KEGG   DRUG: OxcarbazepineHelp
Entry
D00533                      Drug                                   

Name
Oxcarbazepine (JAN/USAN/INN);
Oxtellar (TN);
Trileptal (TN)
Product
  Generic
OXCARBAZEPINE (Aidarex Pharmaceuticals LLC), OXCARBAZEPINE (American Health Packaging), OXCARBAZEPINE (Amneal Pharmaceuticals LLC), OXCARBAZEPINE (Breckenridge Pharmaceutical), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Cardinal Health), TRILEPTAL (DIRECT RX), OXCARBAZEPINE (Glenmark Pharmaceuticals), OXCARBAZEPINE (Golden State Medical Supply), OXCARBAZEPINE (Lake Erie Medical DBA Quality Care Products LLC), OXCARBAZEPINE (Medsource Pharmaceuticals), OXCARBAZEPINE (NCS HealthCare of KY), OXCARBAZEPINE (NCS HealthCare of KY), OXCARBAZEPINE (Precision Dose), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (Ranbaxy Pharmaceuticals), OXCARBAZEPINE (Rebel Distributors Corp), OXCARBAZEPINE (Sandoz), OXCARBAZEPINE (Sun Pharmaceutical Industries Limited), OXCARBAZEPINE (TYA Pharmaceuticals), OXCARBAZEPINE (TYA Pharmaceuticals), OXCARBAZEPINE (Taro Pharmaceuticals U.S.A.), OXCARBAZEPINE (West-Ward Pharmaceticals Corp.), OXCARBAZEPINE (West-Ward Pharmaceuticals Corp.)
Formula
C15H12N2O2
Exact mass
252.0899
Mol weight
252.268
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02034  Carboxamide antiepileptics
Enzyme inhibitor
 DG01933  CYP2C19 inhibitor
Enzyme inducer
 DG02853  CYP3A inducer
 DG01897  CYP3A5 inducer
Remark
Same as: C07492
ATC code: N03AF02
Product: D00533<US>
Efficacy
Anticonvulsant, Antiepileptic
Comment
Carboxamide derivative
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
CYP inhibition: CYP2C19 [HSA:1557]
CYP induction: CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
map07033  Anticonvulsants
Other map
map00982  Drug metabolism - cytochrome P450
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AF Carboxamide derivatives
     N03AF02 Oxcarbazepine
      D00533  Oxcarbazepine (JAN/USAN/INN) <US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Oxcarbazepine
    D00533  Oxcarbazepine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00533  Oxcarbazepine (JAN/USAN/INN) <US>
    SCN2A
     D00533  Oxcarbazepine (JAN/USAN/INN) <US>
    SCN3A
     D00533  Oxcarbazepine (JAN/USAN/INN) <US>
    SCN4A
     D00533  Oxcarbazepine (JAN/USAN/INN) <US>
    SCN5A
     D00533  Oxcarbazepine (JAN/USAN/INN) <US>
    SCN8A
     D00533  Oxcarbazepine (JAN/USAN/INN) <US>
    SCN9A
     D00533  Oxcarbazepine (JAN/USAN/INN) <US>
    SCN10A
     D00533  Oxcarbazepine (JAN/USAN/INN) <US>
    SCN11A
     D00533  Oxcarbazepine (JAN/USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D00533
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00533
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00533
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and germline mutations
  D00533
BRITE hierarchy
Other DBs
CAS: 28721-07-5
PubChem: 7847599
ChEBI: 7824
ChEMBL: CHEMBL1068
DrugBank: DB00776
LigandBox: D00533
NIKKAJI: J21.258J
LinkDB All DBs
KCF data Show

ATOM        19
            1   C5x C    18.8052  -13.4873
            2   C8y C    17.9608  -12.3747
            3   C8y C    18.2969  -11.0142
            4   N1y N    19.5614  -10.4345
            5   C1x C    20.2148  -13.5126
            6   C8y C    20.8183  -11.0585
            7   C8y C    21.1056  -12.4310
            8   C8x C    17.2870  -10.0431
            9   C8x C    15.9414  -10.4323
            10  C8x C    15.6053  -11.7928
            11  C8x C    16.6151  -12.7636
            12  C8x C    22.4404  -12.8693
            13  C8x C    23.4875  -11.9323
            14  C8x C    23.2004  -10.5598
            15  C8x C    21.8653  -10.1215
            16  C5a C    19.5131   -9.0558
            17  N1a N    20.7404   -8.3728
            18  O5x O    18.0836  -14.6869
            19  O5a O    18.2961   -8.3686
BOND        21
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 1
            19   16  17 1
            20    1  18 2
            21   16  19 2

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