KEGG   DRUG: Droxidopa
Entry
D01277                      Drug                                   
Name
Droxidopa (JP18/USAN/INN);
Dops (TN);
Northera (TN)
Product
NORTHERA (Lundbeck Pharmaceuticals LLC)
  Generic
DROXIDOPA (Ajanta Pharma USA), DROXIDOPA (Ascend Laboratories), DROXIDOPA (Aurobindo Pharma Limited), DROXIDOPA (Bionpharma), DROXIDOPA (Camber Pharmaceuticals), DROXIDOPA (CivicaScript LLC), DROXIDOPA (Golden State Medical Supply), DROXIDOPA (Lupin Pharmaceuticals), DROXIDOPA (MAJOR PHARMACEUTICALS), DROXIDOPA (MSN LABORATORIES PRIVATE LIMITED), DROXIDOPA (Novadoz Pharmaceuticals LLC), DROXIDOPA (ScieGen Pharmaceuticals), DROXIDOPA (Slate Run Pharmaceuticals), DROXIDOPA (Sun Pharmaceutical Industries), DROXIDOPA (Upsher-Smith Laboratories), DROXIDOPA (Zydus Lifesciences Limited), DROXIDOPA (Zydus Pharmaceuticals USA)
Formula
C9H11NO5
Exact mass
213.0637
Mol weight
213.19
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01967  Antiparkinson agent
Remark
Therapeutic category: 1169
ATC code: C01CA27
Product: D01277<JP/US>
Efficacy
Antiparkinsonian, Replenisher (noradrenalin)
  Disease
Parkinson disease [DS:H00057]
Multiple system atrophy [DS:H01614]
Dopamine beta-hydroxylase deficiency [DS:H01005]
Comment
precursor of Norepinephrine [DR:D00076]
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
Interaction
Structure map
map07057  Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA27 Droxidopa
      D01277  Droxidopa (JP18/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Droxidopa
    D01277  Droxidopa (JP18/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1169  Others
     D01277  Droxidopa (JP18/USAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01967  Antiparkinson agent
   D01277  Droxidopa
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01967  Antiparkinson agent
   D01277  Droxidopa
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D01277  Droxidopa (JP18/USAN/INN) <JP/US>
    ADRA2
     D01277  Droxidopa (JP18/USAN/INN) <JP/US>
    ADRB
     D01277  Droxidopa (JP18/USAN/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01277  Droxidopa
  D01277  Droxidopa capsules
  D01277  Droxidopa fine granules
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01277
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01277
Other DBs
CAS: 23651-95-8
PubChem: 7848340
ChEBI: 31524
LigandBox: D01277
NIKKAJI: J22.085J
LinkDB
KCF data

ATOM        15
            1   C8y C     5.1800   -5.1100
            2   C8y C     5.1800   -6.5100
            3   C8x C     6.4400   -7.2100
            4   C8x C     7.6300   -6.5100
            5   C8y C     7.6300   -5.1100
            6   C8x C     6.4400   -4.4100
            7   O1a O     3.9900   -7.2100
            8   C1c C     8.8200   -4.4100
            9   C1c C    10.0100   -5.1100
            10  C6a C    11.2700   -4.4100
            11  O6a O    12.4600   -5.1100
            12  O6a O    11.2700   -3.0100
            13  O1a O     8.8200   -3.0100
            14  N1a N    10.0100   -6.5100
            15  O1a O     3.9734   -4.4000
BOND        15
            1     1   2 2
            2     2   3 1
            3     5   8 1
            4     3   4 2
            5     8   9 1
            6     4   5 1
            7     9  10 1
            8     5   6 2
            9    10  11 1
            10    6   1 1
            11   10  12 2
            12    8  13 1 #Up
            13    2   7 1
            14    9  14 1 #Up
            15    1  15 1

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