KEGG   DRUG: Azelnidipine
Entry
D01145                      Drug                                   
Name
Azelnidipine (JP18/INN);
Calblock (TN)
Formula
C33H34N4O6
Exact mass
582.2478
Mol weight
582.6463
Structure
Simcomp
Class
Cardiovascular agent
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
 DG03231  Antihypertensive
  DG01928  Dihydropyridine calcium channel blocker
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2149
Product: D01145<JP>
Product (mixture): D09594<JP>
Efficacy
Antihypertensive, Calcium channel blocker
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07036  Calcium channel blocking drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01145  Azelnidipine (JP18/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01496  Calcium channel L type blocker
    D01145  Azelnidipine
  DG03231  Antihypertensive
   DG01928  Dihydropyridine calcium channel blocker
    D01145  Azelnidipine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D01145  Azelnidipine
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01928  Dihydropyridine calcium channel blocker
   D01145  Azelnidipine
  DG03231  Antihypertensive
   D01145  Azelnidipine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-L
     D01145  Azelnidipine (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01145  Azelnidipine
  D01145  Azelnidipine tablets
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01145
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01145
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01145
Other DBs
CAS: 123524-52-7
PubChem: 7848208
ChEBI: 31247
LigandBox: D01145
NIKKAJI: J429.875F
LinkDB
KCF data

ATOM        43
            1   C1c C    30.2706  -18.7179
            2   C8y C    30.2638  -20.1079
            3   C8y C    31.4780  -18.0290
            4   N1y N    29.0705  -18.0169
            5   C1y C    27.6806  -16.6268
            6   C1x C    27.6806  -18.0169
            7   C1x C    29.0705  -16.6268
            8   C2y C    21.6713  -14.5489
            9   C2y C    21.6713  -15.9390
            10  C1y C    22.8779  -16.6340
            11  C2y C    24.0775  -15.9390
            12  C2y C    24.0775  -14.5489
            13  N1x N    22.8779  -13.8540
            14  C8y C    22.8798  -18.0240
            15  C8x C    21.6831  -18.7156
            16  C8x C    21.6848  -20.1055
            17  C8x C    22.8894  -20.7990
            18  C8y C    24.0924  -20.1025
            19  C8x C    24.0905  -18.7125
            20  C7a C    20.4708  -16.6340
            21  O7a O    19.2704  -15.9390
            22  C1c C    18.0699  -16.6340
            23  C1a C    16.8695  -15.9390
            24  O6a O    20.4708  -18.0240
            25  C1a C    18.0699  -18.0240
            26  C1a C    20.4680  -13.8533
            27  N1a N    25.2818  -13.8549
            28  C7a C    25.2726  -16.6268
            29  O7a O    26.4731  -15.9319
            30  C8x C    32.6697  -18.7334
            31  C8x C    33.8770  -18.0445
            32  C8x C    33.8841  -16.6545
            33  C8x C    32.6838  -15.9535
            34  C8x C    31.4764  -16.6424
            35  N2b N    25.2968  -20.7959 #+
            36  O6a O    25.2743  -18.0169
            37  O3a O    25.2987  -22.1860 #-
            38  O3a O    26.8471  -19.6828
            39  C8x C    29.0380  -20.8078
            40  C8x C    29.0314  -22.2078
            41  C8x C    30.2404  -22.9136
            42  C8x C    31.4662  -22.2137
            43  C8x C    31.4728  -20.8137
BOND        47
            1    20  21 1
            2     8   9 2
            3    21  22 1
            4     9  10 1
            5    22  23 1
            6    10  11 1
            7    20  24 2
            8    11  12 2
            9    22  25 1
            10   12  13 1
            11    8  26 1
            12   13   8 1
            13   12  27 1
            14    4   7 1
            15   11  28 1
            16   10  14 1
            17   28  29 1
            18   29   5 1
            19    7   5 1
            20    1   4 1
            21    1   3 1
            22    1   2 1
            23    3  30 2
            24   30  31 1
            25   31  32 2
            26   32  33 1
            27   33  34 2
            28   34   3 1
            29   14  15 2
            30   15  16 1
            31   16  17 2
            32   17  18 1
            33   18  19 2
            34   19  14 1
            35   18  35 1
            36    5   6 1
            37   28  36 2
            38    9  20 1
            39   35  37 1
            40    6   4 1
            41   35  38 2
            42    2  39 2
            43   39  40 1
            44   40  41 2
            45   41  42 1
            46   42  43 2
            47    2  43 1

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