KEGG   DRUG: ChlorthalidoneHelp
Entry
D00272                      Drug                                   

Name
Chlorthalidone (USP);
Chlortalidone (JAN/INN);
Hygroton (TN);
Thalitone (TN)
Product
  Generic
CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (American Health Packaging), CHLORTHALIDONE (Aphena Pharma Solutions - Tennessee), CHLORTHALIDONE (Aphena Pharma Solutions - Tennessee), CHLORTHALIDONE (Aphena Pharma Solutions - Tennessee), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Carilion Materials Management), CHLORTHALIDONE (Dr. Reddy's Laboratories), CHLORTHALIDONE (KAISER FOUNDATION HOSPITALS), CHLORTHALIDONE (Lake Erie Medical DBA Quality Care Products LLC), CHLORTHALIDONE (Lake Erie Medical DBA Quality Care Products LLC), CHLORTHALIDONE (Mylan Institutional), CHLORTHALIDONE (Mylan Pharmaceuticals), CHLORTHALIDONE (NIVAGEN PHARMACEUTICALS), CHLORTHALIDONE (Northstar Rx LLC), CHLORTHALIDONE (NuCare Pharmaceuticals), CHLORTHALIDONE (NuCare Pharmaceuticals), CHLORTHALIDONE (PD-Rx Pharmaceuticals), CHLORTHALIDONE (Preferred Pharmaceuticals), CHLORTHALIDONE (REMEDYREPACK), CHLORTHALIDONE (REMEDYREPACK), CHLORTHALIDONE (REMEDYREPACK), CHLORTHALIDONE (RPK Pharmaceuticals), CHLORTHALIDONE (Rebel Distributors Corp), CHLORTHALIDONE (Rising Pharmaceuticals), CHLORTHALIDONE (Sun Pharmaceutical Industries)
Formula
C14H11ClN2O4S
Exact mass
338.0128
Mol weight
338.7661
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
Remark
ATC code: C03BA04
Product: D00272<US>
Product (mixture): D10589<US> D10592<US>
Efficacy
Antihypertensive, Diuretic, Na+-Cl- symport inhibitor
  Disease
Hypertension [DS:H01633]
Nephrotic syndrome [DS:H01657]
Comment
Sulfonamide derivative
Target
SLC12A3 (TSC) [HSA:6559] [KO:K14426]
SLC12A1 (NKCC2) [HSA:6557] [KO:K14425]
Interaction
Drug interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES
    C03BA Sulfonamides, plain
     C03BA04 Chlortalidone
      D00272  Chlorthalidone (USP) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Thiazide
   Chlorthalidone
    D00272  Chlorthalidone (USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1 (NKCC2)
     D00272  Chlorthalidone (USP) <US>
    SLC12A3 (TSC)
     D00272  Chlorthalidone (USP) <US>
Drug classes of therapeutic agents [br08360.html]
 Cardiovascular agents
  D00272
BRITE hierarchy
Other DBs
CAS: 77-36-1
PubChem: 7847338
ChEBI: 3654
ChEMBL: CHEMBL1055
DrugBank: DB00310
LigandBox: D00272
NIKKAJI: J1.476A
LinkDB All DBs
KCF data Show

ATOM        22
            1   C8x C     7.3500  -17.0800
            2   C8x C     7.3500  -18.4800
            3   C8x C     8.5624  -19.1800
            4   C8x C     9.7749  -18.4800
            5   C8y C     9.7749  -17.0800
            6   C8y C     8.5624  -16.3800
            7   C8x C    12.1997  -18.4800
            8   C8y C    12.1997  -17.0800
            9   C1z C    10.9873  -16.3800
            10  C8x C    13.4122  -19.1800
            11  C8y C    14.6246  -18.4800
            12  C8y C    14.6246  -17.0800
            13  C8x C    13.4122  -16.3800
            14  X   Cl   15.8411  -19.1823
            15  S4a S    15.8411  -16.3777
            16  N1a N    17.0535  -15.6777
            17  O3c O    15.1370  -15.1579
            18  O3c O    16.5367  -17.5827
            19  N1x N    10.4862  -15.0106
            20  C5x C     9.0239  -15.0042
            21  O1a O    12.1997  -15.6800
            22  O5x O     8.0160  -14.0147
BOND        24
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15   11  14 1
            16   12  15 1
            17   15  16 1
            18   15  17 2
            19   15  18 2
            20    9  19 1
            21   19  20 1
            22   20   6 1
            23    9  21 1
            24   20  22 2

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