| Entry |
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| Name |
Quinidine polygalacturonate;
Cardioquin (TN) |
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| Formula |
C20H24N2O2. (C6H10O7)mon
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Product (DG00192): | D00642<US> D02272<JP/US> |
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| Efficacy |
Antiarrhythmic, Sodium channel blocker |
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| Target |
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| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01B ANTIARRHYTHMICS, CLASS I AND III
C01BA Antiarrhythmics, class Ia
C01BA01 Quinidine
D00643 Quinidine polygalacturonate
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG00192 Quinidine
D00643 Quinidine polygalacturonate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00192 Quinidine
D00643 Quinidine polygalacturonate
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D00643 Quinidine polygalacturonate
SCN2A
D00643 Quinidine polygalacturonate
SCN3A
D00643 Quinidine polygalacturonate
SCN4A
D00643 Quinidine polygalacturonate
SCN5A
D00643 Quinidine polygalacturonate
SCN8A
D00643 Quinidine polygalacturonate
SCN9A
D00643 Quinidine polygalacturonate
SCN10A
D00643 Quinidine polygalacturonate
SCN11A
D00643 Quinidine polygalacturonate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00643
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG00192 Quinidine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00192 Quinidine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 37
1 C8y C 15.8200 -25.3400
2 C8y C 17.0100 -24.6400
3 C8y C 15.8200 -26.7400
4 C8x C 14.5600 -24.6400
5 C1c C 17.0100 -23.2400
6 C8x C 18.2000 -25.3400
7 C8x C 14.5600 -27.4400
8 N5x N 17.0100 -27.4400
9 C8y C 13.3700 -25.3400
10 C1y C 18.2700 -22.5400
11 O1a O 15.8200 -22.5400
12 C8x C 18.2000 -26.7400
13 C8x C 13.3700 -26.7400
14 O2a O 12.1800 -24.6400
15 N1y N 19.6700 -21.6300
16 C1x C 17.5000 -21.4900
17 C1a C 12.1800 -23.2400
18 C1x C 19.6700 -20.4400
19 C1x C 21.2100 -22.4700
20 C1y C 18.9000 -20.6500
21 C1y C 18.9000 -19.6700
22 C1x C 20.5100 -21.3500
23 C2b C 18.4100 -18.3400
24 C2a C 19.2500 -17.2200
25 C1c C 26.9500 -26.0400
26 C1c C 25.7600 -25.4100
27 C1c C 28.1400 -25.4100
28 O1a O 26.9500 -27.5100
29 C1c C 24.5000 -26.0400
30 O1a O 25.7600 -23.9400
31 C6a C 29.4000 -26.0400
32 O1a O 28.1400 -23.9400
33 C4a C 23.3100 -25.4100
34 O1a O 24.5000 -27.5100
35 O6a O 30.5900 -25.4100
36 O6a O 29.4000 -27.5100
37 O4a O 22.1200 -26.0400
BOND 39
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 2
6 3 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 5 11 1 #Down
11 6 12 1
12 7 13 1
13 9 14 1
14 10 15 1
15 10 16 1
16 14 17 1
17 15 18 1
18 15 19 1
19 16 20 1
20 18 21 1
21 19 22 1
22 21 23 1 #Up
23 23 24 2
24 8 12 2
25 9 13 2
26 20 21 1
27 20 22 1
28 25 26 1
29 25 27 1
30 25 28 1 #Down
31 26 29 1
32 26 30 1 #Up
33 27 31 1
34 27 32 1 #Down
35 29 33 1
36 29 34 1 #Up
37 31 35 1
38 31 36 2
39 33 37 2
BRACKET 1 21.4200 -28.5600 21.4200 -23.1000
1 32.4800 -23.1000 32.4800 -28.5600
1 MON
ORIGINAL 1 26 27 28 29 30 31 32 33 34 35 36 37 38
REPEAT 1
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