KEGG   DRUG: Chlorthalidone
Entry
D00272                      Drug                                   
Name
Chlorthalidone (USP);
Chlortalidone (JAN/INN);
Hygroton (TN);
Thalitone (TN)
Product
  Generic
CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (Ajanta Pharma USA), CHLORTHALIDONE (American Health Packaging), CHLORTHALIDONE (Amneal Pharmaceuticals LLC), CHLORTHALIDONE (Aphena Pharma Solutions - Tennessee), CHLORTHALIDONE (Aphena Pharma Solutions - Tennessee), CHLORTHALIDONE (Aphena Pharma Solutions - Tennessee), CHLORTHALIDONE (Ascend Laboratories), CHLORTHALIDONE (AvPAK), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Cadila Healthcare Limited), CHLORTHALIDONE (Chartwell RX), CHLORTHALIDONE (DOH CENTRAL PHARMACY), CHLORTHALIDONE (Denton Pharma), CHLORTHALIDONE (Denton Pharma), CHLORTHALIDONE (Denton Pharma), CHLORTHALIDONE (Direct_Rx), CHLORTHALIDONE (Dr. Reddy's Laboratories), CHLORTHALIDONE (JUBILANT CADISTA PHARMACEUTICALS), CHLORTHALIDONE (Lake Erie Medical DBA Quality Care Products LLC), CHLORTHALIDONE (Major Pharmaceuticals), CHLORTHALIDONE (Mylan Institutional), CHLORTHALIDONE (Mylan Pharmaceuticals), CHLORTHALIDONE (NIVAGEN PHARMACEUTICALS), CHLORTHALIDONE (Northstar Rx LLC), CHLORTHALIDONE (Northstar Rx LLC.), CHLORTHALIDONE (Northwind Pharmaceuticals), CHLORTHALIDONE (NuCare Pharmaceuticals), CHLORTHALIDONE (NuCare Pharmaceuticals), CHLORTHALIDONE (NuCare Pharmaceuticals), CHLORTHALIDONE (PD-Rx Pharmaceuticals), CHLORTHALIDONE (Proficient Rx LP), CHLORTHALIDONE (RPK Pharmaceuticals), CHLORTHALIDONE (Rising Pharmaceuticals), CHLORTHALIDONE (Sun Pharmaceutical Industries), CHLORTHALIDONE (Unichem Pharmaceuticals (USA)), CHLORTHALIDONE (VistaPharm), CHLORTHALIDONE (Zydus Pharmaceuticals (USA))
Formula
C14H11ClN2O4S
Exact mass
338.0128
Mol weight
338.7661
Structure
Class
Cardiovascular agent
 DG03231  Antihypertensive
  DG02992  Thiazide related diuretic
 DG01690  Sulfonamide diuretic
  DG02992  Thiazide related diuretic
Remark
ATC code: C03BA04
Product: D00272<US>
Product (mixture): D10589<US> D10592<US>
Efficacy
Antihypertensive, Diuretic, Na+-Cl- symport inhibitor
  Disease
Hypertension [DS:H01633]
Nephrotic syndrome [DS:H01657]
Comment
Sulfonamide derivative
Target
SLC12A3 (TSC) [HSA:6559] [KO:K14426]
SLC12A1 (NKCC2) [HSA:6557] [KO:K14425]
Interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES
    C03BA Sulfonamides, plain
     C03BA04 Chlortalidone
      D00272  Chlorthalidone (USP) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Thiazide
   Chlorthalidone
    D00272  Chlorthalidone (USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG02992  Thiazide related diuretic
    D00272  Chlorthalidone
  DG01690  Sulfonamide diuretic
   DG02992  Thiazide related diuretic
    D00272  Chlorthalidone
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D00272  Chlorthalidone
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1 (NKCC2)
     D00272  Chlorthalidone (USP) <US>
    SLC12A3 (TSC)
     D00272  Chlorthalidone (USP) <US>
Other DBs
CAS: 77-36-1
PubChem: 7847338
ChEBI: 3654
LigandBox: D00272
NIKKAJI: J1.476A
LinkDB
KCF data

ATOM        22
            1   C8x C     7.3500  -17.0800
            2   C8x C     7.3500  -18.4800
            3   C8x C     8.5624  -19.1800
            4   C8x C     9.7749  -18.4800
            5   C8y C     9.7749  -17.0800
            6   C8y C     8.5624  -16.3800
            7   C8x C    12.1997  -18.4800
            8   C8y C    12.1997  -17.0800
            9   C1z C    10.9873  -16.3800
            10  C8x C    13.4122  -19.1800
            11  C8y C    14.6246  -18.4800
            12  C8y C    14.6246  -17.0800
            13  C8x C    13.4122  -16.3800
            14  X   Cl   15.8411  -19.1823
            15  S4a S    15.8411  -16.3777
            16  N1a N    17.0535  -15.6777
            17  O3c O    15.1370  -15.1579
            18  O3c O    16.5367  -17.5827
            19  N1x N    10.4862  -15.0106
            20  C5x C     9.0239  -15.0042
            21  O1a O    12.1997  -15.6800
            22  O5x O     8.0160  -14.0147
BOND        24
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15   11  14 1
            16   12  15 1
            17   15  16 1
            18   15  17 2
            19   15  18 2
            20    9  19 1
            21   19  20 1
            22   20   6 1
            23    9  21 1
            24   20  22 2

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