| Entry |
|
|---|
| Name |
Nitrendipine (JP18/USAN/INN);
Baypress (TN) |
|---|
| Formula |
C18H20N2O6
|
|---|
| Exact mass |
360.1321
|
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| Mol weight |
360.36
|
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| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 2171 |
|
|---|
| Efficacy |
Antihypertensive, Vasodilator, Calcium channel blocker |
|---|
| Comment |
Dihydropyridine derivative
|
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| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
|
|---|
| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA08 Nitrendipine
D00629 Nitrendipine (JP18/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
217 Vasodilators
2171 Coronary dilators
D00629 Nitrendipine (JP18/USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
D00629 Nitrendipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
D00629 Nitrendipine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00629 Nitrendipine
Drug classes [BR:br08332]
Cardiovascular agent
DG01928 Dihydropyridine calcium channel blocker
D00629 Nitrendipine
DG03231 Antihypertensive
D00629 Nitrendipine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D00629 Nitrendipine (JP18/USAN/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00629 Nitrendipine
D00629 Nitrendipine tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00629
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 26
1 C1y C 25.6841 -15.5925
2 C2y C 24.4825 -14.8986
3 C2y C 26.9031 -14.8986
4 C8y C 25.6782 -16.9923
5 C2y C 24.4825 -13.4930
6 C7a C 23.2752 -15.5868
7 C2y C 26.9031 -13.4930
8 C7a C 28.1161 -15.5925
9 C8x C 24.4651 -17.6981
10 C8x C 26.8914 -17.6981
11 N1x N 25.6841 -12.7931
12 C1a C 23.2752 -12.7815
13 O7a O 22.0622 -14.8926
14 O6a O 23.2812 -16.9923
15 C1a C 28.1221 -12.7931
16 O7a O 29.3294 -14.8986
17 O6a O 28.1221 -16.9982
18 C8y C 24.4651 -19.0979
19 C8x C 26.8914 -19.1037
20 C1b C 20.8491 -15.5809
21 C1a C 30.5424 -15.5925
22 C8x C 25.6724 -19.7977
23 N2b N 23.2578 -19.7977 #+
24 C1a C 19.6359 -14.8811
25 O3a O 22.0447 -19.0920
26 O3a O 23.2695 -21.1974 #-
BOND 27
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 4 10 2
10 5 11 1
11 5 12 1
12 6 13 1
13 6 14 2
14 7 15 1
15 8 16 1
16 8 17 2
17 9 18 2
18 10 19 1
19 13 20 1
20 16 21 1
21 18 22 1
22 18 23 1
23 20 24 1
24 23 25 2
25 23 26 1
26 7 11 1
27 19 22 2
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