KEGG   DRUG: Carbamazepine
Entry
D00252                      Drug                                   
Name
Carbamazepine (JP18/USP/INN);
Equetro (TN);
Tegretol (TN)
Product
CARBATROL (Takeda Pharmaceuticals America), TEGRETOL (Novartis Pharmaceuticals Corporation)
  Generic
CARBAMAZEPINE (A-S Medication Solutions), CARBAMAZEPINE (ANI Pharmaceuticals), CARBAMAZEPINE (ATLANTIC BIOLOGICALS CORP.), CARBAMAZEPINE (Ajanta Pharma USA), CARBAMAZEPINE (American Health Packaging), CARBAMAZEPINE (American Health Packaging), CARBAMAZEPINE (American Health Packaging), CARBAMAZEPINE (Amneal Pharmaceuticals NY LLC), CARBAMAZEPINE (Aphena Pharma Solutions - Tennessee), CARBAMAZEPINE (Aphena Pharma Solutions - Tennessee), CARBAMAZEPINE (Apotex Corp.), CARBAMAZEPINE (Apotex Corp.), CARBAMAZEPINE (Atlantic Biologicals Corps), CARBAMAZEPINE (AvPAK), CARBAMAZEPINE (Bionpharma Inc.,), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Cardinal Health 107), CARBAMAZEPINE (Chartwell RX), CARBAMAZEPINE (Coupler LLC), CARBAMAZEPINE (Coupler), CARBAMAZEPINE (Epic Pharma), CARBAMAZEPINE (Eywa Pharma), CARBAMAZEPINE (Golden State Medical Supply), CARBAMAZEPINE (Golden State Medical Supply), CARBAMAZEPINE (Golden State Medical Supply), CARBAMAZEPINE (Golden State Medical Supply), CARBAMAZEPINE (Ingenus Pharmaceuticals), CARBAMAZEPINE (Jubilant Cadista Pharmaceuticals), CARBAMAZEPINE (Major Pharmaceuticals), CARBAMAZEPINE (Major Pharmaceuticals), CARBAMAZEPINE (Major Pharmaceuticals), CARBAMAZEPINE (NCS HealthCare of KY), CARBAMAZEPINE (NCS HealthCare of KY), CARBAMAZEPINE (NIVAGEN PHARMACEUTICALS), CARBAMAZEPINE (Northstar Rx LLC), CARBAMAZEPINE (Nostrum Laboratories), CARBAMAZEPINE (NuCare Pharmaceuticals), CARBAMAZEPINE (PD-Rx Pharmaceuticals), CARBAMAZEPINE (Prasco Laboratories), CARBAMAZEPINE (Preferred Pharmaceuticals), CARBAMAZEPINE (Preferred Pharmaceuticals), CARBAMAZEPINE (Proficient Rx LP), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (Rising Pharma Holdings), CARBAMAZEPINE (Sandoz), CARBAMAZEPINE (Taro Pharmaceuticals U.S.A.), CARBAMAZEPINE (Taro Pharmaceuticals U.S.A.), CARBAMAZEPINE (Teva Pharmaceuticals USA), CARBAMAZEPINE (Torrent Pharmaceuticals Limited), CARBAMAZEPINE (UMEDICA LABORATORIES PRIVATE LIMITED), CARBAMAZEPINE (Unichem Pharmaceuticals (USA)), CARBAMAZEPINE (Upsher-Smith Laboratories), CARBAMAZEPINE (VGYAAN Pharmaceuticals LLC), CARBAMAZEPINE (Zydus Lifesciences Limited), CARBAMAZEPINE (Zydus Pharmaceuticals (USA)), CARBAMAZEPINE (direct rx), CARBAMAZEPINE ER (AustarPharma LLC), CARBAMAZEPINE ER (Chartwell RX), EPITOL (Teva Pharmaceuticals USA)
Formula
C15H12N2O
Exact mass
236.0950
Mol weight
236.27
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03199  Antiepileptic agent
  DG02034  Carboxamide antiepileptic
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG02853  CYP3A/CYP3A4 inducer
  DG01635  CYP3A4 inducer
Transporter inducer
 DG01893  ABCB1 inducer
Remark
Same as: C06868
Therapeutic category: 1139 1179
ATC code: N03AF01
Product: D00252<JP/US>
Efficacy
Analgesic, Antiepileptic
  Disease
Trigeminal neuralgia [DS:H01638]
Comment
Carboxamide derivative
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Transporter induction: ABCB1 [HSA:5243]
Structure map
map07033  Anticonvulsants
map07231  Sodium channel blocking drugs
Other map
map00982  Drug metabolism - cytochrome P450
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AF Carboxamide derivatives
     N03AF01 Carbamazepine
      D00252  Carbamazepine (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Carbamazepine
    D00252  Carbamazepine (JP18/USP/INN)
 Bipolar Agents
  Mood Stabilizers
   Carbamazepine
    D00252  Carbamazepine (JP18/USP/INN)
 Central Nervous System Agents
  Central Nervous System, Other
   Carbamazepine
    D00252  Carbamazepine (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00252  Carbamazepine (JP18/USP/INN)
   117  Psychotropics
    1179  Others
     D00252  Carbamazepine (JP18/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   DG02034  Carboxamide antiepileptic
    D00252  Carbamazepine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00252  Carbamazepine
 Metabolizing enzyme inducer
  DG02853  CYP3A/CYP3A4 inducer
   DG01635  CYP3A4 inducer
    D00252  Carbamazepine
 Transporter inducer
  DG01893  ABCB1 inducer
   D00252  Carbamazepine
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D00252  Carbamazepine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN2A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN3A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN4A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN5A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN8A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN9A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN10A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN11A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00252  Carbamazepine
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00252
 Drug transporters
  D00252
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00252
Other DBs
CAS: 298-46-4
PubChem: 7847318
ChEBI: 3387
PDB-CCD: N6W[PDBj]
LigandBox: D00252
NIKKAJI: J8.590A
LinkDB
KCF data

ATOM        18
            1   C8y C    25.8138  -16.0918
            2   N1y N    27.0678  -15.4768
            3   C8y C    28.3384  -16.0677
            4   C8y C    28.6645  -17.4200
            5   C8y C    25.5184  -17.4703
            6   C2x C    27.8109  -18.5337
            7   C2x C    26.4089  -18.5521
            8   C8x C    24.7745  -15.1529
            9   C8x C    23.4416  -15.5834
            10  C8x C    23.1462  -16.9619
            11  C8x C    24.1856  -17.9009
            12  C8x C    30.0176  -17.7825
            13  C8x C    31.0080  -16.7920
            14  C8x C    30.6455  -15.4389
            15  C8x C    29.2925  -15.0764
            16  C5a C    27.1234  -14.0772
            17  O5a O    25.8856  -13.3793
            18  N1a N    28.3126  -13.3740
BOND        20
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 2
            8     1   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    5  11 2
            13    4  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15   3 2
            18    2  16 1
            19   16  17 2
            20   16  18 1

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