KEGG   DRUG: Labetalol hydrochlorideHelp
Entry
D00600                      Drug                                   

Name
Labetalol hydrochloride (JP17/USP);
Normodyne (TN);
Trandate (TN)
Product
  Generic
LABETALOL HCL (American Health Packaging), LABETALOL HCL (BluePoint Laboratories), LABETALOL HCL (Bryant Ranch Prepack), LABETALOL HCL (Cardinal Health), LABETALOL HCL (Eon Labs), LABETALOL HCL (McKesson Corporation dba SKY Packaging), LABETALOL HCL (St. Mary's Medical Park Pharmacy), LABETALOL HYDROCHLORIDE (A-S Medication Solutions), LABETALOL HYDROCHLORIDE (Actavis Pharma), LABETALOL HYDROCHLORIDE (Akorn), LABETALOL HYDROCHLORIDE (Almaject), LABETALOL HYDROCHLORIDE (Alvogen), LABETALOL HYDROCHLORIDE (American Health Packaging), LABETALOL HYDROCHLORIDE (BluePoint Laboratories), LABETALOL HYDROCHLORIDE (Breckenridge Pharmaceutical), LABETALOL HCL (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Cadila Healthcare Limited), LABETALOL HYDROCHLORIDE (Cadila Pharmaceuticals Limited), LABETALOL HYDROCHLORIDE (Cardinal Health), LABETALOL HYDROCHLORIDE (Cardinal Health), LABETALOL HYDROCHLORIDE (Civica), LABETALOL HYDROCHLORIDE (Eywa Pharma), LABETALOL HYDROCHLORIDE (Fosun Pharma USA), LABETALOL HYDROCHLORIDE (Gland Pharma Limited), LABETALOL HYDROCHLORIDE (HF Acquisition Co LLC), LABETALOL HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), LABETALOL HYDROCHLORIDE (Hospira), LABETALOL HYDROCHLORIDE (Hospira), LABETALOL HYDROCHLORIDE (Major Pharmaceuticals), LABETALOL HYDROCHLORIDE (Method Pharmaceuticals), LABETALOL HCL (NCS HealthCare of KY), LABETALOL HCL (Par Pharmaceutical), LABETALOL HYDROCHLORIDE (Proficient Rx LP), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HCL (REMEDYREPACK), LABETALOL HYDROCHLORIDE (TWi Pharmaceuticals), LABETALOL HYDROCHLORIDE (West-Ward Pharmaceuticals Corp), LABETALOL HYDROCHLORIDE (West-Ward Pharmaceuticals Corp), LABETALOL HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C19H24N2O3. HCl
Exact mass
364.1554
Mol weight
364.8664
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
   DG01463  beta3-Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
Remark
Therapeutic category: 2149
ATC code: C07AG01
Chemical structure group: DG00320
Product (DG00320): D00600<JP/US>
Efficacy
Antihypertensive, alpha1/beta-Adrenergic receptor antagonist
  Disease
Hypertension [DS:H01633]
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRB1 [HSA:153] [KO:K04141]
ADRB2 [HSA:154] [KO:K04142]
  Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Drug interaction
Structure map
map07214  beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AG Alpha and beta blocking agents
     C07AG01 Labetalol
      D00600  Labetalol hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Beta-adrenergic Blocking Agents, Other
    Labetalol
     D00600  Labetalol hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00600  Labetalol hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00600  Labetalol hydrochloride (JP17/USP) <JP/US>
    ADRB1
     D00600  Labetalol hydrochloride (JP17/USP) <JP/US>
    ADRB2
     D00600  Labetalol hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00600  Labetalol hydrochloride
  D00600  Labetalol hydrochloride tablets
BRITE hierarchy
Other DBs
CAS: 32780-64-6
PubChem: 7847666
ChEBI: 6344
ChEMBL: CHEMBL1200323
DrugBank: DB00598
LigandBox: D00600
NIKKAJI: J321.626H
LinkDB All DBs
KCF data Show

ATOM        25
            1   C8y C    13.1600  -15.8200
            2   C8y C    13.1600  -14.4200
            3   C8x C    14.3500  -13.7200
            4   C8x C    15.6100  -14.4200
            5   C8y C    15.6100  -15.8200
            6   C8x C    14.3500  -16.5200
            7   C1c C    16.8000  -16.5200
            8   C1b C    18.0600  -15.8200
            9   N1b N    19.2500  -16.5200
            10  C1c C    20.4400  -15.8200
            11  C1b C    21.7000  -16.5200
            12  C1b C    22.8900  -15.8200
            13  C8y C    24.0800  -16.5200
            14  C5a C    11.9700  -16.5200
            15  N1a N    10.7800  -15.8200
            16  O5a O    11.9700  -17.9200
            17  O1a O    11.9700  -13.7200
            18  O1a O    16.8000  -17.9200
            19  C1a C    20.4400  -14.4200
            20  C8x C    25.3400  -15.8200
            21  C8x C    26.5300  -16.5200
            22  C8x C    26.5300  -17.9200
            23  C8x C    25.3400  -18.6200
            24  C8x C    24.0800  -17.9200
            25  X   Cl   25.6900  -13.6500
BOND        25
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    1  14 1
            15   14  15 1
            16   14  16 2
            17    2  17 1
            18    7  18 1
            19   10  19 1
            20   13  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   13  24 1

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