KEGG   DRUG: AllopurinolHelp
Entry
D00224                      Drug                                   

Name
Allopurinol (JP17/USP/INN);
Zyloprim (TN)
Product
ALLOPURINOL (Actavis Pharma), ALLOPURINOL (Aidarex Pharmaceuticals LLC), ALLOPURINOL (Aidarex Pharmaceuticals LLC), ALLOPURINOL (American Health Packaging), ALLOPURINOL (Bryant Ranch Prepack), ALLOPURINOL (Bryant Ranch Prepack), ALLOPURINOL (Bryant Ranch Prepack), ALLOPURINOL (Cardinal Health), ZYLOPRIM (Casper Pharma LLC), ALLOPURINOL (H. J. Harkins Company), ALLOPURINOL (Lake Erie Medical DBA Quality Care Products LLC), ALOPRIM (Mylan Institutional LLC), ALLOPURINOL (NuCare Pharmaceuticals), ALLOPURINOL (PD-Rx Pharmaceuticals), ALLOPURINOL (PD-Rx Pharmaceuticals), ALLOPURINOL (Preferred Pharmaceuticals), ALLOPURINOL (Proficient Rx LP), ZYLOPRIM (Prometheus Laboratories), ALLOPURINOL (REMEDYREPACK), ZYLOPRIM (REMEDYREPACK), ZYLOPRIM (REMEDYREPACK), ALLOPURINOL (REMEDYREPACK), ALLOPURINOL (REMEDYREPACK), ALLOPURINOL (REMEDYREPACK), ALLOPURINOL (RedPharm Drug), ALLOPURINOL (State of Florida DOH Central Pharmacy)
  Generic
ALLOPURINOL (A-S Medication Solutions), ALLOPURINOL (Accord Healthcare), ALLOPURINOL (Aphena Pharma Solutions - Tennessee), ALLOPURINOL (Aphena Pharma Solutions - Tennessee), ALLOPURINOL (Aphena Pharma Solutions - Tennessee), ALLOPURINOL (Aphena Pharma Solutions - Tennessee), ALLOPURINOL (Aphena Pharma Solutions - Tennessee), ALLOPURINOL (AvPAK), ALLOPURINOL (Blenheim Pharmacal), ALLOPURINOL (Blenheim Pharmacal), ALLOPURINOL (Bryant Ranch Prepack), ALLOPURINOL (Bryant Ranch Prepack), ALLOPURINOL (Cadila Healthcare Limited), ALLOPURINOL (Cardinal Health), ALLOPURINOL (Clinical Solutions Wholesale), ALLOPURINOL (Contract Pharmacy Services-PA), ALLOPURINOL (Contract Pharmacy Services-PA), ZYLOPRIM (Contract Pharmacy Services-PA), ALLOPURINOL (DIRECT RX), ALLOPURINOL (Denton Pharma), ALLOPURINOL (Dr. Reddy's Laboratories Limited), ALLOPURINOL (Golden State Medical Supply), ALLOPURINOL (Ingenus Pharmaceuticals LLC), ALLOPURINOL (Lake Erie Medical DBA Quality Care Products LLC), ALLOPURINOL (Lake Erie Medical DBA Quality Care Products LLC), ALLOPURINOL (Lake Erie Medical DBA Quality Care Products LLC), ALLOPURINOL (Major Pharamceuticals), ALLOPURINOL (Major Pharmaceuticals), ALLOPURINOL (McKesson Corporation), ALLOPURINOL (Mylan Institutional), ALLOPURINOL (Mylan Pharmaceuticals), ALLOPURINOL (NCS HealthCare of KY), ALLOPURINOL (Northstar RxLLC), ALLOPURINOL (Northwind Pharmaceuticals), ALLOPURINOL (NuCare Pharmaceuticals), ALLOPURINOL (NuCare Pharmaceuticals), ALLOPURINOL (PD-Rx Pharmaceuticals), ALLOPURINOL (PD-Rx Pharmaceuticals), ALLOPURINOL (Par Pharmaceutical), ALLOPURINOL (Preferred Pharmaceuticals), ALLOPURINOL (Preferred Pharmaceuticals), ALLOPURINOL (Preferred Pharmaceuticals), ALLOPURINOL (Preferred Pharmaceuticals), ALLOPURINOL (Preferred Pharmaceuticals), ALLOPURINOL (Proficient Rx LP), ALLOPURINOL (REMEDYREPACK), ALLOPURINOL (REMEDYREPACK), ALLOPURINOL (REMEDYREPACK), ALLOPURINOL (REMEDYREPACK), ALLOPURINOL (REMEDYREPACK), ALLOPURINOL (Ranbaxy Pharmaceuticals), ALLOPURINOL (Rebel Distributors Corp.), ALLOPURINOL (RedPharm Drug), ALLOPURINOL (St Marys Medical Park Pharmacy), ALLOPURINOL (St Marys Medical Park Pharmacy), ALLOPURINOL (St. Mary's Medical Park Pharmacy), ALLOPURINOL (St. Mary's Medical Park Pharmacy), ALLOPURINOL (State of Florida DOH Central Pharmacy), ALLOPURINOL (Sun Pharmaceutical Industries), ALLOPURINOL (Unit Dose Services), ALLOPURINOL (Unit Dose Services), ALLOPURINOL (Unit Dose Services), ALLOPURINOL (Unit Dose Services), ALLOPURINOL (Zydus Pharmaceuticals (USA))
Formula
C5H4N4O
Exact mass
136.0385
Mol weight
136.1115
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01503  Xanthine dehydrogenase inhibitor
Enzyme inhibitor
 DG01634  CYP1A2 inhibitor
Remark
Therapeutic category: 3943
ATC code: M04AA01
Chemical structure group: DG00779
Product (DG00779): D00224<JP/US> D07564<US>
Efficacy
Gout suppressant, Uric acid biosynthesis inhibitor, Xanthine oxidase inhibitor
  Disease
Primary or secondary gout [DS:H01532]
Target
XDH [HSA:7498] [KO:K00106]
  Pathway
hsa00230  Purine metabolism
hsa04146  Peroxisome
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Drug interaction
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M04 ANTIGOUT PREPARATIONS
   M04A ANTIGOUT PREPARATIONS
    M04AA Preparations inhibiting uric acid production
     M04AA01 Allopurinol
      D00224  Allopurinol (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antigout Agents
  Allopurinol
   D00224  Allopurinol (JP17/USP/INN)
 Antineoplastics
  Treatment Adjuncts
   Allopurinol
    D00224  Allopurinol (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   394  Gout preparations
    3943  Allopurinols
     D00224  Allopurinol (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Xanthine dehydrogenase/oxidase
    XDH
     D00224  Allopurinol (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00224  Allopurinol
  D00224  Allopurinol tablets
Drug classes of therapeutic agents [br08360.html]
 Antirheumatic and antigout agents
  D00224
BRITE hierarchy
Other DBs
CAS: 315-30-0
PubChem: 7847291
ChEBI: 40279
ChEMBL: CHEMBL1467
DrugBank: DB00437
LigandBox: D00224
NIKKAJI: J2.034F
LinkDB All DBs
KCF data Show

ATOM        10
            1   C8y C    18.5315  -16.1687
            2   C8y C    18.5315  -17.5678
            3   C8y C    19.7490  -15.4662
            4   C8x C    17.1967  -15.7414
            5   N5x N    19.7490  -18.2703
            6   N4x N    17.2026  -18.0068
            7   N5x N    20.9548  -16.1687
            8   O1a O    19.7490  -14.0673
            9   N5x N    16.3773  -16.8711
            10  C8x C    20.9548  -17.5678
BOND        11
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     5  10 2
            10    6   9 1
            11    7  10 1

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