| Entry |
|
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| Name |
Barnidipine hydrochloride (JAN);
Hypoca (TN) |
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| Formula |
C27H29N3O6. HCl
|
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| Exact mass |
527.1823
|
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| Mol weight |
527.99
|
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| Structure |
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 2149 |
| Product (DG00325): | D01104<JP> |
|
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| Efficacy |
Antihypertensive, Calcium channel blocker |
|---|
| Comment |
Dihydropyridine derivative
|
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| Target |
|
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| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA12 Barnidipine
D01104 Barnidipine hydrochloride (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D01104 Barnidipine hydrochloride (JAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00325 Barnidipine
D01104 Barnidipine hydrochloride
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG00325 Barnidipine
D01104 Barnidipine hydrochloride
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00325 Barnidipine
D01104 Barnidipine hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG01928 Dihydropyridine calcium channel blocker
D01104 Barnidipine hydrochloride
DG03231 Antihypertensive
D01104 Barnidipine hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D01104 Barnidipine hydrochloride (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01104
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00325 Barnidipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG00325 Barnidipine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00325 Barnidipine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 37
1 C1b C 25.6682 -17.6897
2 N1y N 24.4554 -16.9903
3 C1x C 24.8899 -15.6640
4 C1x C 23.7540 -14.8378
5 C1y C 22.6182 -15.6640
6 C1x C 23.0539 -16.9947
7 C2y C 16.5561 -13.5665
8 C2y C 16.5561 -14.9666
9 C1y C 17.7716 -15.6667
10 C2y C 18.9800 -14.9666
11 C2y C 18.9800 -13.5665
12 N1x N 17.7716 -12.8664
13 C8y C 17.7733 -17.0669
14 C8x C 16.5678 -17.7636
15 C8x C 16.5695 -19.1637
16 C8x C 17.7830 -19.8623
17 C8y C 18.9948 -19.1607
18 C8x C 18.9929 -17.7605
19 C7a C 20.1930 -15.6657
20 O6a O 20.1942 -17.0659
21 O7a O 21.4051 -14.9648
22 C1a C 20.1930 -12.8672
23 C1a C 15.3438 -12.8657
24 C7a C 15.3438 -15.6672
25 O7a O 14.1308 -14.9678
26 O6a O 15.3445 -17.0674
27 C1a C 12.9187 -15.6686
28 N2b N 20.2083 -19.8592 #+
29 O3a O 20.2100 -21.2594 #-
30 O3a O 21.7699 -18.8076
31 C8y C 25.6691 -19.0899
32 C8x C 24.4548 -19.7857
33 C8x C 24.4554 -21.1859
34 C8x C 25.6684 -21.8853
35 C8x C 26.8807 -21.1846
36 C8x C 26.8799 -19.7844
37 X Cl 29.5324 -17.7882
BOND 39
1 17 18 1
2 18 13 2
3 3 4 1
4 10 19 1
5 4 5 1
6 19 20 2
7 7 8 2
8 19 21 1
9 5 21 1 #Up
10 8 9 1
11 11 22 1
12 9 10 1
13 7 23 1
14 10 11 2
15 8 24 1
16 11 12 1
17 24 25 1
18 12 7 1
19 24 26 2
20 5 6 1
21 25 27 1
22 9 13 1 #Up
23 17 28 1
24 6 2 1
25 28 29 1
26 28 30 2
27 1 2 1
28 1 31 1
29 2 3 1
30 13 14 1
31 14 15 2
32 15 16 1
33 31 32 2
34 32 33 1
35 33 34 2
36 34 35 1
37 35 36 2
38 36 31 1
39 16 17 2
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