KEGG   DRUG: Oxcarbazepine
Entry
D00533                      Drug                                   
Name
Oxcarbazepine (JAN/USP/INN);
Oxtellar (TN);
Trileptal (TN)
Product
OXTELLAR XR (Supernus Pharmaceuticals), TRILEPTAL (Novartis Pharmaceuticals Corporation)
  Generic
OXCARBAZEPINE (Advagen Pharma Limited), OXCARBAZEPINE (Advagen Pharma), OXCARBAZEPINE (Ajanta Pharma USA), OXCARBAZEPINE (Ajanta Pharma USA), OXCARBAZEPINE (American Health Packaging), OXCARBAZEPINE (American Health Packaging), OXCARBAZEPINE (Amneal Pharmaceuticals LLC), OXCARBAZEPINE (AvPAK), OXCARBAZEPINE (AvPAK), OXCARBAZEPINE (Biocon Pharma), OXCARBAZEPINE (Bionpharma), OXCARBAZEPINE (Breckenridge Pharmaceutical), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Camber Pharmaceuticals), OXCARBAZEPINE (Camber Pharmaceuticals), OXCARBAZEPINE (Cardinal Health 107), OXCARBAZEPINE (Cardinal Health 107), OXCARBAZEPINE (Cardinal Health 107), OXCARBAZEPINE (Chartwell RX), OXCARBAZEPINE (DirectRx), OXCARBAZEPINE (EPIC PHARMA), OXCARBAZEPINE (Glenmark Pharmaceuticals), OXCARBAZEPINE (Golden State Medical Supply), OXCARBAZEPINE (Hikma Pharmaceuticals USA), OXCARBAZEPINE (Kesin Pharma), OXCARBAZEPINE (Major Pharmaceuticals), OXCARBAZEPINE (Medley Pharmaceuticals Limited), OXCARBAZEPINE (NCS HealthCare of KY), OXCARBAZEPINE (NorthStar RxLLC), OXCARBAZEPINE (NuCare Pharmaceuticals), OXCARBAZEPINE (Precision Dose), OXCARBAZEPINE (Preferred Pharmaceuticals), OXCARBAZEPINE (Proficient Rx LP), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (Sandoz), OXCARBAZEPINE (Sun Pharmaceutical Industries), OXCARBAZEPINE (Taro Pharmaceuticals U.S.A.), OXCARBAZEPINE (XLCare Pharmaceuticals)
Formula
C15H12N2O2
Exact mass
252.0899
Mol weight
252.27
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03199  Antiepileptic agent
  DG02034  Carboxamide antiepileptic
Metabolizing enzyme inhibitor
 DG01933  CYP2C19 inhibitor
Metabolizing enzyme inducer
 DG02853  CYP3A/CYP3A4 inducer
Remark
Same as: C07492
ATC code: N03AF02
Product: D00533<US>
Efficacy
Anticonvulsant, Antiepileptic
Comment
Carboxamide derivative
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
CYP induction: CYP3A [HSA:1576 1577 1551]
CYP inhibition: CYP2C19 [HSA:1557]
Structure map
map07033  Anticonvulsants
Other map
map00982  Drug metabolism - cytochrome P450
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AF Carboxamide derivatives
     N03AF02 Oxcarbazepine
      D00533  Oxcarbazepine (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Oxcarbazepine
    D00533  Oxcarbazepine (JAN/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   DG02034  Carboxamide antiepileptic
    D00533  Oxcarbazepine
 Metabolizing enzyme inhibitor
  DG01933  CYP2C19 inhibitor
   D00533  Oxcarbazepine
 Metabolizing enzyme inducer
  DG02853  CYP3A/CYP3A4 inducer
   D00533  Oxcarbazepine
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D00533  Oxcarbazepine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00533  Oxcarbazepine (JAN/USP/INN) <US>
    SCN2A
     D00533  Oxcarbazepine (JAN/USP/INN) <US>
    SCN3A
     D00533  Oxcarbazepine (JAN/USP/INN) <US>
    SCN4A
     D00533  Oxcarbazepine (JAN/USP/INN) <US>
    SCN5A
     D00533  Oxcarbazepine (JAN/USP/INN) <US>
    SCN8A
     D00533  Oxcarbazepine (JAN/USP/INN) <US>
    SCN9A
     D00533  Oxcarbazepine (JAN/USP/INN) <US>
    SCN10A
     D00533  Oxcarbazepine (JAN/USP/INN) <US>
    SCN11A
     D00533  Oxcarbazepine (JAN/USP/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D00533
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00533
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00533
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00533
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00533
Other DBs
CAS: 28721-07-5
PubChem: 7847599
ChEBI: 7824
LigandBox: D00533
NIKKAJI: J21.258J
LinkDB
KCF data

ATOM        19
            1   C5x C    18.8052  -13.4873
            2   C8y C    17.9608  -12.3747
            3   C8y C    18.2969  -11.0142
            4   N1y N    19.5614  -10.4345
            5   C1x C    20.2148  -13.5126
            6   C8y C    20.8183  -11.0585
            7   C8y C    21.1056  -12.4310
            8   C8x C    17.2870  -10.0431
            9   C8x C    15.9414  -10.4323
            10  C8x C    15.6053  -11.7928
            11  C8x C    16.6151  -12.7636
            12  C8x C    22.4404  -12.8693
            13  C8x C    23.4875  -11.9323
            14  C8x C    23.2004  -10.5598
            15  C8x C    21.8653  -10.1215
            16  C5a C    19.5131   -9.0558
            17  N1a N    20.7404   -8.3728
            18  O5x O    18.0836  -14.6869
            19  O5a O    18.2961   -8.3686
BOND        21
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 1
            19   16  17 1
            20    1  18 2
            21   16  19 2

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