| Entry |
|
|---|
| Name |
Droxidopa (JP17/INN);
Dops (TN);
Northera (TN)
|
|---|
| Product |
|
|---|
| Formula |
C9H11NO5
|
|---|
| Exact mass |
213.0637
|
|---|
| Mol weight |
213.1873
|
|---|
| Structure |
   |
|---|
| Simcomp |
 |
|---|
| Class |
Neuropsychiatric agent
DG01967 Antiparkinson agent
|
|---|
| Remark |
| Therapeutic category: | 1169 |
|
|---|
| Efficacy |
Antiparkinsonian, Replenisher (noradrenalin) |
|---|
| Disease |
Parkinson disease [DS: H00057] Multiple system atrophy [DS: H01614] Dopamine beta-hydroxylase deficiency [DS: H01005] |
|---|
| Comment |
precursor of Norepinephrine [DR: D00076]
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
C01CA Adrenergic and dopaminergic agents
C01CA27 Droxidopa
D01277 Droxidopa (JP17/INN) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Alpha-adrenergic Agonists
Droxidopa
D01277 Droxidopa (JP17/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
116 Antiparkinsonian agents
1169 Others
D01277 Droxidopa (JP17/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D01277 Droxidopa (JP17/INN) <JP/US>
ADRA2
D01277 Droxidopa (JP17/INN) <JP/US>
ADRB
D01277 Droxidopa (JP17/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01277 Droxidopa
D01277 Droxidopa capsules
D01277 Droxidopa fine granules
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D01277
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D01277
 |
|---|
| Other DBs |
|
|---|
| LinkDB |
 |
|---|
| KCF data |
ATOM 15
1 C8y C 5.1800 -5.1100
2 C8y C 5.1800 -6.5100
3 C8x C 6.4400 -7.2100
4 C8x C 7.6300 -6.5100
5 C8y C 7.6300 -5.1100
6 C8x C 6.4400 -4.4100
7 O1a O 3.9900 -7.2100
8 C1c C 8.8200 -4.4100
9 C1c C 10.0100 -5.1100
10 C6a C 11.2700 -4.4100
11 O6a O 12.4600 -5.1100
12 O6a O 11.2700 -3.0100
13 O1a O 8.8200 -3.0100
14 N1a N 10.0100 -6.5100
15 O1a O 3.9734 -4.4000
BOND 15
1 1 2 2
2 2 3 1
3 5 8 1
4 3 4 2
5 8 9 1
6 4 5 1
7 9 10 1
8 5 6 2
9 10 11 1
10 6 1 1
11 10 12 2
12 8 13 1 #Up
13 2 7 1
14 9 14 1 #Up
15 1 15 1
|
|---|
