Microvascular complications of diabetes [DS:H02559]
Description
Diabetic nephropathy (DN), also called diabetic kidney disease, is a microvascular complication of diabetes that induces dysfunction in various cell types of the kidney, ultimately leading to renal failure. A clinical syndrome of DN is characterized by decreased glomerular filtration rate (GFR), excessive deposition of extracellular matrix proteins, thickening of the peripheral glomerular basement membrane, glomerular hypertrophy, tubulointerstitial fibrosis, increased excretion of albumin, and decreased creatinine clearance. It has been reported that angiotensin-converting enzyme, vascular endothelial growth factor A, and superoxide dismutase 2 are associated with DN.
Category
Metabolic disease; Endocrine disease; Urinary system disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
16 Diseases of the genitourinary system
Diseases of the urinary system
Kidney failure
GB61 Chronic kidney disease
H01456 Diabetic nephropathy
Marre M, Jeunemaitre X, Gallois Y, Rodier M, Chatellier G, Sert C, Dusselier L, Kahal Z, Chaillous L, Halimi S, Muller A, Sackmann H, Bauduceau B, Bled F, Passa P, Alhenc-Gelas F
Title
Contribution of genetic polymorphism in the renin-angiotensin system to the development of renal complications in insulin-dependent diabetes: Genetique de la Nephropathie Diabetique (GENEDIAB) study group.
