KEGG   Homo sapiens (human): 1145
Entry
1145              CDS       T01001                                 
Symbol
CHRNE, ACHRE, CMS1A1, CMS1D, CMS1E, CMS2A, CMS4A, CMS4B, CMS4C, FCCMS, FIM1, FIMG, FIMG1, MGI, SCCMS
Name
(RefSeq) cholinergic receptor nicotinic epsilon subunit
  KO
K04817  nicotinic acetylcholine receptor epsilon
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Disease
H00770  Congenital myasthenic syndrome
Drug target
Acetylcholine (DG01133): D00999<JP/US>
Cytisinicline: D07770
Gantacurium chloride: D04303
Lobeline (DG01287): D02202 D02364 D08138
Mecamylamine (DG00252): D00611<US>
Metocurine iodide: D00761
Nicotine (DG00994): D03365<JP/US> D05156 D05157
Suxamethonium (DG00768): D00766<US> D02275<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1145 (CHRNE)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    1145 (CHRNE)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Acetylcholine (nicotinic)
   1145 (CHRNE)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 1145
NCBI-ProteinID: NP_000071
OMIM: 100725
HGNC: 1966
Ensembl: ENSG00000108556
UniProt: Q04844
LinkDB
Position
17:complement(4897771..4908677)
AA seq 493 aa
MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNL
ISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQF
GVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTF
AVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKP
LFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLS
VPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPP
EAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEV
RCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFN
RVPDLPYAPCIQP
NT seq 1482 nt   +upstreamnt  +downstreamnt
atggcaagggctccgcttggggtcctgctcctcttggggcttctcggcaggggtgtgggg
aagaacgaggaactgcgtctttatcaccatctcttcaacaactatgacccaggaagccgg
ccagtgcgggagcctgaggatactgtcaccatcagcctcaaggtcaccctgacgaatctc
atctcactgaatgaaaaagaggagactctcaccactagcgtctggattggaatcgattgg
caggattaccgactcaactacagcaaggacgactttgggggtatagaaaccctgcgagtc
ccttcagaactcgtgtggctgccagagattgtgctggaaaacaatattgatggccagttc
ggagtggcctacgacgccaacgtgctcgtctacgagggcggctccgtgacgtggctgcct
ccggccatctaccgcagcgtctgcgcagtggaggtcacctacttccccttcgattggcag
aactgttcgcttattttccgctctcagacgtacaatgccgaagaggtggagttcactttt
gccgtagacaacgacggcaagaccatcaacaagatcgacatcgacacagaggcctatact
gagaacggcgagtgggccatcgacttctgcccgggggtgatccgccgccaccacggtggc
gccaccgacggcccaggggagactgacgtcatctactcgctcatcatccgccggaagccg
ctcttctacgtcattaacatcatcgtgccctgtgtgctcatctcgggcctggtgctgctc
gcctacttcctgccggcgcaggccggcggccagaaatgcacggtctccatcaacgtcctg
ctcgcccagaccgtcttcttgttcctcattgcccagaaaatcccagagacttctctgagc
gtgccgctcctgggcaggttccttattttcgtcatggtggtcgccacgctcattgtcatg
aattgcgtcatcgtgctcaacgtgtcccagcggacgcccaccacccacgccatgtccccg
cggctgcgccacgttctcctggagctgctgccgcgcctcctgggctccccgccgccgccc
gaggccccccgggccgcctcgcccccaaggcgggcgtcgtcggtgggcttattgctccgc
gcggaggagctgatactgaaaaagccacggagcgagctcgtgtttgaggggcagaggcac
cggcaggggacctggacggctgccttctgccagagcctgggcgccgccgcccccgaggtc
cgctgctgtgtggatgccgtgaacttcgtggccgagagcacgagagatcaggaggccacc
ggcgaggaagtgtccgactgggtgcgcatggggaatgcccttgacaacatctgcttctgg
gccgctctggtgctcttcagcgtgggctccagcctcatcttcctcggggcctacttcaac
cgagtgcctgatctcccctacgcgccgtgtatccagccttag

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