KEGG   DRUG: Clobazam
Entry
D01253                      Drug                                   
Name
Clobazam (JAN/USAN/INN);
Mystan (TN);
Onfi (TN)
Product
  Generic
Formula
C16H13ClN2O2
Exact mass
300.0666
Mol weight
300.74
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01567  GABA-A receptor agonist
 DG01914  Anxiolytics, benzodiazepine derivatives
 DG03199  Antiepileptic agent
  DG02036  Benzodiazepine derivative, antiepileptic
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1139
ATC code: N05BA09
Product: D01253<JP/US>
Efficacy
Anticonvulsant, Minor tranquilizer
  Disease
Lennox-Gastaut syndrome [DS:H01813]
Comment
Benzodiazepine derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C19 [HSA:1557]
Interaction
Structure map
map07033  Anticonvulsants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA09 Clobazam
      D01253  Clobazam (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Benzodiazepines
    Clobazam
     D01253  Clobazam (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D01253  Clobazam (JAN/USAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01567  GABA-A receptor agonist
   D01253  Clobazam
  DG01914  Anxiolytics, benzodiazepine derivatives
   D01253  Clobazam
  DG03199  Antiepileptic agent
   DG02036  Benzodiazepine derivative, antiepileptic
    D01253  Clobazam
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   D01253  Clobazam
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D01253  Clobazam
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D01253  Clobazam
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D01253  Clobazam (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01253
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01253
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01253
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01253
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D01253
Narcotics and psychotropics in Japan [br08308.html]
 Psychotropics by Cabinet order Article 3 (78 substances)
  D01253
Other DBs
CAS: 22316-47-8
PubChem: 7848316
ChEBI: 31413
LigandBox: D01253
NIKKAJI: J11.411A
LinkDB
KCF data

ATOM        21
            1   C5x C    20.8440  -16.6025
            2   C1x C    21.7290  -15.5177
            3   C5x C    21.4335  -14.1745
            4   N1y N    20.1974  -13.5636
            5   N1y N    19.4423  -16.6153
            6   C8y C    18.9128  -14.1417
            7   C8y C    18.5788  -15.4592
            8   C8x C    17.2356  -15.7546
            9   C8y C    16.2236  -14.8026
            10  C8x C    16.5605  -13.4152
            11  C8x C    17.9036  -13.1197
            12  X   Cl   14.8804  -15.0980
            13  O5x O    21.3522  -17.8843
            14  C8y C    18.7672  -17.7087
            15  C1a C    20.3245  -12.1676
            16  O5x O    22.5198  -13.3081
            17  C8x C    17.3603  -17.7403
            18  C8x C    16.6880  -18.9683
            19  C8x C    17.4154  -20.1645
            20  C8x C    18.8222  -20.1326
            21  C8x C    19.4945  -18.9046
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    6  11 2
            13    9  12 1
            14    1  13 2
            15    5  14 1
            16    4  15 1
            17    3  16 2
            18   14  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   14  21 1

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