KEGG   DRUG: Doxifluridine
Entry
D01309                      Drug                                   
Name
Doxifluridine (JP18/INN);
Furtulon (TN)
Formula
C9H11FN2O5
Exact mass
246.0652
Mol weight
246.1924
Structure
Simcomp
Class
Antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01935  Fluoropyrimidine antineoplastic
Remark
Same as: C12739
Therapeutic category: 4223
Product: D01309<JP>
Efficacy
Antineoplastic, Antimetabolite
Comment
Active form of prodrug: Fluorouracil [DR:D00584]
Target
TYMS [HSA:7298] [KO:K00560]
  Pathway
hsa00240  Pyrimidine metabolism
hsa00670  One carbon pool by folate
Interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
Other map
map00983  Drug metabolism - other enzymes
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   422  Antimetabolites
    4223  Fluorouracils
     D01309  Doxifluridine (JP18/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG02018  Antimetabolite
   DG01958  Nucleic acid derivative, antineoplastic
    DG01935  Fluoropyrimidine antineoplastic
     D01309  Doxifluridine
Drug classes [BR:br08332]
 Antineoplastic
  DG02018  Antimetabolite
   D01309  Doxifluridine
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    TYMS
     D01309  Doxifluridine (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01309  Doxifluridine
  D01309  Doxifluridine capsules
Prodrugs [br08324.html]
 D01309
Other DBs
CAS: 3094-09-5
PubChem: 7848372
ChEBI: 31521
LigandBox: D01309
NIKKAJI: J7.679A
LinkDB
KCF data

ATOM        17
            1   C1y C    22.8703  -17.4990
            2   N4y N    24.5207  -16.9314
            3   O2x O    21.7034  -16.6238
            4   C1y C    22.4328  -18.8118
            5   C8y C    25.7785  -17.6293
            6   C8x C    24.4865  -15.5558
            7   C1y C    20.6094  -17.4261
            8   C1y C    21.0470  -18.8118
            9   O1a O    23.2350  -19.9058
            10  N4x N    26.9723  -16.9258
            11  O5x O    25.7354  -18.9679
            12  C8y C    25.7504  -14.8522
            13  O1a O    20.2448  -19.9058
            14  C8y C    26.9711  -15.4873
            15  O5x O    28.1650  -14.7838
            16  C1a C    19.2967  -17.0614
            17  X   F    25.7492  -13.4138
BOND        18
            1     1   3 1
            2     1   4 1
            3     2   5 1
            4     2   6 1
            5     3   7 1
            6     4   8 1
            7     4   9 1 #Down
            8     5  10 1
            9     5  11 2
            10    6  12 2
            11    8  13 1 #Down
            12   10  14 1
            13   14  15 2
            14    7   8 1
            15   12  14 1
            16    7  16 1 #Up
            17    1   2 1 #Up
            18   12  17 1

» Japanese version   » Back

KEGG   COMPOUND: C12739
Entry
C12739                      Compound                               
Name
5'-Deoxy-5-fluorouridine;
Doxifluridine
Formula
C9H11FN2O5
Exact mass
246.0652
Mol weight
246.1924
Structure
Remark
Same as: D01309
Reaction
R08221 R08222
Pathway
map00983  Drug metabolism - other enzymes
Enzyme
2.4.2.4         3.5.4.5
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   422  Antimetabolites
    4223  Fluorouracils
     D01309  Doxifluridine (JP18/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG02018  Antimetabolite
   DG01958  Nucleic acid derivative, antineoplastic
    DG01935  Fluoropyrimidine antineoplastic
     D01309  Doxifluridine
Drug classes [BR:br08332]
 Antineoplastic
  DG02018  Antimetabolite
   D01309  Doxifluridine
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    TYMS
     D01309  Doxifluridine (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01309  Doxifluridine
  D01309  Doxifluridine capsules
Prodrugs [br08324.html]
 D01309
Prodrugs [br08324.html]
 C12739
Other DBs
CAS: 3094-09-5
PubChem: 583128
ChEBI: 31521
NIKKAJI: J7.679A
LinkDB
KCF data

ATOM        17
            1   C1y C    23.0300  -17.7800
            2   N4y N    24.6400  -17.2200
            3   O2x O    21.9100  -16.9400
            4   C1y C    22.6100  -19.1100
            5   C8y C    25.9000  -17.9200
            6   C8x C    24.6400  -15.8900
            7   C1y C    20.7900  -17.7100
            8   C1y C    21.2100  -19.1100
            9   O1a O    23.3800  -20.1600
            10  N4x N    27.0900  -17.2200
            11  O5x O    25.9000  -19.2500
            12  C8y C    25.9000  -15.1900
            13  O1a O    20.4400  -20.1600
            14  C8y C    27.0900  -15.8200
            15  O5x O    28.2800  -15.1200
            16  C1a C    19.5300  -17.3600
            17  X   F    25.9000  -13.7200
BOND        18
            1     1   3 1
            2     1   4 1
            3     2   5 1
            4     2   6 1
            5     3   7 1
            6     4   8 1
            7     4   9 1 #Down
            8     5  10 1
            9     5  11 2
            10    6  12 2
            11    8  13 1 #Down
            12   10  14 1
            13   14  15 2
            14    7   8 1
            15   12  14 1
            16    7  16 1 #Up
            17    1   2 1 #Up
            18   12  17 1

» Japanese version

DBGET integrated database retrieval system