KEGG   DRUG: Prilocaine hydrochloride
Entry
D01243                      Drug                                   
Name
Prilocaine hydrochloride (USP);
Propitocaine hydrochloride (JAN);
Citanest (TN)
Product
  Generic
Formula
C13H20N2O. HCl
Exact mass
256.1342
Mol weight
256.7716
Structure
Simcomp
Class
Cardiovascular agent
 DG01575  Calcium channel blocker
  DG01573  Calcium channel T type blocker
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01673  Amide type local anesthetic
Remark
ATC code: N01BB04
Chemical structure group: DG00803
Product (DG00803): D01243<US>
Product (mixture): D04817<JP> D04818<US>
Efficacy
Anesthetic (local)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB04 Prilocaine
      D01243  Prilocaine hydrochloride (USP) <US>
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Prilocaine
   D01243  Prilocaine hydrochloride (USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01573  Calcium channel T type blocker
    DG00803  Prilocaine
     D01243  Prilocaine hydrochloride
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01673  Amide type local anesthetic
     DG00803  Prilocaine
      D01243  Prilocaine hydrochloride
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   D01243  Prilocaine hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN2A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN3A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN4A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN5A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN8A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN9A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN10A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN11A
     D01243  Prilocaine hydrochloride (USP) <US>
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01573  Calcium channel T type blocker
    DG00803  Prilocaine
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01673  Amide type local anesthetic
     DG00803  Prilocaine
Other DBs
CAS: 1786-81-8
PubChem: 7848306
ChEBI: 32053
LigandBox: D01243
NIKKAJI: J352.898G
LinkDB
KCF data

ATOM        17
            1   C8x C    16.3943  -16.8618
            2   C8x C    16.3943  -18.2644
            3   C8y C    17.6119  -18.9657
            4   C8y C    18.8224  -18.2644
            5   C8x C    18.8224  -16.8618
            6   C8x C    17.6119  -16.1605
            7   N1b N    20.0283  -18.9585
            8   C5a C    21.2396  -18.2572
            9   C1c C    22.4509  -18.9515
            10  N1b N    23.6622  -18.2503
            11  C1b C    24.8736  -18.9444
            12  C1b C    26.0849  -18.2431
            13  C1a C    27.2962  -18.9373
            14  C1a C    17.6685  -20.3682
            15  C1a C    22.4438  -20.3541
            16  O5a O    21.2325  -16.8546
            17  X   Cl   31.3854  -19.1015
BOND        16
            1     7   8 1
            2     1   2 2
            3     8   9 1
            4     2   3 1
            5     9  10 1
            6     3   4 2
            7    10  11 1
            8     4   5 1
            9    11  12 1
            10    5   6 2
            11   12  13 1
            12    6   1 1
            13    3  14 1
            14    9  15 1
            15    4   7 1
            16    8  16 2

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