KEGG   DRUG: Thalidomide
Entry
D00754                      Drug                                   
Name
Thalidomide (JAN/USP/INN);
Thalomid (TN);
Thaled (TN)
Product
THALOMID (Celgene Corporation)
Formula
C13H10N2O4
Exact mass
258.0641
Mol weight
258.23
Structure
Simcomp
Remark
Same as: C07910
Therapeutic category: 1290 4291 6239
ATC code: L04AX02
Product: D00754<JP/US>
Efficacy
Antibiotic, Antineoplastic
  Disease
Multiple myeloma [DS:H00010]
Erythema nodosum leprosum [DS:H01473]
Target
TNF (TNFA, TNFSF2) [HSA:7124] [KO:K03156]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04064  NF-kappa B signaling pathway
hsa04640  Hematopoietic cell lineage
hsa04668  TNF signaling pathway
Interaction
Structure map
map07032  Hypnotics
map07046  Immunosuppressive agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AX Other immunosuppressants
     L04AX02 Thalidomide
      D00754  Thalidomide (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Immunomodulatory Agents
   Thalidomide
    D00754  Thalidomide (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   129  Miscellaneous
    1290  Miscellaneous
     D00754  Thalidomide (JAN/USP/INN)
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D00754  Thalidomide (JAN/USP/INN)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   623  Leprostatics
    6239  Others
     D00754  Thalidomide (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNF (TNFA, TNFSF2)
     D00754  Thalidomide (JAN/USP/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00754
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00754
Other DBs
CAS: 50-35-1
PubChem: 7847819
ChEBI: 9513
LigandBox: D00754
NIKKAJI: J4.101G
LinkDB
KCF data

ATOM        19
            1   N1y N    24.4297  -17.9205
            2   C1y C    25.8285  -17.9088
            3   C5x C    23.6163  -19.0616
            4   C5x C    23.6046  -16.7910
            5   C5x C    26.5422  -16.6857
            6   C1x C    26.5482  -19.1142
            7   C8y C    22.2821  -18.6228
            8   O5x O    24.0552  -20.3841
            9   C8y C    22.2763  -17.2300
            10  O5x O    24.0260  -15.4627
            11  N1x N    27.9293  -16.6506
            12  O5x O    25.8168  -15.4684
            13  C1x C    27.9761  -19.0791
            14  C8x C    21.0825  -19.3248
            15  C8x C    21.0590  -16.5452
            16  C5x C    28.6490  -17.8560
            17  C8x C    19.8653  -18.6402
            18  C8x C    19.8594  -17.2475
            19  O5x O    30.0477  -17.8326
BOND        21
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     4  10 2
            10    5  11 1
            11    5  12 2
            12    6  13 1
            13    7  14 1
            14    9  15 1
            15   11  16 1
            16   14  17 2
            17   15  18 2
            18   16  19 2
            19    7   9 2
            20   13  16 1
            21   17  18 1

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