KEGG   DRUG: IsradipineHelp
Entry
D00349                      Drug                                   

Name
Isradipine (USP/INN);
Dynacirc (TN)
Product
  Generic
Formula
C19H21N3O5
Exact mass
371.1481
Mol weight
371.3871
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01928  Dihydropyridine calcium channel blocker
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Remark
ATC code: C08CA03
Product: D00349<US>
Efficacy
Antihypertensive, Calcium channel blocker
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Drug interaction
Structure map
map07036  Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA03 Isradipine
      D00349  Isradipine (USP/INN) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Calcium Channel Blocking Agents
   Isradipine
    D00349  Isradipine (USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-L
     D00349  Isradipine (USP/INN) <US>
BRITE hierarchy
Other DBs
CAS: 75695-93-1
PubChem: 7847415
ChEBI: 6073
ChEMBL: CHEMBL1648
DrugBank: DB00270
LigandBox: D00349
NIKKAJI: J33.142B
LinkDB All DBs
KCF data Show

ATOM        27
            1   C1y C     7.0000  -13.1600
            2   C2y C     8.1900  -12.4600
            3   C2y C     5.8100  -12.4600
            4   C8y C     7.0000  -15.5400
            5   C2y C     8.1900  -11.1300
            6   C7a C     9.3800  -13.1600
            7   C2y C     5.8100  -11.1300
            8   C7a C     4.6900  -13.0900
            9   C8x C     8.1900  -16.2400
            10  C8y C     5.8100  -16.2400
            11  N1x N     7.0000  -10.4300
            12  C1a C     9.3800  -10.4300
            13  O7a O    10.5000  -12.4600
            14  O6a O     9.3800  -14.4900
            15  C1a C     4.6900  -10.4300
            16  O7a O     3.5000  -12.4600
            17  O6a O     4.6900  -14.4900
            18  C8x C     8.1900  -17.5000
            19  C8y C     5.8100  -17.5000
            20  C1c C    11.6900  -13.1600
            21  C1a C     2.3100  -13.0900
            22  C8x C     7.0000  -18.2000
            23  C1a C    12.9081  -12.4699
            24  C1a C    11.6786  -14.5600
            25  N5x N     4.6117  -15.8506
            26  O2x O     3.8710  -16.8700
            27  N5x N     4.6117  -17.8894
BOND        29
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    6  14 2
            14    7  15 1
            15    8  16 1
            16    8  17 2
            17    9  18 1
            18   10  19 1
            19   13  20 1
            20   16  21 1
            21   18  22 2
            22    7  11 1
            23   19  22 1
            24   20  23 1
            25   20  24 1
            26   10  25 2
            27   25  26 1
            28   26  27 1
            29   19  27 2

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