KEGG   DRUG: FomepizoleHelp
Entry
D00707                      Drug                                   

Name
Fomepizole (JAN/USAN/INN);
Antizol (TN)
Product
  Generic
Formula
C4H6N2
Exact mass
82.0531
Mol weight
82.1038
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Enzyme inhibitor
 DG01634  CYP1A2 inhibitor
 DG01525  CYP2A6 inhibitor
 DG01643  CYP2C9 inhibitor
 DG01645  CYP2D6 inhibitor
 DG02884  CYP2E1 inhibitor
 DG02852  CYP3A inhibitor
  DG01522  CYP3A4 inhibitor
 DG01522  CYP3A4 inhibitor
Remark
Same as: C07837
Therapeutic category: 3929
ATC code: V03AB34
Product: D00707<JP/US>
Efficacy
Antidote (ethyleneglycol, methanol), Alcohol dehydrogenase inhibitor
Target
ADH [HSA:124 125 126] [KO:K13951]
  Pathway
hsa00980  Metabolism of xenobiotics by cytochrome P450
Interaction
CYP inhibition: CYP2D6 [HSA:1565], CYP2E1 [HSA:1571], CYP1A2 [HSA:1544], CYP2A6 [HSA:1548], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB34 Fomepizole
      D00707  Fomepizole (JAN/USAN/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   392  Antidotes
    3929  Others
     D00707  Fomepizole (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    ADH
     D00707  Fomepizole (JAN/USAN/INN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00707
BRITE hierarchy
Other DBs
CAS: 7554-65-6
PubChem: 7847772
ChEBI: 5141
ChEMBL: CHEMBL1308
DrugBank: DB01213
PDB-CCD: 4PZ[PDBj]
LigandBox: D00707
NIKKAJI: J35.396E
LinkDB All DBs
KCF data Show

ATOM        6
            1   C8y C    21.8459  -16.2459
            2   C8x C    23.2400  -16.2459
            3   C8x C    21.4084  -14.9216
            4   C1a C    20.8425  -17.2317
            5   N5x N    23.6775  -14.9216
            6   N4x N    22.5459  -14.0931
BOND        6
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     5   6 1

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