KEGG   DRUG: Succinylcholine chloride
Entry
D00766                      Drug                                   

Name
Succinylcholine chloride (USP);
Suxamethonium chloride (INN);
Anectine (TN);
Quelicin (TN)
Product
  Generic
SUCCINYLCHOLINE (Dr.Reddy's Laboratories Inc.,), SUCCINYLCHOLINE (Medical Purchasing Solutions), SUCCINYLCHOLINE CHLORIDE (Accord Healthcare), SUCCINYLCHOLINE CHLORIDE (Amneal Pharmaceuticals LLC), SUCCINYLCHOLINE CHLORIDE (Amring Pharmaceuticals), SUCCINYLCHOLINE CHLORIDE (Amring Pharmaceuticals), SUCCINYLCHOLINE CHLORIDE (BluePoint Laboratories), SUCCINYLCHOLINE CHLORIDE (Breckenridge Pharmaceutical), SUCCINYLCHOLINE CHLORIDE (Cadila Healthcare Limited), SUCCINYLCHOLINE CHLORIDE (Camber Pharmaceuticals), SUCCINYLCHOLINE CHLORIDE (Devatis), SUCCINYLCHOLINE CHLORIDE (Fresenius Kabi USA), SUCCINYLCHOLINE CHLORIDE (General Injectables & Vaccines), SUCCINYLCHOLINE CHLORIDE (General Injectables and Vaccines), SUCCINYLCHOLINE CHLORIDE (Gland Pharma Limited), SUCCINYLCHOLINE CHLORIDE (HF Acquisition Co LLC), SUCCINYLCHOLINE CHLORIDE (Indoco Remedies Limited), SUCCINYLCHOLINE CHLORIDE (Liva Pharmaceuticals Limited), SUCCINYLCHOLINE CHLORIDE (Medical Purchasing Solutions), SUCCINYLCHOLINE CHLORIDE (Medical Purchasing Solutions), SUCCINYLCHOLINE CHLORIDE (Medical Purchasing Solutions), SUCCINYLCHOLINE CHLORIDE (Micro Labs Limited), SUCCINYLCHOLINE CHLORIDE (Nexus Pharmaceuticals), SUCCINYLCHOLINE CHLORIDE (Nivagen Pharmaceuticals), SUCCINYLCHOLINE CHLORIDE (Piramal Critical Care), SUCCINYLCHOLINE CHLORIDE (Renaissance Lakewood LLC), SUCCINYLCHOLINE CHLORIDE (STI Pharma LLC), SUCCINYLCHOLINE CHLORIDE (Somerset Therapeutics), SUCCINYLCHOLINE CHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C14H30N2O4. 2Cl
Exact mass
360.1583
Mol weight
361.305
Structure
Simcomp
Class
Other
 DG02029  Muscle relaxant
  DG01696  Peripherally-acting muscle relaxant
   DG01742  Quaternary ammonium compound type muscle relaxant
 DG01696  Peripherally-acting muscle relaxant
  DG01742  Quaternary ammonium compound type muscle relaxant
Remark
ATC code: M03AB01
Chemical structure group: DG00768
Product (DG00768): D00766<US> D02275<JP>
Efficacy
Muscle relaxant
Comment
neuromuscular depolarizing agent
Choline derivative
Target
CHRN (muscle type) [HSA:1134 1140 1144 1145 1146] [KO:K04803 K04812 K04816 K04817 K04818]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07221  Nicotinic cholinergic receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M03 MUSCLE RELAXANTS
   M03A MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS
    M03AB Choline derivatives
     M03AB01 Suxamethonium
      D00766  Succinylcholine chloride (USP) <US>
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Acetylcholine (nicotinic)
    CHRN (muscle type)
     D00766  Succinylcholine chloride (USP) <US>
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00766
Other DBs
CAS: 71-27-2
PubChem: 7847831
ChEBI: 61219
ChEMBL: CHEMBL983
DrugBank: DB00202
LigandBox: D00766
NIKKAJI: J252.877K
LinkDB
KCF data

ATOM        22
            1   N1d N    19.6034  -17.2375 #+
            2   C1b C    20.8172  -17.9319
            3   C1b C    22.0310  -17.2316
            4   O7a O    23.2390  -17.9202
            5   C7a C    24.4527  -17.2259
            6   C1b C    25.6666  -17.9145
            7   O6a O    24.4469  -15.8194
            8   C1b C    26.8743  -17.2142
            9   C7a C    28.0882  -17.9085
            10  O7a O    29.2962  -17.2083
            11  O6a O    28.0765  -19.3091
            12  C1b C    30.5099  -17.9028
            13  C1b C    31.7238  -17.2025
            14  N1d N    32.9375  -17.9028 #+
            15  C1a C    34.1499  -18.6028
            16  C1a C    33.6377  -16.6895
            17  C1a C    32.2386  -19.1138
            18  C1a C    18.3910  -16.5375
            19  C1a C    18.9125  -18.4396
            20  C1a C    20.3078  -16.0121
            21  X   Cl   32.0617  -14.6991 #-
            22  X   Cl   19.3642  -14.2730 #-
BOND        19
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     5   7 2
            7     6   8 1
            8     8   9 1
            9     9  10 1
            10    9  11 2
            11   10  12 1
            12   12  13 1
            13   13  14 1
            14   14  15 1
            15   14  16 1
            16   14  17 1
            17    1  18 1
            18    1  19 1
            19    1  20 1

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KEGG   DRUG: Suxamethonium chloride hydrate
Entry
D02275                      Drug                                   

Name
Suxamethonium chloride hydrate (JP17);
Suxamethonium chloride dihydrate;
Succin (TN)
Formula
C14H30N2O4. 2H2O. 2Cl
Exact mass
396.1794
Mol weight
397.3356
Structure
Simcomp
Class
Other
 DG02029  Muscle relaxant
  DG01696  Peripherally-acting muscle relaxant
   DG01742  Quaternary ammonium compound type muscle relaxant
 DG01696  Peripherally-acting muscle relaxant
  DG01742  Quaternary ammonium compound type muscle relaxant
Remark
Therapeutic category: 1224
ATC code: M03AB01
Chemical structure group: DG00768
Product (DG00768): D00766<US> D02275<JP>
Efficacy
Muscle relaxant
Comment
Choline derivative
Target
CHRN (muscle type) [HSA:1134 1140 1144 1145 1146] [KO:K04803 K04812 K04816 K04817 K04818]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07221  Nicotinic cholinergic receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M03 MUSCLE RELAXANTS
   M03A MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS
    M03AB Choline derivatives
     M03AB01 Suxamethonium
      D02275  Suxamethonium chloride hydrate (JP17) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   122  Skeletal muscle relaxants
    1224  Cholines
     D02275  Suxamethonium chloride hydrate (JP17)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Acetylcholine (nicotinic)
    CHRN (muscle type)
     D02275  Suxamethonium chloride hydrate (JP17) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02275  Suxamethonium chloride hydrate
  D02275  Suxamethonium chloride injection
  D02275  Suxamethonium chloride for injection
Other DBs
CAS: 6101-15-1
PubChem: 7849334
DrugBank: DB00202
LigandBox: D02275
LinkDB
KCF data

ATOM        24
            1   O0  O    36.1482  -17.7472
            2   N1d N    17.1667  -17.6692 #+
            3   C1b C    18.3814  -18.3641
            4   C1b C    19.5960  -17.6633
            5   O7a O    20.8048  -18.3524
            6   C7a C    22.0193  -17.6576
            7   C1b C    23.2341  -18.3467
            8   O6a O    22.0835  -16.2502
            9   C1b C    24.4426  -17.6459
            10  C7a C    25.6573  -18.3407
            11  O7a O    26.8661  -17.6400
            12  O6a O    25.7156  -19.7422
            13  C1b C    28.0807  -18.3350
            14  C1b C    29.2954  -17.6342
            15  N1d N    30.5099  -18.3350 #+
            16  C1a C    31.7231  -19.0355
            17  C1a C    31.2106  -17.1209
            18  C1a C    29.8105  -19.5468
            19  C1a C    15.9535  -16.9688
            20  C1a C    16.4754  -18.8721
            21  C1a C    17.8716  -16.4430
            22  X   Cl   29.6335  -15.1291 #-
            23  X   Cl   16.9274  -14.7027 #-
            24  O0  O    36.1482  -17.7472
BOND        19
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     6   8 2
            7     7   9 1
            8     9  10 1
            9    10  11 1
            10   10  12 2
            11   11  13 1
            12   13  14 1
            13   14  15 1
            14   15  16 1
            15   15  17 1
            16   15  18 1
            17    2  19 1
            18    2  20 1
            19    2  21 1
BRACKET     1    34.4400  -18.6900   34.4400  -16.8000
            1    36.5400  -16.8000   36.5400  -18.6900
            1  2
 ORIGINAL  1    1
 REPEAT    1   24

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