| Entry |
|
|---|
| Name |
Quazepam (JAN/USP/INN);
Doral (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C17H11ClF4N2S
|
|---|
| Exact mass |
386.0268
|
|---|
| Mol weight |
386.79
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
DG03202 Hypnotic
DG01567 GABA-A receptor agonist
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 1124 |
|
|---|
| Efficacy |
Sedative-hypnotic |
|---|
| Disease |
|
|---|
| Comment |
Benzodiazepine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07230 | GABA-A receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05C HYPNOTICS AND SEDATIVES
N05CD Benzodiazepine derivatives
N05CD10 Quazepam
D00457 Quazepam (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Sleep Disorder Agents
Sleep Promoting Agents
GABA Receptor Complexes
Quazepam
D00457 Quazepam (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
112 Hypnotics and sedatives, anxiolytics
1124 Benzodiazepins
D00457 Quazepam (JAN/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
D00457 Quazepam
DG03202 Hypnotic
D00457 Quazepam
DG01567 GABA-A receptor agonist
D00457 Quazepam
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
D00457 Quazepam
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00457 Quazepam
Drug classes [BR:br08332]
Neuropsychiatric agent
DG03202 Hypnotic
D00457 Quazepam
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D00457 Quazepam (JAN/USP/INN) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00457
Narcotics and psychotropics in Japan [br08308.html]
Psychotropics by Cabinet order Article 3 (78 substances)
D00457
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 25
1 C2y C 14.2831 -12.8278
2 C8y C 13.4404 -11.7174
3 C8y C 13.7759 -10.3597
4 N1y N 15.0377 -9.7811
5 N2x N 15.6899 -12.7830
6 C2y C 16.2922 -10.4039
7 C1x C 16.5789 -11.7736
8 C8x C 12.7680 -9.3906
9 C8x C 11.4251 -9.7789
10 C8y C 11.0897 -11.1367
11 C8x C 12.0975 -12.1055
12 S0 S 17.3371 -9.4688
13 X Cl 9.7239 -11.5314
14 C8y C 13.6482 -14.0784
15 C8x C 12.2456 -14.0784
16 C8x C 11.5451 -15.2917
17 C8x C 12.2456 -16.5050
18 C8x C 13.6482 -16.5050
19 C8y C 14.3487 -15.2917
20 X F 15.7606 -15.2918
21 C1b C 15.0595 -8.0553
22 C1d C 16.2778 -7.3773
23 X F 17.4902 -6.6773
24 X F 16.9643 -8.5877
25 X F 15.5836 -6.1532
BOND 27
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 6 12 2
14 10 13 1
15 1 14 1
16 14 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 18 19 1
21 14 19 2
22 19 20 1
23 4 21 1
24 21 22 1
25 22 23 1
26 22 24 1
27 22 25 1
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