| Entry |
|
|---|
| Name |
Isradipine (USP/INN);
Dynacirc (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C19H21N3O5
|
|---|
| Exact mass |
371.1481
|
|---|
| Mol weight |
371.39
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
|
|---|
| Remark |
|
|---|
| Efficacy |
Antihypertensive, Calcium channel blocker |
|---|
| Disease |
|
|---|
| Comment |
Dihydropyridine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA03 Isradipine
D00349 Isradipine (USP/INN) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Calcium Channel Blocking Agents, Dihydropyridines
Isradipine
D00349 Isradipine (USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
D00349 Isradipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
D00349 Isradipine
Drug classes [BR:br08332]
Cardiovascular agent
DG01928 Dihydropyridine calcium channel blocker
D00349 Isradipine
DG03231 Antihypertensive
D00349 Isradipine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D00349 Isradipine (USP/INN) <US>
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 27
1 C1y C 7.0000 -13.1600
2 C2y C 8.1900 -12.4600
3 C2y C 5.8100 -12.4600
4 C8y C 7.0000 -15.5400
5 C2y C 8.1900 -11.1300
6 C7a C 9.3800 -13.1600
7 C2y C 5.8100 -11.1300
8 C7a C 4.6900 -13.0900
9 C8x C 8.1900 -16.2400
10 C8y C 5.8100 -16.2400
11 N1x N 7.0000 -10.4300
12 C1a C 9.3800 -10.4300
13 O7a O 10.5000 -12.4600
14 O6a O 9.3800 -14.4900
15 C1a C 4.6900 -10.4300
16 O7a O 3.5000 -12.4600
17 O6a O 4.6900 -14.4900
18 C8x C 8.1900 -17.5000
19 C8y C 5.8100 -17.5000
20 C1c C 11.6900 -13.1600
21 C1a C 2.3100 -13.0900
22 C8x C 7.0000 -18.2000
23 C1a C 12.9081 -12.4699
24 C1a C 11.6786 -14.5600
25 N5x N 4.6117 -15.8506
26 O2x O 3.8710 -16.8700
27 N5x N 4.6117 -17.8894
BOND 29
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 2
9 4 10 1
10 5 11 1
11 5 12 1
12 6 13 1
13 6 14 2
14 7 15 1
15 8 16 1
16 8 17 2
17 9 18 1
18 10 19 1
19 13 20 1
20 16 21 1
21 18 22 2
22 7 11 1
23 19 22 1
24 20 23 1
25 20 24 1
26 10 25 2
27 25 26 1
28 26 27 1
29 19 27 2
|
|---|
