KEGG   DRUG: Naproxen
Entry
D00118                      Drug                                   
Name
Naproxen (JP18/USP/INN);
Naprosyn (TN)
Product
EC-NAPROXEN (Bryant Ranch Prepack), EC-NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Woodward Pharma Services LLC), NAPROXEN SODIUM (Canton Laboratories)
  Generic
NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (ANI Pharmaceuticals), NAPROXEN (Acella Pharmaceuticals), NAPROXEN (Advanced Rx Pharmacy of Tennessee), NAPROXEN (Advanced Rx Pharmacy of Tennessee), NAPROXEN (Advanced Rx of Tennessee), NAPROXEN (Advanced Rx of Tennessee), NAPROXEN (Advanced Rx of Tennessee), NAPROXEN (Advanced Rx of Tennessee), NAPROXEN (Advanced Rx of Tennessee), NAPROXEN (American Health Packaging), NAPROXEN (Amneal Pharmaceuticals LLC), NAPROXEN (Amneal Pharmaceuticals NY LLC), NAPROXEN (Amneal Pharmaceuticals of New York LLC), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Asclemed USA), NAPROXEN (Asclemed USA), NAPROXEN (Asclemed USA), NAPROXEN (Aurobindo Pharma Limited), NAPROXEN (AvPAK), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Camber Pharmaceuticals), NAPROXEN (Cameron Pharmaceuticals), NAPROXEN (Cipla USA), NAPROXEN (Cipla USA), NAPROXEN (DIRECT RX), NAPROXEN (Direct_Rx), NAPROXEN (Exelan Pharmaceuticals), NAPROXEN (Granules Pharmaceuticals), NAPROXEN (Hikma Pharmaceuticals USA), NAPROXEN (MARKSANS PHARMA LIMITED), NAPROXEN (McKesson Corporation dba SKY Packaging), NAPROXEN (Medsource Pharmaceuticals), NAPROXEN (NCS HealthCare of KY), NAPROXEN (Northwind Pharmaceuticals), NAPROXEN (Northwind Pharmaceuticals), NAPROXEN (Northwind Pharmaceuticals), NAPROXEN (Northwind Pharmaceuticals), NAPROXEN (Northwind Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (Pharmasource Meds), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (QPharma), NAPROXEN (QPharma), NAPROXEN (Quality Care Products), NAPROXEN (Quality Care Products), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (Radha Pharmaceuticals), NAPROXEN (RedPharm Drug), NAPROXEN (RedPharm Drug), NAPROXEN (RedPharm Drug), NAPROXEN (RedPharm Drug), NAPROXEN (Redpharm Drug), NAPROXEN (ST. MARY'S MEDICAL PARK PHARMACY), NAPROXEN (ST. MARY'S MEDICAL PARK PHARMACY), NAPROXEN (ScieGen Pharmaceuticals), NAPROXEN (St. Mary's Medical Park Pharmacy), NAPROXEN (St. Mary's Medical Park Pharmacy), NAPROXEN (TIME CAP LABORATORIES), NAPROXEN (Teva Pharmaceuticals USA), NAPROXEN (TruPharma LLC), NAPROXEN (Zydus Lifesciences Limited), NAPROXEN (Zydus Pharmaceuticals USA), NAPROXEN ORAL SUSPENSION (Novitium Pharma LLC), NAPROXEN SODIUM (Glenmark Pharmaceuticals)
Formula
C14H14O3
Exact mass
230.0943
Mol weight
230.26
Structure
Simcomp
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01908  Anti-inflammatory drug, propionic acid derivatives
Remark
Same as: C01517
Therapeutic category: 1149
ATC code: G02CC02 M01AE02 M02AA12
Chemical structure group: DG00455
Product (DG00455): D00118<JP/US> D00970<US>
Product (mixture): D11576<US>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
  Disease
Rheumatoid arthritis [DS:H00630]
Ankylosing spondylitis [DS:H01674]
Polyarticular juvenile idiopathic arthritis [DS:H01672]
Acute gout [DS:H01532]
Comment
Propionic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Structure map
map07048  Antimigraines
map07114  Naphthalene family
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CC Antiinflammatory products for vaginal administration
     G02CC02 Naproxen
      D00118  Naproxen (JP18/USP/INN) <JP/US>
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE02 Naproxen
      D00118  Naproxen (JP18/USP/INN) <JP/US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA12 Naproxen
      D00118  Naproxen (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Naproxen
    D00118  Naproxen (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00118  Naproxen (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Drugs requiring guidance
  New approved switch OTC drugs
   Naproxen
    D00118  Naproxen (JP18/USP/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01908  Anti-inflammatory drug, propionic acid derivatives
    DG00455  Naproxen
     D00118  Naproxen
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D00118  Naproxen
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00118  Naproxen (JP18/USP/INN) <JP/US>
    PTGS2 (COX2)
     D00118  Naproxen (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00118  Naproxen
Rx-to-OTC switch list in Japan [br08314.html]
 D00118
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01908  Anti-inflammatory drug, propionic acid derivatives
    DG00455  Naproxen
Other DBs
CAS: 22204-53-1
PubChem: 7847186
ChEBI: 7476
PDB-CCD: NPS[PDBj]
LigandBox: D00118
NIKKAJI: J9.289D
LinkDB
KCF data

ATOM        17
            1   C8y C    24.6254  -20.0866
            2   C8y C    24.6254  -21.4127
            3   C8x C    25.8119  -19.3887
            4   C8x C    23.5087  -19.3887
            5   C8x C    23.5087  -22.1106
            6   C8x C    25.8119  -22.1106
            7   C8y C    26.9983  -20.0866
            8   C8x C    22.3222  -20.0866
            9   C8y C    22.3222  -21.4127
            10  C8x C    26.9983  -21.3429
            11  C1c C    28.1848  -19.3887
            12  O2a O    21.1358  -22.1106
            13  C6a C    29.3015  -20.0866
            14  C1a C    28.1848  -18.0626
            15  C1a C    19.4607  -21.0637
            16  O6a O    30.6974  -19.1793
            17  O6a O    29.3015  -21.4127
BOND        18
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     5   9 2
            9     6  10 2
            10    7  11 1
            11    9  12 1
            12   11  13 1
            13   11  14 1 #Down
            14   12  15 1
            15   13  16 1
            16   13  17 2
            17    7  10 1
            18    8   9 1

» Japanese version   » Back

KEGG   DRUG: Naproxen sodium
Entry
D00970                      Drug                                   
Name
Naproxen sodium (USP);
Anaprox (TN)
Product
NAPRELAN (ALMATICA PHARMA)
  Generic
NAPROXEN (Granules India), NAPROXEN (Northwind Pharmaceuticals), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN SODIUM (A-S Medication Solutions), NAPROXEN SODIUM (Alvogen), NAPROXEN SODIUM (Amneal Pharmaceuticals of New York LLC), NAPROXEN SODIUM (Asclemed USA), NAPROXEN SODIUM (Aurobindo Pharma Limited), NAPROXEN SODIUM (AvPAK), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (Direct Rx), NAPROXEN SODIUM (Dr. Reddy's Laboratories), NAPROXEN SODIUM (NuCare Pharmaceuticals), NAPROXEN SODIUM (PD-Rx Pharmaceuticals), NAPROXEN SODIUM (PD-Rx Pharmaceuticals), NAPROXEN SODIUM (Preferred Pharmaceuticals), NAPROXEN SODIUM (Proficient Rx LP), NAPROXEN SODIUM (Proficient Rx LP), NAPROXEN SODIUM (Proficient Rx LP), NAPROXEN SODIUM (Quality Care Products), NAPROXEN SODIUM (REMEDYREPACK), NAPROXEN SODIUM (REMEDYREPACK), NAPROXEN SODIUM (SA3), NAPROXEN SODIUM (ST. MARY'S MEDICAL PARK PHARMACY), NAPROXEN SODIUM (ScieGen Pharmaceuticals), NAPROXEN SODIUM (Teva Pharmaceuticals), NAPROXEN SODIUM (Upsher-Smith Laboratories)
Formula
C14H13O3. Na
Exact mass
252.0762
Mol weight
252.24
Structure
Simcomp
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01908  Anti-inflammatory drug, propionic acid derivatives
Remark
ATC code: G02CC02 M01AE02 M02AA12
Chemical structure group: DG00455
Product (DG00455): D00118<JP/US> D00970<US>
Product (mixture): D11577<US>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
  Disease
Rheumatoid arthritis [DS:H00630]
Ankylosing spondylitis [DS:H01674]
Polyarticular juvenile idiopathic arthritis [DS:H01672]
Acute gout [DS:H01532]
Comment
Propionic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Structure map
map07048  Antimigraines
map07114  Naphthalene family
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CC Antiinflammatory products for vaginal administration
     G02CC02 Naproxen
      D00970  Naproxen sodium (USP) <US>
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE02 Naproxen
      D00970  Naproxen sodium (USP) <US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA12 Naproxen
      D00970  Naproxen sodium (USP) <US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Naproxen
    D00970  Naproxen sodium (USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01908  Anti-inflammatory drug, propionic acid derivatives
    DG00455  Naproxen
     D00970  Naproxen sodium
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D00970  Naproxen sodium
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00970  Naproxen sodium (USP) <US>
    PTGS2 (COX2)
     D00970  Naproxen sodium (USP) <US>
Rx-to-OTC switch list in the USA [br08315.html]
 D00970
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01908  Anti-inflammatory drug, propionic acid derivatives
    DG00455  Naproxen
Other DBs
CAS: 26159-34-2
PubChem: 7848033
ChEBI: 7477
LigandBox: D00970
NIKKAJI: J17.059C
LinkDB
KCF data

ATOM        18
            1   C8y C    23.5997  -20.0988
            2   C8y C    23.5997  -21.4993
            3   C8x C    24.7901  -19.3985
            4   C8x C    22.3393  -19.3985
            5   C8x C    22.3393  -22.1995
            6   C8x C    24.7901  -22.1995
            7   C8y C    25.9806  -20.0988
            8   C8x C    21.1489  -20.0988
            9   C8y C    21.1489  -21.4993
            10  C8x C    25.9806  -21.4993
            11  C1c C    27.2410  -19.3985
            12  O2a O    19.9584  -22.1995
            13  C6a C    28.4314  -20.0988
            14  C1a C    27.2410  -17.9980
            15  C1a C    18.6980  -21.4993
            16  O6a O    28.4314  -21.4993
            17  O6a O    29.6219  -19.3985 #-
            18  Z   Na   31.5125  -19.3985 #+
BOND        18
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     5   9 2
            9     6  10 2
            10    7  11 1
            11    9  12 1
            12   11  13 1
            13   11  14 1 #Down
            14   12  15 1
            15   13  16 2
            16   13  17 1
            17    7  10 1
            18    8   9 1

» Japanese version   » Back

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