KEGG   DRUG: BenzocaineHelp
Entry
D00552                      Drug                                   

Name
Benzocaine (USP/INN);
Ethyl aminobenzoate (JP17);
Parathesin (TN)
Product
  Other
Formula
C9H11NO2
Exact mass
165.079
Mol weight
165.1891
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01674  Esterified local anesthetic
 DG01675  Local anesthetic
  DG01674  Esterified local anesthetic
Remark
Same as: C07527
Therapeutic category: 1212 2649 2710
ATC code: C05AD03 D02BA01 D04AB04 N01BA05 R02AD01
Chemical structure group: DG00379
Product (DG00379): D00552<JP/US>
Product (mixture): D04814<JP> D04816<JP> D04879<JP> D07742<JP>
Efficacy
Analgesic, Anesthetic (topical), Antipruritic
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Structure map
map07015  Local analgesics
map07110  Benzoic acid family
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD03 Benzocaine
      D00552  Benzocaine (USP/INN) <JP/US>
 D DERMATOLOGICALS
  D02 EMOLLIENTS AND PROTECTIVES
   D02B PROTECTIVES AGAINST UV-RADIATION
    D02BA Protectives against UV-radiation for topical use
     D02BA01 Aminobenzoic acid
      D00552  Benzocaine (USP/INN) <JP/US>
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB04 Benzocaine
      D00552  Benzocaine (USP/INN) <JP/US>
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BA Esters of aminobenzoic acid
     N01BA05 Benzocaine
      D00552  Benzocaine (USP/INN) <JP/US>
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AD Anesthetics, local
     R02AD01 Benzocaine
      D00552  Benzocaine (USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1212  Aminobenzoate alkyl esters
     D00552  Benzocaine (USP/INN); Ethyl aminobenzoate (JP17)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00552  Benzocaine (USP/INN); Ethyl aminobenzoate (JP17)
  27  Dental preparations
   271  Local anesthetics
    2710  Local anesthetics
     D00552  Benzocaine (USP/INN); Ethyl aminobenzoate (JP17)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for digestive organs
  15 Stomach pain and cramp relievers
   D00552  Benzocaine (USP/INN)
 Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D00552  Benzocaine (USP/INN)
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00552  Benzocaine (USP/INN)
 Agents for otolaryngologic use
  72 Other agents for otolaryngologic use
   D00552  Benzocaine (USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Ethyl aminobenzoate
    D00552  Benzocaine (USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Ethyl aminobenzoate
    D00552  Benzocaine (USP/INN)
 Third-class OTC drugs
  Inorganic and organic chemicals
   Ethyl aminobenzoate
    D00552  Benzocaine (USP/INN)
Pharmaceutical additives in Japan [BR:br08316]
 Soothing agent
  D00552  [001027] Ethyl aminobenzoate
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00552  Benzocaine (USP/INN) <JP/US>
    SCN2A
     D00552  Benzocaine (USP/INN) <JP/US>
    SCN3A
     D00552  Benzocaine (USP/INN) <JP/US>
    SCN4A
     D00552  Benzocaine (USP/INN) <JP/US>
    SCN5A
     D00552  Benzocaine (USP/INN) <JP/US>
    SCN8A
     D00552  Benzocaine (USP/INN) <JP/US>
    SCN9A
     D00552  Benzocaine (USP/INN) <JP/US>
    SCN10A
     D00552  Benzocaine (USP/INN) <JP/US>
    SCN11A
     D00552  Benzocaine (USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00552  Ethyl aminobenzoate
Drug classes of therapeutic agents [br08360.html]
 Anesthetics, analgesics and anti-inflammatory drugs
  D00552
BRITE hierarchy
Other DBs
CAS: 94-09-7
PubChem: 7847618
ChEBI: 116735
ChEMBL: CHEMBL278172
DrugBank: DB01086
LigandBox: D00552
NIKKAJI: J4.690F
LinkDB All DBs
KCF data Show

ATOM        12
            1   C8y C    20.6329  -17.3424
            2   C7a C    21.8450  -18.0357
            3   C8x C    20.6329  -15.9380
            4   C8x C    19.4209  -18.0416
            5   O7a O    23.0569  -17.3424
            6   O6a O    21.8450  -19.4401
            7   C8x C    19.4209  -15.2330
            8   C8x C    18.2148  -17.3481
            9   C1b C    24.2688  -18.0299
            10  C8y C    18.2089  -15.9380
            11  C1a C    25.4808  -17.3365
            12  N1a N    16.9911  -15.2388
BOND        12
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1
            11   10  12 1
            12    8  10 2

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