KEGG   DRUG: Ephedrine hydrochlorideHelp
Entry
D01386                      Drug                                   

Name
Ephedrine hydrochloride (JP17/USP);
Ephedrine hydrochloride (TN)
Formula
C10H15NO. HCl
Exact mass
201.092
Mol weight
201.6931
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01702  Phenethylamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01451  beta1-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
Remark
Therapeutic category: 2118 2221
ATC code: C01CA26 R01AA03 R01AB05 R03CA02 S01FB02
Chemical structure group: DG00227
Product (DG00227): D01386<JP> D04018<US>
Product (mixture): D04338<JP> D04299<JP> D04307<JP>
Efficacy
Antitussive, Bronchodilator, Adrenergic receptor agonist
Comment
Phenethylamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA26 Ephedrine
      D01386  Ephedrine hydrochloride (JP17/USP) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA03 Ephedrine
      D01386  Ephedrine hydrochloride (JP17/USP) <JP>
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB05 Ephedrine
      D01386  Ephedrine hydrochloride (JP17/USP) <JP>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03C ADRENERGICS FOR SYSTEMIC USE
    R03CA Alpha- and beta-adrenoreceptor agonists
     R03CA02 Ephedrine
      D01386  Ephedrine hydrochloride (JP17/USP) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FB Sympathomimetics excl. antiglaucoma preparations
     S01FB02 Ephedrine
      D01386  Ephedrine hydrochloride (JP17/USP) <JP>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Sympathomimetic
   Ephedrine
    D01386  Ephedrine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   211  Cardiotonics
    2118  Alkaloids
     D01386  Ephedrine hydrochloride (JP17/USP)
  22  Respiratory organ agents
   222  Antitussives
    2221  Ephedrines and Ephedra herbs
     D01386  Ephedrine hydrochloride (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Ephedrine
    D01386  Ephedrine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D01386  Ephedrine hydrochloride (JP17/USP) <JP>
    ADRA2
     D01386  Ephedrine hydrochloride (JP17/USP) <JP>
    ADRB
     D01386  Ephedrine hydrochloride (JP17/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01386  Ephedrine hydrochloride
  D01386  Ephedrine hydrochloride tablets
  D01386  10% Ephedrine hydrochloride powder
  D01386  Ephedrine hydrochloride injection
Drug classes of therapeutic agents [br08360.html]
 Respiratory agents
  D01386
Rx-to-OTC switch list in the USA [br08315.html]
 D01386
BRITE hierarchy
Other DBs
CAS: 50-98-6
PubChem: 7848449
ChEBI: 31541
ChEMBL: CHEMBL2146102
LigandBox: D01386
NIKKAJI: J231.451G
LinkDB All DBs
KCF data Show

ATOM        13
            1   C8x C    17.0325  -17.0009
            2   C8x C    17.0325  -18.4031
            3   C8x C    18.2497  -19.1041
            4   C8x C    19.4598  -18.4031
            5   C8y C    19.4598  -17.0009
            6   C8x C    18.2497  -16.2999
            7   C1c C    20.6653  -16.2999
            8   C1c C    21.8762  -16.9938
            9   N1b N    23.0872  -16.2927
            10  C1a C    24.2981  -16.9867
            11  O1a O    20.6609  -14.8977
            12  C1a C    21.8793  -18.3959
            13  X   Cl   29.1200  -17.5000
BOND        12
            1     6   1 1
            2     5   7 1
            3     1   2 2
            4     7   8 1
            5     2   3 1
            6     8   9 1
            7     3   4 2
            8     9  10 1
            9     4   5 1
            10    7  11 1 #Up
            11    5   6 2
            12    8  12 1 #Up

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