KEGG   DRUG: TrandolaprilHelp
Entry
D00383                      Drug                                   

Name
Trandolapril (JAN/INN);
Mavik (TN)
Product
  Generic
Formula
C24H34N2O5
Exact mass
430.2468
Mol weight
430.5372
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01501  Angiotensin-converting enzyme inhibitor
 DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
Remark
Therapeutic category: 2144
ATC code: C09AA10
Product: D00383<JP/US>
Product (mixture): D10282<US>
Efficacy
Antihypertensive, Angiotensin-converting enzyme inhibitor
  Disease
Hypertension [DS:H01633]
Comment
Active form of prodrug: Trandolaprilat [CPD:C21515]
Target
ACE (CD143) [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA10 Trandolapril
      D00383  Trandolapril (JAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Trandolapril
    D00383  Trandolapril (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2144  Angiotensin converting enzyme inhibitors
     D00383  Trandolapril (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D00383  Trandolapril (JAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Cardiovascular agents
  D00383
Prodrugs [br08324.html]
 D00383
BRITE hierarchy
Other DBs
CAS: 87679-37-6
PubChem: 7847449
ChEBI: 9649
ChEMBL: CHEMBL1519 CHEMBL2079671
DrugBank: DB00519
LigandBox: D00383
NIKKAJI: J33.158I
LinkDB All DBs
KCF data Show

ATOM        31
            1   N1y N    28.3850  -18.5792
            2   C1y C    29.6683  -19.1392
            3   C1y C    28.5425  -17.1850
            4   C5a C    27.1775  -19.2850
            5   C1y C    30.6075  -18.1008
            6   C1x C    30.1000  -20.4692
            7   C1x C    29.9134  -16.8933
            8   C6a C    28.5308  -15.7792
            9   C1c C    25.9642  -18.5850
            10  O5a O    27.1834  -20.6850
            11  C1x C    31.9784  -18.3984
            12  C1x C    31.4709  -20.7667
            13  O6a O    29.7326  -15.0675
            14  O6a O    27.3116  -15.0908
            15  N1b N    24.7508  -19.2850
            16  C1a C    25.9699  -17.1850
            17  C1x C    32.4042  -19.7284
            18  C1c C    23.5432  -18.5909
            19  C1b C    22.3300  -19.2967
            20  C7a C    23.5375  -17.1909
            21  C1b C    21.1167  -18.6083
            22  O7a O    24.7508  -16.4909
            23  O6a O    22.3183  -16.4966
            24  C8y C    19.9092  -19.2967
            25  C1b C    24.7450  -15.0908
            26  C8x C    19.9092  -20.7084
            27  C8x C    18.7074  -18.6083
            28  C1a C    23.5317  -14.3966
            29  C8x C    18.7074  -21.4141
            30  C8x C    17.4883  -19.2967
            31  C8x C    17.4883  -20.7084
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1 #Down
            8     4   9 1
            9     4  10 2
            10    5  11 1
            11    6  12 1
            12    8  13 1
            13    8  14 2
            14    9  15 1
            15    9  16 1 #Up
            16   11  17 1
            17   15  18 1
            18   18  19 1
            19   18  20 1 #Up
            20   19  21 1
            21   20  22 1
            22   20  23 2
            23   21  24 1
            24   22  25 1
            25   24  26 1
            26   24  27 2
            27   25  28 1
            28   26  29 2
            29   27  30 1
            30   29  31 1
            31    5   7 1
            32   12  17 1
            33   30  31 2

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