KEGG   DRUG: Formoterol fumarate
Entry
D01373                      Drug                                   
Name
Formoterol fumarate (USP);
Foradil (TN)
Product
  Generic
FORMOTEROL FUMARATE (Alembic Pharmaceuticals), FORMOTEROL FUMARATE (Bryant Ranch Prepack), FORMOTEROL FUMARATE (Bryant Ranch Prepack), FORMOTEROL FUMARATE (Lupin Pharmaceuticals), FORMOTEROL FUMARATE (Teva Pharmaceuticals USA)
Formula
(C19H24N2O4)2. C4H4O4
Exact mass
804.3582
Mol weight
804.8819
Structure
Simcomp
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
ATC code: R03AC13 R03CC15
Chemical structure group: DG01052
Product (DG01052): D01373<US> D05277<JP/US>
Product (mixture): D10295<US> D11036<JP/US> D11584<JP/US> D11857<US>
Efficacy
Bronchodilator, beta2-Adrenergic receptor agonist
  Disease
Asthma [DS:H00079]
Chronic obstructive pulmonary disease [DS:H01714]
Comment
Phenethylamine derivative
Target
ADRB2 [HSA:154] [KO:K04142]
  Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AC Selective beta-2-adrenoreceptor agonists
     R03AC13 Formoterol
      D01373  Formoterol fumarate (USP) <US>
   R03C ADRENERGICS FOR SYSTEMIC USE
    R03CC Selective beta-2-adrenoreceptor agonists
     R03CC15 Formoterol
      D01373  Formoterol fumarate (USP) <US>
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01455  beta-Adrenergic receptor agonist
    DG01452  beta2-Adrenergic receptor agonist
     DG01052  Formoterol
      D01373  Formoterol fumarate
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG01052  Formoterol
    D01373  Formoterol fumarate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB2
     D01373  Formoterol fumarate (USP) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01373
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01373
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01373
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01455  beta-Adrenergic receptor agonist
    DG01452  beta2-Adrenergic receptor agonist
     DG01052  Formoterol
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG01052  Formoterol
Other DBs
CAS: 43229-80-7
PubChem: 7848436
ChEBI: 31633
LigandBox: D01373
NIKKAJI: J364.822B
LinkDB
KCF data

ATOM        58
            1   C6a C    42.5268  -20.4767
            2   C2b C    43.7345  -21.1769
            3   O6a O    41.3191  -21.1769
            4   O6a O    42.5268  -19.0825
            5   C2b C    44.9479  -20.4767
            6   C6a C    46.1556  -21.1769
            7   O6a O    47.3633  -20.4767
            8   O6a O    46.1556  -22.5713
            9   C8y C    24.5700  -21.2100
            10  C8x C    23.3800  -21.9100
            11  C8x C    24.5700  -19.8100
            12  C1c C    25.7600  -21.9100
            13  C8y C    22.1200  -21.2100
            14  C8x C    23.3800  -19.1100
            15  C1b C    27.0200  -21.2100
            16  O1a O    25.7600  -23.3100
            17  C8y C    22.1200  -19.8100
            18  N1b N    20.9300  -21.9100
            19  N1b N    28.2100  -21.9100
            20  O1a O    20.9300  -19.1100
            21  C4a C    19.7400  -21.2100
            22  C1c C    29.4000  -21.2100
            23  O4a O    18.4800  -21.9100
            24  C1b C    30.5900  -21.9100
            25  C1a C    29.4000  -19.8100
            26  C8y C    31.8500  -21.2100
            27  C8x C    31.8500  -19.8100
            28  C8x C    33.0400  -21.9100
            29  C8x C    33.0400  -19.1100
            30  C8x C    34.2300  -21.2100
            31  C8y C    34.2300  -19.8100
            32  O2a O    35.4900  -19.0400
            33  C1a C    36.6800  -19.7400
            34  C8y C    24.5700  -21.2100
            35  C8x C    23.3800  -21.9100
            36  C8y C    22.1200  -21.2100
            37  C8y C    22.1200  -19.8100
            38  O1a O    20.9300  -19.1100
            39  C8x C    23.3800  -19.1100
            40  C8x C    24.5700  -19.8100
            41  N1b N    20.9300  -21.9100
            42  C4a C    19.7400  -21.2100
            43  O4a O    18.4800  -21.9100
            44  C1c C    25.7600  -21.9100
            45  C1b C    27.0200  -21.2100
            46  N1b N    28.2100  -21.9100
            47  C1c C    29.4000  -21.2100
            48  C1b C    30.5900  -21.9100
            49  C8y C    31.8500  -21.2100
            50  C8x C    31.8500  -19.8100
            51  C8x C    33.0400  -19.1100
            52  C8y C    34.2300  -19.8100
            53  O2a O    35.4900  -19.0400
            54  C1a C    36.6800  -19.7400
            55  C8x C    34.2300  -21.2100
            56  C8x C    33.0400  -21.9100
            57  C1a C    29.4000  -19.8100
            58  O1a O    25.7600  -23.3100
BOND        59
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     5   6 1
            6     6   7 1
            7     6   8 2
            8     9  10 2
            9     9  11 1
            10    9  12 1
            11   10  13 1
            12   11  14 2
            13   12  15 1
            14   12  16 1
            15   13  17 2
            16   13  18 1
            17   15  19 1
            18   17  20 1
            19   18  21 1
            20   19  22 1
            21   21  23 2
            22   22  24 1
            23   22  25 1
            24   24  26 1
            25   26  27 2
            26   26  28 1
            27   27  29 1
            28   28  30 2
            29   29  31 2
            30   31  32 1
            31   32  33 1
            32   14  17 1
            33   30  31 1
            34   34  35 2
            35   34  40 1
            36   34  44 1
            37   35  36 1
            38   40  39 2
            39   44  45 1
            40   44  58 1
            41   36  37 2
            42   36  41 1
            43   45  46 1
            44   37  38 1
            45   41  42 1
            46   46  47 1
            47   42  43 2
            48   47  48 1
            49   47  57 1
            50   48  49 1
            51   49  50 2
            52   49  56 1
            53   50  51 1
            54   56  55 2
            55   51  52 2
            56   52  53 1
            57   53  54 1
            58   39  37 1
            59   55  52 1
BRACKET     1    17.2900  -24.0100   17.2900  -17.6400
            1    38.8500  -17.6400   38.8500  -24.0100
            1  2
 ORIGINAL  1    9  10  13  17  20  14  11  18  21  23  12  15  19  22  24  26
            1   27  29  31  32  33  30  28  25  16
 REPEAT    1   34  35  36  37  38  39  40  41  42  43  44  45  46  47  48  49
            1   50  51  52  53  54  55  56  57  58

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