMSNKTTS SKNMEMVQQK
KEGPIPPDAQ NPDMSFFKML FLPESARWIQ RTHGKNSLNS GQGPSPKQLV SLGPEKSVEG
QNFLSEKNKV VVGKGEFTKD VGLKEMVFPS SRNLFLTNLD NLHENNTHNQ EKKIQEEIEK
KETLIQENVV LPQIHTVTGT KNFMKNLFLL STRQNVEGSY DGAYAPVLQD FRSLNDSTNR
TKKHTAHFSK KGEEENLEGL GNQTKQIVEK YACTTRISPN TSQQNFVTQR SKR

Organism

Homo sapiens [HSA:2157]

Type

Peptide

Pathway

map04610

Complement and coagulation cascades

Network

nt06514 Coagulation cascade

Other DBs

PubChem:

6714

LinkDB

» Japanese version

COMPOUND: C03378

Entry

C03378                      Compound

Name

Coagulation factor VIIa

Sequence

(Light chain)
ANAFLEELRP GSLERECKEE QCSFEEAREI FKDAERTKLF WISYSDGDQC ASSPCQNGGS
CKDQLQSYIC FCLPAFEGRN CETHKDDQLI CVNENGGCEQ YCSDHTGTKR SCRCHEGYSL
LADGVSCTPT VEYPCGKIPI LEKRNASKPQ GR
(Heavy chain)
IVGGKVCPKG ECPWQVLLLV NGAQLCGGTL INTIWVVSAA HCFDKIKNWR NLIAVLGEHD
LSEHDGDEQS RRVAQVIIPS TYVPGTTNHD IALLRLHQPV VLTDHVVPLC LPERTFSERT
LAFVRFSLVS GWGQLLDRGA TALELMVLNV PRLMTQDCLQ QSRKVGDSPN ITEYMFCAGY
SDGSKDSCKG DSGGPHATHY RGTWYLTGIV SWGQGCATVG HFGVYTRVSQ YIEWLQKLMR
SEPRPGVLLR APFP
(Disulfide bridge: L135-H110)

Organism

Homo sapiens [HSA:2155]

Type

Peptide

Remark

Same as:

D00172

Pathway

map04610

Complement and coagulation cascades

Network

nt06514 Coagulation cascade

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BD Blood coagulation factors
     B02BD05 Coagulation factor VII
      D00172  Eptacog alfa (INN) <JP/US>
     B02BD08 Coagulation factor VIIa
      D00172  Eptacog alfa (INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
6  Agents against pathologic organisms and parasites
  63  Biological preparations
   634  Human blood preparations
    6343  Plasma preparations
     D00172  Eptacog alfa (INN); Eptacog alfa (activated) (genetical recombination) (JAN)
Drug groups [BR:br08330]
Blood modifier agent
  DG02016  Hemostatics
   DG02014  Blood coagulation accelerant
    DG02013  Blood coagulation factor
     DG00172  Blood coagulation factor VII
      D00172  Eptacog alfa
Target-based classification of drugs [BR:br08310]
Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    F7a
     D00172  Eptacog alfa (INN) <JP/US>
New drug approvals in the USA [br08319.html]
Cellular and gene therapy products
  D00172
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D00172
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D00172
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D00172

Other DBs

PubChem:

6213

LinkDB

» Japanese version

Homo sapiens (human): 2152

Entry

2152              CDS       T01001

Symbol

F3, CD142, TF, TFA

Name

(RefSeq) coagulation factor III, tissue factor

K03901

coagulation factor III (tissue factor)

Organism

hsa Homo sapiens (human)

Pathway

hsa04610

Complement and coagulation cascades

hsa04933

AGE-RAGE signaling pathway in diabetic complications

Network

nt06514 Coagulation cascade

Element

N01503

Extrinsic pathway of coagulation cascade, F7 activation

N01510

Common pathway of coagulation cascade, F10 activation

Drug target

Tifacogin:

D06142

Tisotumab:

D11813

Tisotumab vedotin:

D11814<JP/US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    2152 (F3)
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    2152 (F3)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    2152 (F3)
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
    2152 (F3)
CD molecules [BR:hsa04090]
Proteins
  2152 (F3)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
Others
  2152 (F3)

SSDB

Motif

Pfam:

Tissue_fac Interfer-bind fn3_SORL1 KIAA1549 Baculo_11_kDa GBS104-like_Ig

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

1:complement(94529173..94541759)

AA seq 295 aa
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS

NT seq 888 nt +upstreamnt +downstreamnt
atggagacccctgcctggccccgggtcccgcgccccgagaccgccgtcgctcggacgctc
ctgctcggctgggtcttcgcccaggtggccggcgcttcaggcactacaaatactgtggca
gcatataatttaacttggaaatcaactaatttcaagacaattttggagtgggaacccaaa
cccgtcaatcaagtctacactgttcaaataagcactaagtcaggagattggaaaagcaaa
tgcttttacacaacagacacagagtgtgacctcaccgacgagattgtgaaggatgtgaag
cagacgtacttggcacgggtcttctcctacccggcagggaatgtggagagcaccggttct
gctggggagcctctgtatgagaactccccagagttcacaccttacctggagacaaacctc
ggacagccaacaattcagagttttgaacaggtgggaacaaaagtgaatgtgaccgtagaa
gatgaacggactttagtcagaaggaacaacactttcctaagcctccgggatgtttttggc
aaggacttaatttatacactttattattggaaatcttcaagttcaggaaagaaaacagcc
aaaacaaacactaatgagtttttgattgatgtggataaaggagaaaactactgtttcagt
gttcaagcagtgattccctcccgaacagttaaccggaagagtacagacagcccggtagag
tgtatgggccaggagaaaggggaattcagagaaatattctacatcattggagctgtggta
tttgtggtcatcatccttgtcatcatcctggctatatctctacacaagtgtagaaaggca
ggagtggggcagagctggaaggagaactccccactgaatgtttcataa

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