KEGG   DRUG: Clobazam
Entry
D01253                      Drug                                   
Name
Clobazam (JAN/USAN/INN);
Mystan (TN);
Onfi (TN)
Product
ONFI (Lundbeck Pharmaceuticals LLC), SYMPAZAN (Aquestive Therapeutics)
  Generic
CLOBAZAM (American Health Packaging), CLOBAZAM (Amneal Pharmaceuticals NY LLC), CLOBAZAM (Amneal Pharmaceuticals NY LLC), CLOBAZAM (Ascend Laboratories), CLOBAZAM (Ascend Laboratories), CLOBAZAM (Aurobindo Pharma Limited), CLOBAZAM (Bionpharma), CLOBAZAM (Breckenridge Pharmaceutical), CLOBAZAM (Camber Pharmaceuticals), CLOBAZAM (Camber Pharmaceuticals), CLOBAZAM (Chartwell RX), CLOBAZAM (Golden State Medical Supply), CLOBAZAM (Lupin Pharmaceuticals), CLOBAZAM (MSN LABORATORIES PRIVATE LIMITED), CLOBAZAM (Micro Labs Limited), CLOBAZAM (NorthStar RxLLC), CLOBAZAM (NorthStar RxLLC), CLOBAZAM (Novadoz Pharmaceuticals LLC), CLOBAZAM (Precision Dose), CLOBAZAM (Sandoz), CLOBAZAM (Taro Pharmaceuticals U.S.A.), CLOBAZAM (Taro Pharmaceuticals U.S.A.), CLOBAZAM (Upsher-Smith Laboratories), CLOBAZAM (VistaPharm)
Formula
C16H13ClN2O2
Exact mass
300.0666
Mol weight
300.74
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01567  GABA-A receptor agonist
 DG01914  Anxiolytics, benzodiazepine derivatives
 DG03199  Antiepileptic agent
  DG02036  Benzodiazepine derivative, antiepileptic
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1139
ATC code: N05BA09
Product: D01253<JP/US>
Efficacy
Anticonvulsant, Minor tranquilizer
  Disease
Lennox-Gastaut syndrome [DS:H01813]
Comment
Benzodiazepine derivative
Target
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C19 [HSA:1557]
Interaction
Structure map
map07033  Anticonvulsants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA09 Clobazam
      D01253  Clobazam (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Benzodiazepines
    Clobazam
     D01253  Clobazam (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D01253  Clobazam (JAN/USAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01567  GABA-A receptor agonist
   D01253  Clobazam
  DG01914  Anxiolytics, benzodiazepine derivatives
   D01253  Clobazam
  DG03199  Antiepileptic agent
   DG02036  Benzodiazepine derivative, antiepileptic
    D01253  Clobazam
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   D01253  Clobazam
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D01253  Clobazam
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D01253  Clobazam
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D01253  Clobazam (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01253
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01253
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01253
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01253
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D01253
Narcotics and psychotropics in Japan [br08308.html]
 Psychotropics by Cabinet order Article 3 (78 substances)
  D01253
Other DBs
CAS: 22316-47-8
PubChem: 7848316
ChEBI: 31413
LigandBox: D01253
NIKKAJI: J11.411A
LinkDB
KCF data

ATOM        21
            1   C5x C    20.8440  -16.6025
            2   C1x C    21.7290  -15.5177
            3   C5x C    21.4335  -14.1745
            4   N1y N    20.1974  -13.5636
            5   N1y N    19.4423  -16.6153
            6   C8y C    18.9128  -14.1417
            7   C8y C    18.5788  -15.4592
            8   C8x C    17.2356  -15.7546
            9   C8y C    16.2236  -14.8026
            10  C8x C    16.5605  -13.4152
            11  C8x C    17.9036  -13.1197
            12  X   Cl   14.8804  -15.0980
            13  O5x O    21.3522  -17.8843
            14  C8y C    18.7672  -17.7087
            15  C1a C    20.3245  -12.1676
            16  O5x O    22.5198  -13.3081
            17  C8x C    17.3603  -17.7403
            18  C8x C    16.6880  -18.9683
            19  C8x C    17.4154  -20.1645
            20  C8x C    18.8222  -20.1326
            21  C8x C    19.4945  -18.9046
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    6  11 2
            13    9  12 1
            14    1  13 2
            15    5  14 1
            16    4  15 1
            17    3  16 2
            18   14  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   14  21 1

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