KEGG   DRUG: Labetalol hydrochloride
Entry
D00600                      Drug                                   
Name
Labetalol hydrochloride (JP18/USP);
Normodyne (TN);
Trandate (TN)
Product
  Generic
LABETALOL HCL (A-S Medication Solutions), LABETALOL HCL (Bryant Ranch Prepack), LABETALOL HCL (Bryant Ranch Prepack), LABETALOL HCL (Bryant Ranch Prepack), LABETALOL HCL (Endo USA), LABETALOL HCL (HF Acquisition Co LLC), LABETALOL HCL (St. Mary's Medical Park Pharmacy), LABETALOL HYDROCHLORIDE (A-S Medication Solutions), LABETALOL HYDROCHLORIDE (A-S Medication Solutions), LABETALOL HYDROCHLORIDE (A-S Medication Solutions), LABETALOL HYDROCHLORIDE (A-S Medication Solutions), LABETALOL HYDROCHLORIDE (A-S Medication Solutions), LABETALOL HYDROCHLORIDE (A-S Medication Solutions), LABETALOL HYDROCHLORIDE (A-S Medication Solutions), LABETALOL HYDROCHLORIDE (A-S Medication Solutions), LABETALOL HYDROCHLORIDE (A-S Medication Solutions), LABETALOL HYDROCHLORIDE (A-S Medication Solutions), LABETALOL HYDROCHLORIDE (A-S Medication Solutions), LABETALOL HYDROCHLORIDE (A-S Medication Solutions), LABETALOL HYDROCHLORIDE (Actavis Pharma), LABETALOL HYDROCHLORIDE (Advagen Pharma), LABETALOL HYDROCHLORIDE (Advagen Pharma), LABETALOL HYDROCHLORIDE (American Health Packaging), LABETALOL HYDROCHLORIDE (Baxter Healthcare Corporation), LABETALOL HYDROCHLORIDE (Biocon Pharma), LABETALOL HYDROCHLORIDE (BluePoint Laboratories), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Cadila Pharmaceuticals Limited), LABETALOL HYDROCHLORIDE (Caplin Steriles Limited), LABETALOL HYDROCHLORIDE (Cardinal Health 107), LABETALOL HYDROCHLORIDE (Cardinal Health 107), LABETALOL HYDROCHLORIDE (Cardinal Health 107), LABETALOL HYDROCHLORIDE (Chartwell RX), LABETALOL HYDROCHLORIDE (Civica), LABETALOL HYDROCHLORIDE (Coupler LLC), LABETALOL HYDROCHLORIDE (Coupler LLC), LABETALOL HYDROCHLORIDE (Coupler LLC), LABETALOL HYDROCHLORIDE (Epic Pharma), LABETALOL HYDROCHLORIDE (Eywa Pharma), LABETALOL HYDROCHLORIDE (Fosun Pharma USA), LABETALOL HYDROCHLORIDE (Fosun Pharma USA), LABETALOL HYDROCHLORIDE (Gland Pharma Limited), LABETALOL HYDROCHLORIDE (Golden State Medical Supply), LABETALOL HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), LABETALOL HYDROCHLORIDE (Hikma Pharmaceuticals USA), LABETALOL HYDROCHLORIDE (Hikma Pharmaceuticals USA), LABETALOL HYDROCHLORIDE (Hospira), LABETALOL HYDROCHLORIDE (Hospira), LABETALOL HYDROCHLORIDE (Innogenix), LABETALOL HYDROCHLORIDE (Major Pharmaceuticals), LABETALOL HYDROCHLORIDE (Marlex Pharmaceuticals), LABETALOL HYDROCHLORIDE (Method Pharmaceuticals), LABETALOL HYDROCHLORIDE (NCS HealthCare of KY), LABETALOL HYDROCHLORIDE (NorthStar Rx LLC), LABETALOL HYDROCHLORIDE (Northwind Pharmaceuticals), LABETALOL HYDROCHLORIDE (Proficient Rx LP), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HYDROCHLORIDE (RedPharm Drug), LABETALOL HYDROCHLORIDE (Redpharm Drug), LABETALOL HYDROCHLORIDE (ST. MARY'S MEDICAL PARK PHARMACY), LABETALOL HYDROCHLORIDE (ST. MARY'S MEDICAL PARK PHARMACY), LABETALOL HYDROCHLORIDE (Sagent Pharmaceuticals), LABETALOL HYDROCHLORIDE (Unichem Pharmaceuticals (USA)), LABETALOL HYDROCHLORIDE (Zydus Lifesciences Limited), LABETALOL HYDROCHLORIDE (Zydus Pharmaceuticals USA)
Formula
C19H24N2O3. HCl
Exact mass
364.1554
Mol weight
364.86
Structure
Simcomp
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG03180  alpha1 and beta-Adrenergic receptor antagonist
 DG03231  Antihypertensive
  DG03180  alpha1 and beta-Adrenergic receptor antagonist
Remark
Therapeutic category: 2149
ATC code: C07AG01
Chemical structure group: DG00320
Product (DG00320): D00600<JP/US>
Efficacy
Antihypertensive, alpha1/beta-Adrenergic receptor antagonist
  Disease
Hypertension [DS:H01633]
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRB1 [HSA:153] [KO:K04141]
ADRB2 [HSA:154] [KO:K04142]
  Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Structure map
map07214  beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AG Alpha and beta blocking agents
     C07AG01 Labetalol
      D00600  Labetalol hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Beta-adrenergic Blocking Agents, Other
    Labetalol
     D00600  Labetalol hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00600  Labetalol hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG03180  alpha1 and beta-Adrenergic receptor antagonist
    DG00320  Labetalol
     D00600  Labetalol hydrochloride
  DG03231  Antihypertensive
   DG03180  alpha1 and beta-Adrenergic receptor antagonist
    DG00320  Labetalol
     D00600  Labetalol hydrochloride
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D00600  Labetalol hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00600  Labetalol hydrochloride (JP18/USP) <JP/US>
    ADRB1
     D00600  Labetalol hydrochloride (JP18/USP) <JP/US>
    ADRB2
     D00600  Labetalol hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00600  Labetalol hydrochloride
  D00600  Labetalol hydrochloride tablets
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG03180  alpha1 and beta-Adrenergic receptor antagonist
    DG00320  Labetalol
  DG03231  Antihypertensive
   DG03180  alpha1 and beta-Adrenergic receptor antagonist
    DG00320  Labetalol
Other DBs
CAS: 32780-64-6
PubChem: 7847666
ChEBI: 6344
LigandBox: D00600
NIKKAJI: J321.626H
LinkDB
KCF data

ATOM        25
            1   C8y C    13.1600  -15.8200
            2   C8y C    13.1600  -14.4200
            3   C8x C    14.3500  -13.7200
            4   C8x C    15.6100  -14.4200
            5   C8y C    15.6100  -15.8200
            6   C8x C    14.3500  -16.5200
            7   C1c C    16.8000  -16.5200
            8   C1b C    18.0600  -15.8200
            9   N1b N    19.2500  -16.5200
            10  C1c C    20.4400  -15.8200
            11  C1b C    21.7000  -16.5200
            12  C1b C    22.8900  -15.8200
            13  C8y C    24.0800  -16.5200
            14  C5a C    11.9700  -16.5200
            15  N1a N    10.7800  -15.8200
            16  O5a O    11.9700  -17.9200
            17  O1a O    11.9700  -13.7200
            18  O1a O    16.8000  -17.9200
            19  C1a C    20.4400  -14.4200
            20  C8x C    25.3400  -15.8200
            21  C8x C    26.5300  -16.5200
            22  C8x C    26.5300  -17.9200
            23  C8x C    25.3400  -18.6200
            24  C8x C    24.0800  -17.9200
            25  X   Cl   25.6900  -13.6500
BOND        25
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    1  14 1
            15   14  15 1
            16   14  16 2
            17    2  17 1
            18    7  18 1
            19   10  19 1
            20   13  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   13  24 1

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