KEGG   DISEASE: Diabetic nephropathy
Entry
H01456                      Disease                                
Name
Diabetic nephropathy
  Supergrp
Microvascular complications of diabetes [DS:H02559]
Description
Diabetic nephropathy (DN), also called diabetic kidney disease, is a microvascular complication of diabetes that induces dysfunction in various cell types of the kidney, ultimately leading to renal failure. A clinical syndrome of DN is characterized by decreased glomerular filtration rate (GFR), excessive deposition of extracellular matrix proteins, thickening of the peripheral glomerular basement membrane, glomerular hypertrophy, tubulointerstitial fibrosis, increased excretion of albumin, and decreased creatinine clearance. It has been reported that angiotensin-converting enzyme, vascular endothelial growth factor A, and superoxide dismutase 2 are associated with DN.
Category
Metabolic disease; Endocrine disease; Urinary system disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 16 Diseases of the genitourinary system
  Diseases of the urinary system
   Kidney failure
    GB61  Chronic kidney disease
     H01456  Diabetic nephropathy
Pathway
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04614  Renin-angiotensin system
hsa04068  FoxO signaling pathway
hsa04211  Longevity regulating pathway
Gene
(Type 1 DN) VEGFA [HSA:7422] [KO:K05448]
(Type 1,2 DN) ACE [HSA:1636] [KO:K01283]
(Type 1,2 DN) SOD2 [HSA:6648] [KO:K04564]
Drug
Finerenone [DR:D10633]
Captopril [DR:D00251]
Losartan potassium [DR:D00357]
Irbesartan [DR:D00523]
Other DBs
ICD-11: GB61.Z
ICD-10: E14.2
MeSH: D003928
OMIM: 603933 612624 612634
Reference
  Authors
Alkayyali S, Lyssenko V
  Title
Genetics of diabetes complications.
  Journal
Mamm Genome 25:384-400 (2014)
DOI:10.1007/s00335-014-9543-x
Reference
  Authors
Mooyaart AL, Valk EJ, van Es LA, Bruijn JA, de Heer E, Freedman BI, Dekkers OM, Baelde HJ
  Title
Genetic associations in diabetic nephropathy: a meta-analysis.
  Journal
Diabetologia 54:544-53 (2011)
DOI:10.1007/s00125-010-1996-1
Reference
  Authors
Rizvi S, Raza ST, Mahdi F
  Title
Association of genetic variants with diabetic nephropathy.
  Journal
World J Diabetes 5:809-16 (2014)
DOI:10.4239/wjd.v5.i6.809
Reference
  Authors
Lim AKh
  Title
Diabetic nephropathy - complications and treatment.
  Journal
Int J Nephrol Renovasc Dis 7:361-81 (2014)
DOI:10.2147/IJNRD.S40172
Reference
PMID:9120002 (ACE)
  Authors
Marre M, Jeunemaitre X, Gallois Y, Rodier M, Chatellier G, Sert C, Dusselier L, Kahal Z, Chaillous L, Halimi S, Muller A, Sackmann H, Bauduceau B, Bled F, Passa P, Alhenc-Gelas F
  Title
Contribution of genetic polymorphism in the renin-angiotensin system to the development of renal complications in insulin-dependent diabetes: Genetique de la Nephropathie Diabetique (GENEDIAB) study group.
  Journal
J Clin Invest 99:1585-95 (1997)
DOI:10.1172/JCI119321
Reference
PMID:17192491 (SOD2)
  Authors
Mollsten A, Marklund SL, Wessman M, Svensson M, Forsblom C, Parkkonen M, Brismar K, Groop PH, Dahlquist G
  Title
A functional polymorphism in the manganese superoxide dismutase gene and diabetic nephropathy.
  Journal
Diabetes 56:265-9 (2007)
DOI:10.2337/db06-0698
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