KEGG   DRUG: Norethindrone
Entry
D00182                      Drug                                   
Name
Norethindrone (USP);
Norethisterone (JP18);
Camila (TN);
Micronor (TN);
Primolut-N (TN)
Product
  Generic
Formula
C20H26O2
Exact mass
298.1933
Mol weight
298.42
Structure
Simcomp
Class
Hormonal agent
 DG02004  Progesterone
 DG01666  Progesterone receptor agonist
Remark
Same as: C05028
Therapeutic category: 2479
ATC code: G03AC01 G03DC02
Chemical structure group: DG00456
Product (DG00456): D00182<JP/US> D00953<US>
Product (mixture): D04483<JP/US> D09188<JP/US>
Efficacy
Contraceptive, Progesterone receptor agonist
Comment
Progestin, Estren derivative
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
Interaction
Structure map
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AC Progestogens
     G03AC01 Norethisterone
      D00182  Norethindrone (USP) <JP/US>
   G03D PROGESTOGENS
    G03DC Estren derivatives
     G03DC02 Norethisterone
      D00182  Norethindrone (USP) <JP/US>
USP drug classification [BR:br08302]
 Contraceptives
  Oral Progestins
   Norethindrone
    D00182  Norethindrone (USP)
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Norethindrone
    D00182  Norethindrone (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   247  Estrogen and progesterone preparations
    2479  Others
     D00182  Norethindrone (USP); Norethisterone (JP18)
Drug groups [BR:br08330]
 Hormonal agent
  DG02004  Progesterone
   DG00456  Norethisterone
    D00182  Norethindrone
  DG01666  Progesterone receptor agonist
   DG00456  Norethisterone
    D00182  Norethindrone
Drug classes [BR:br08332]
 Endocrine and hormonal agent
  DG02004  Progesterone
   D00182  Norethindrone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D00182  Norethindrone (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00182  Norethisterone
Drug groups [BR:br08330]
 Hormonal agent
  DG02004  Progesterone
   DG00456  Norethisterone
  DG01666  Progesterone receptor agonist
   DG00456  Norethisterone
Other DBs
CAS: 68-22-4
PubChem: 7847250
ChEBI: 7627
PDB-CCD: NDR[PDBj]
LigandBox: D00182
NIKKAJI: J1.416H
LinkDB
KCF data

ATOM        22
            1   C1y C    26.8452  -17.3412
            2   C1z C    26.8512  -15.9656
            3   C1y C    25.6547  -18.0321
            4   C1x C    29.2262  -17.3473
            5   C1z C    28.0417  -15.2747
            6   C1x C    25.6484  -15.2810
            7   C1a C    26.8019  -14.4420
            8   C1y C    24.4702  -17.3536
            9   C1x C    25.5970  -19.4015
            10  C1x C    29.2324  -15.9718
            11  C3b C    29.1954  -14.5962
            12  O1a O    28.0357  -13.5161
            13  C1x C    24.5279  -15.9779
            14  C1y C    23.2921  -18.0384
            15  C1x C    24.4826  -20.0800
            16  C3a C    30.3488  -13.9116
            17  C2y C    23.2921  -19.3954
            18  C1x C    22.1200  -17.3720
            19  C2x C    22.1200  -20.0800
            20  C1x C    20.9542  -18.0384
            21  C5x C    20.9542  -19.3954
            22  O5x O    19.7884  -20.0616
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     2   7 1 #Up
            7     3   8 1
            8     3   9 1
            9     4  10 1
            10    5  11 1 #Down
            11    5  12 1 #Up
            12    6  13 1
            13    8  14 1
            14    9  15 1
            15   11  16 3
            16   14  17 1
            17   14  18 1
            18   17  19 2
            19   18  20 1
            20   19  21 1
            21   21  22 2
            22    5  10 1
            23    8  13 1
            24   15  17 1
            25   20  21 1

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