KEGG   DRUG: NorethindroneHelp
Entry
D00182                      Drug                                   

Name
Norethindrone (USP);
Norethisterone (JP17);
Camila (TN);
Micronor (TN);
Primolut-N (TN)
Product
  Generic
NORLYDA (A-S Medication Solutions), LYZA (Afaxys Pharma LLC), TULANA (Afaxys Pharma), NORLYDA (Amneal Pharmaceuticals LLC), INCASSIA (Aurobindo Pharma Limited), NORETHINDRONE (Central Texas Community Health Centers), NORETHINDRONE (Glenmark Pharmaceuticals), HEATHER (Glenmark Pharmaceuticals), JENCYCLA (LUPIN LIMITED), NORETHINDRONE (LUPIN LIMITED), JENCYCLA (Lupin Pharmaceuticals), NORETHINDRONE (Lupin Pharmaceuticals), ERRIN (Mayne Pharma), CAMILA (Mayne Pharma), CAMILA (Mayne Pharma), ERRIN (Mayne Pharma), NORETHINDRONE (Mylan Pharmaceuticals), NORETHINDRONE (Mylan Pharmaceuticals), SHAROBEL (Northstar Rx LLC), NORETHINDRONE (Northstar Rx LLC), DEBLITANE (Northstar Rx LLC), NORETHINDRONE (Northstar Rx LLC), NORLYROC (Ohm Laboratories), NORETHINDRONE (Proficient Rx LP), LYZA (RPK Pharmaceuticals), ERRIN (Teva Pharmaceuticals USA), NORA BE (Watson Pharma)
Formula
C20H26O2
Exact mass
298.1933
Mol weight
298.4192
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01666  Progesterone receptor agonist
 DG02004  Progesterone
Enzyme inducer
 DG02885  CYP2C19 inducer
Remark
Same as: C05028
Therapeutic category: 2479
ATC code: G03AC01 G03DC02
Chemical structure group: DG00456
Product (DG00456): D00182<JP/US> D00953<US>
Product (mixture): D09188<JP/US> D04483<JP/US> D04462<JP/US>
Efficacy
Contraceptive, Progesterone receptor agonist
Comment
Progestin, Estren derivative
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
Interaction
Drug interaction
Structure map
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AC Progestogens
     G03AC01 Norethisterone
      D00182  Norethindrone (USP) <JP/US>
   G03D PROGESTOGENS
    G03DC Estren derivatives
     G03DC02 Norethisterone
      D00182  Norethindrone (USP) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Norethindrone
    D00182  Norethindrone (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   247  Estrogen and progesterone preparations
    2479  Others
     D00182  Norethindrone (USP); Norethisterone (JP17)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D00182  Norethindrone (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00182  Norethisterone
Drug classes of therapeutic agents [br08360.html]
 Endocrine and hormonal agents
  D00182
BRITE hierarchy
Other DBs
CAS: 68-22-4
PubChem: 7847250
ChEBI: 7627
ChEMBL: CHEMBL1162 CHEMBL2136460 CHEMBL266115
DrugBank: DB00717
PDB-CCD: NDR[PDBj]
LigandBox: D00182
NIKKAJI: J1.416H
LinkDB All DBs
KCF data Show

ATOM        22
            1   C1y C    26.8452  -17.3412
            2   C1z C    26.8512  -15.9656
            3   C1y C    25.6547  -18.0321
            4   C1x C    29.2262  -17.3473
            5   C1z C    28.0417  -15.2747
            6   C1x C    25.6484  -15.2810
            7   C1a C    26.8019  -14.4420
            8   C1y C    24.4702  -17.3536
            9   C1x C    25.5970  -19.4015
            10  C1x C    29.2324  -15.9718
            11  C3b C    29.1954  -14.5962
            12  O1a O    28.0357  -13.5161
            13  C1x C    24.5279  -15.9779
            14  C1y C    23.2921  -18.0384
            15  C1x C    24.4826  -20.0800
            16  C3a C    30.3488  -13.9116
            17  C2y C    23.2921  -19.3954
            18  C1x C    22.1200  -17.3720
            19  C2x C    22.1200  -20.0800
            20  C1x C    20.9542  -18.0384
            21  C5x C    20.9542  -19.3954
            22  O5x O    19.7884  -20.0616
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     2   7 1 #Up
            7     3   8 1
            8     3   9 1
            9     4  10 1
            10    5  11 1 #Down
            11    5  12 1 #Up
            12    6  13 1
            13    8  14 1
            14    9  15 1
            15   11  16 3
            16   14  17 1
            17   14  18 1
            18   17  19 2
            19   18  20 1
            20   19  21 1
            21   21  22 2
            22    5  10 1
            23    8  13 1
            24   15  17 1
            25   20  21 1

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