KEGG   DISEASE: Erythema nodosum leprosum
Entry
H01473                      Disease                                
Name
Erythema nodosum leprosum
Description
Reactional states of leprosy are expressions of immunological disturbance and are generally divided into two variants: type 1 (Jopling's type I or reversal reaction) and type 2 (Jopling's type II reaction). Erythema Nodosum Leprosum (ENL), the main symptom of a type-2 reaction in leprosy, is caused by a humoral immune response to Mycobacterium leprae. Patients with ENL become acutely sick with fever, malaise, and crops of painful erythematous nodules. Inflammation often affects other systems causing iritis, neuritis, myositis, lymphadenitis, arthritis, dactylitis, and orchitis.
Category
Skin and soft tissue diseases
Brite
Human diseases [BR:br08402]
 Skin diseases
  Skin and soft tissue diseases
   H01473  Erythema nodosum leprosum
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Mycobacterial diseases
   1B20  Leprosy
    H01473  Erythema nodosum leprosum
Pathogen
Mycobacterium leprae [GN:mle mlb]
Drug
Thalidomide [DR:D00754]
Comment
See also H00344 Leprosy.
Other DBs
ICD-11: 1B20.21
ICD-10: A30.8 L52
MeSH: D004893
Reference
  Authors
Pocaterra L, Jain S, Reddy R, Muzaffarullah S, Torres O, Suneetha S, Lockwood DN
  Title
Clinical course of erythema nodosum leprosum: an 11-year cohort study in Hyderabad, India.
  Journal
Am J Trop Med Hyg 74:868-79 (2006)
DOI:10.4269/ajtmh.2006.74.868
Reference
  Authors
Voorend CG, Post EB
  Title
A systematic review on the epidemiological data of erythema nodosum leprosum, a type 2 leprosy reaction.
  Journal
PLoS Negl Trop Dis 7:e2440 (2013)
DOI:10.1371/journal.pntd.0002440
Reference
  Authors
Travassos AR, Antunes J, Pacheco D, Almeida LS, Filipe P, Marques MS
  Title
Erythema nodosum leprosum associated with minocycline.
  Journal
Acta Dermatovenerol Alp Pannonica Adriat 21:39-41 (2012)
DOI:10.2478/v10162-012-0011-6
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