KEGG   DRUG: SparteineHelp
Entry
D01041                      Drug                                   

Name
Sparteine (INN)
Formula
C15H26N2
Exact mass
234.2096
Mol weight
234.3803
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Source
Sarothmus scoparius [TAX:3835]
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C10783
ATC code: C01BA04
Chemical structure group: DG00195
Efficacy
Antiarrhythmic, Oxytocic, Sodium channel blocker
Comment
Alkaloid
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA04 Sparteine
      D01041  Sparteine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D01041  Sparteine (INN)
    SCN2A
     D01041  Sparteine (INN)
    SCN3A
     D01041  Sparteine (INN)
    SCN4A
     D01041  Sparteine (INN)
    SCN5A
     D01041  Sparteine (INN)
    SCN8A
     D01041  Sparteine (INN)
    SCN9A
     D01041  Sparteine (INN)
    SCN10A
     D01041  Sparteine (INN)
    SCN11A
     D01041  Sparteine (INN)
BRITE hierarchy
Other DBs
CAS: 90-39-1
PubChem: 7848104
ChEBI: 28827
LigandBox: D01041
NIKKAJI: J4.317F
LinkDB All DBs
KCF data Show

ATOM        17
            1   C1x C    26.2779   -7.0608
            2   C1x C    26.2779   -8.4571
            3   C1x C    27.4901   -9.1554
            4   C1x C    27.4901   -6.3625
            5   C1y C    28.6953   -7.0608
            6   N1y N    28.6893   -8.4571
            7   C1x C    29.8957   -9.1605
            8   C1y C    31.1079   -8.4675
            9   C1x C    31.1138   -7.0711
            10  C1y C    29.9075   -6.3676
            11  C1x C    31.1089   -5.6573
            12  N1y N    32.3219   -6.3414
            13  C1y C    32.3078   -7.7589
            14  C1x C    33.5284   -8.4798
            15  C1x C    34.7631   -7.7834
            16  C1x C    34.8004   -6.3657
            17  C1x C    33.5566   -5.6447
BOND        20
            1     8   9 1 #Up
            2    10   9 1 #Up
            3    10   5 1
            4    10  11 1
            5     8  13 1
            6    11  12 1
            7     1   2 1
            8     2   3 1
            9     3   6 1
            10    5   4 1
            11    4   1 1
            12    5   6 1
            13    6   7 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  12 1
            20    7   8 1

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