KEGG   DRUG: DapsoneHelp
Entry
D00592                      Drug                                   

Name
Dapsone (USP);
Diaphenylsulfone (JAN);
Aczone (TN)
Product
  Generic
Formula
C12H12N2O2S
Exact mass
248.0619
Mol weight
248.3009
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Enzyme substrate
 DG02855  CYP2E1 substrate
 DG01633  CYP3A substrate
Remark
Same as: C07666
Therapeutic category: 2699 6231
ATC code: D10AX05 J04BA02
Product: D00592<JP/US>
Efficacy
Antibacterial (leprostatic)
  Disease
Acne vulgaris [DS:H01445]
Dermatitis herpetiformis [DS:H01362]
Leprosy [DS:H00344]
Comment
Diaminodiphenylsulfone derivative
Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency [DS:H00668] are more prone to hemolysis with the use of Dapsone.
Suppression of dermatitis herpetiformis
Target
dihydropteroate synthase [KO:K00796]
  Pathway
ko00790  Folate biosynthesis
Metabolism
Enzyme: CYP2E1 [HSA:1571], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AX Other anti-acne preparations for topical use
     D10AX05 Dapsone
      D00592  Dapsone (USP) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J04 ANTIMYCOBACTERIALS
   J04B DRUGS FOR TREATMENT OF LEPRA
    J04BA Drugs for treatment of lepra
     J04BA02 Dapsone
      D00592  Dapsone (USP) <JP/US>
USP drug classification [BR:br08302]
 Antimycobacterials
  Antimycobacterials, Other
   Dapsone
    D00592  Dapsone (USP)
 Dermatological Agents
  Dapsone
   D00592  Dapsone (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   269  Miscellaneous
    2699  Others
     D00592  Dapsone (USP); Diaphenylsulfone (JAN)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   623  Leprostatics
    6231  Sulfones
     D00592  Dapsone (USP); Diaphenylsulfone (JAN)
Antiinfectives [br08350.html]
 Antibacterials
  D00592
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and germline mutations
  D00592
Prodrugs [br08324.html]
 D00592
BRITE hierarchy
Other DBs
CAS: 80-08-0
PubChem: 7847658
ChEBI: 4325
ChEMBL: CHEMBL1043
DrugBank: DB00250
LigandBox: D00592
NIKKAJI: J4.247A
LinkDB All DBs
KCF data Show

ATOM        17
            1   S4a S    21.9800  -14.6136
            2   C8y C    23.1922  -15.3246
            3   C8y C    20.7736  -15.3187
            4   O3c O    20.9776  -13.6228
            5   O3c O    22.9708  -13.6228
            6   C8x C    24.4045  -14.6195
            7   C8x C    23.1922  -16.7234
            8   C8x C    19.5614  -14.6136
            9   C8x C    20.7736  -16.7175
            10  C8x C    25.6050  -15.3187
            11  C8x C    24.4045  -17.4168
            12  C8x C    18.3433  -15.3187
            13  C8x C    19.5614  -17.4168
            14  C8y C    25.6167  -16.7234
            15  C8y C    18.3433  -16.7175
            16  N1a N    26.8174  -17.4285
            17  N1a N    17.1369  -17.4168
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     1   5 2
            5     2   6 2
            6     2   7 1
            7     3   8 2
            8     3   9 1
            9     6  10 1
            10    7  11 2
            11    8  12 1
            12    9  13 2
            13   10  14 2
            14   12  15 2
            15   14  16 1
            16   15  17 1
            17   11  14 1
            18   13  15 1

» Japanese version   » Back

DBGET integrated database retrieval system