KEGG   DRUG: ClobazamHelp
Entry
D01253                      Drug                                   

Name
Clobazam (JAN/USAN/INN);
Mystan (TN);
Onfi (TN)
Product
  Generic
CLOBAZAM (American Health Packaging), CLOBAZAM (Amneal Pharmaceuticals NY LLC), CLOBAZAM (Amneal Pharmaceuticals NY LLC), CLOBAZAM (Ascend Laboratories), CLOBAZAM (Bionpharma), CLOBAZAM (Bionpharma), CLOBAZAM (Breckenridge Pharmaceutical), CLOBAZAM (Cadila Healthcare Limited), CLOBAZAM (Camber Pharmaceuticals), CLOBAZAM (Lannett Company), CLOBAZAM (Lupin Pharmaceuticals), CLOBAZAM (Lupin Pharmaceuticals), CLOBAZAM (Micro Labs Limited), CLOBAZAM (Mylan Pharmaceuticals), CLOBAZAM (NorthStar RxLLC), CLOBAZAM (Sandoz), CLOBAZAM (Taro Pharmaceuticals U.S.A.), CLOBAZAM (Taro Pharmaceuticals U.S.A.), CLOBAZAM (Upsher-Smith Laboratories), CLOBAZAM (Upsher-Smith Laboratories), CLOBAZAM (VistaPharm), CLOBAZAM (West-Ward Pharmaceuticals Corp.), CLOBAZAM (West-Ward Pharmaceuticals Corp.), CLOBAZAM (Zydus Pharmaceuticals (USA))
Formula
C16H13ClN2O2
Exact mass
300.0666
Mol weight
300.7396
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01567  GABA-A receptor agonist
 DG01914  Anxiolytics, benzodiazepine derivatives
 DG02036  Antiepileptics, benzodiazepine derivatives
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1139
ATC code: N05BA09
Product: D01253<JP/US>
Efficacy
Anticonvulsant, Minor tranquilizer
  Disease
Lennox-Gastaut syndrome [DS:H01813]
Comment
Benzodiazepine derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C19 [HSA:1557]
Interaction
Drug interaction
Structure map
map07033  Anticonvulsants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA09 Clobazam
      D01253  Clobazam (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Benzodiazepines
    Clobazam
     D01253  Clobazam (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D01253  Clobazam (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D01253  Clobazam (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01253
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01253
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01253
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D01253
BRITE hierarchy
Other DBs
CAS: 22316-47-8
PubChem: 7848316
ChEBI: 31413
ChEMBL: CHEMBL70418
DrugBank: DB00349
LigandBox: D01253
NIKKAJI: J11.411A
LinkDB All DBs
KCF data Show

ATOM        21
            1   C5x C    20.8440  -16.6025
            2   C1x C    21.7290  -15.5177
            3   C5x C    21.4335  -14.1745
            4   N1y N    20.1974  -13.5636
            5   N1y N    19.4423  -16.6153
            6   C8y C    18.9128  -14.1417
            7   C8y C    18.5788  -15.4592
            8   C8x C    17.2356  -15.7546
            9   C8y C    16.2236  -14.8026
            10  C8x C    16.5605  -13.4152
            11  C8x C    17.9036  -13.1197
            12  X   Cl   14.8804  -15.0980
            13  O5x O    21.3522  -17.8843
            14  C8y C    18.7672  -17.7087
            15  C1a C    20.3245  -12.1676
            16  O5x O    22.5198  -13.3081
            17  C8x C    17.3603  -17.7403
            18  C8x C    16.6880  -18.9683
            19  C8x C    17.4154  -20.1645
            20  C8x C    18.8222  -20.1326
            21  C8x C    19.4945  -18.9046
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    6  11 2
            13    9  12 1
            14    1  13 2
            15    5  14 1
            16    4  15 1
            17    3  16 2
            18   14  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   14  21 1

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