KEGG   DRUG: MinoxidilHelp
Entry
D00418                      Drug                                   

Name
Minoxidil (JAN/USP/INN);
Loniten (TN);
Riup (TN);
Rogaine (TN)
Product
  Generic
Formula
C9H15N5O
Exact mass
209.1277
Mol weight
209.2483
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01583  ATP-sensitive potassium channel opener
Remark
ATC code: C02DC01 D11AX01
Product: D00418<US>
Efficacy
Antihypertensive, Hair growth stimulant (topical), ATP-sensitive potassium channel opener
  Disease
Hypertension [DS:H01633]
Comment
Pyrimidine derivative
Target
ABCC8(SUR1)/KCNJ11(KIR6.2) [HSA:6833 3767] [KO:K05032 K05004]
  Pathway
hsa02010  ABC transporters
Interaction
Drug interaction
Structure map
map07232  Potassium channel blocking and opening drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02D ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
    C02DC Pyrimidine derivatives
     C02DC01 Minoxidil
      D00418  Minoxidil (JAN/USP/INN) <US>
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX01 Minoxidil
      D00418  Minoxidil (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Vasodilators, Direct-acting Arterial
   Minoxidil
    D00418  Minoxidil (JAN/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  60 Hair remedies (incl. hair growth, hair tonic, anti-dandruff, and antipruritic)
   D00418  Minoxidil (JAN/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Minoxidil
    D00418  Minoxidil (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC subfamily
    ABCC8(SUR1)/KCNJ11(KIR6.2)
     D00418  Minoxidil (JAN/USP/INN) <US>
Rx-to-OTC switch list in the USA [br08315.html]
 D00418
Rx-to-OTC switch list in Japan [br08314.html]
 D00418
BRITE hierarchy
Other DBs
CAS: 38304-91-5
PubChem: 7847484
ChEBI: 6942
ChEMBL: CHEMBL802
DrugBank: DB00350
PDB-CCD: MXD[PDBj]
LigandBox: D00418
NIKKAJI: J19.522G
LinkDB All DBs
KCF data Show

ATOM        15
            1   C8y C    25.4688  -16.6714
            2   N1y N    26.6393  -15.9984
            3   C8x C    25.4688  -18.0236
            4   N5x N    24.3041  -15.9984
            5   C1x C    27.8100  -16.6774
            6   C1x C    26.6393  -14.6522
            7   C8y C    24.3041  -18.7025
            8   C8y C    23.1275  -16.6714
            9   C1x C    28.9805  -16.0042
            10  C1x C    27.8100  -13.9733
            11  N5y N    23.1275  -18.0236 #+
            12  N1a N    24.3041  -20.0604
            13  N1a N    21.9570  -15.9984
            14  C1x C    28.9805  -14.6522
            15  O3a O    21.1726  -18.8488 #-
BOND        16
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     6  10 1
            10    7  11 1
            11    7  12 1
            12    8  13 1
            13    9  14 1
            14   11  15 1
            15    8  11 2
            16   10  14 1

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