Reactional states of leprosy are expressions of immunological disturbance and are generally divided into two variants: type 1 (Jopling's type I or reversal reaction) and type 2 (Jopling's type II reaction). Erythema Nodosum Leprosum (ENL), the main symptom of a type-2 reaction in leprosy, is caused by a humoral immune response to Mycobacterium leprae. Patients with ENL become acutely sick with fever, malaise, and crops of painful erythematous nodules. Inflammation often affects other systems causing iritis, neuritis, myositis, lymphadenitis, arthritis, dactylitis, and orchitis.
Category
Bacterial infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
01 Certain infectious or parasitic diseases
Mycobacterial diseases
1B20 Leprosy
H01473 Erythema nodosum leprosum
14 Diseases of the skin
Inflammatory dermatoses
Inflammatory erythemas and other reactive inflammatory dermatoses
EB31 Erythema nodosum
H01473 Erythema nodosum leprosum
Genome-based classification of infectious diseases [BR:br08401]
Bacterial infections
Infections caused by actinobacteria
H01473 Erythema nodosum leprosum
