| Entry |
|
|---|
| Name |
Aranidipine (JAN/INN);
Sapresta (TN) |
|---|
| Formula |
C19H20N2O7
|
|---|
| Exact mass |
388.1271
|
|---|
| Mol weight |
388.37
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG01573 Calcium channel T type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Efficacy |
Antihypertensive, Calcium channel blocker |
|---|
| Comment |
Dihydropyridine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
D01562 Aranidipine
DG01573 Calcium channel T type blocker
D01562 Aranidipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
D01562 Aranidipine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D01562 Aranidipine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D01562 Aranidipine (JAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01562
|
|---|
| Other DBs |
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|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 28
1 C1y C 22.3513 -16.1389
2 C8y C 22.3395 -18.5314
3 C2y C 21.2049 -15.4862
4 C2y C 23.4976 -15.4862
5 C8y C 21.1874 -19.1958
6 C8x C 23.4800 -19.1958
7 C2y C 21.2049 -14.1634
8 C7a C 20.0644 -16.1389
9 C2y C 23.4976 -14.1634
10 C7a C 24.6382 -16.1389
11 C8x C 21.1874 -20.5067
12 N2b N 20.0586 -18.5314 #+
13 C8x C 23.4800 -20.5067
14 N1x N 22.3513 -13.5050
15 C1a C 20.0644 -13.5050
16 O7a O 18.9240 -15.4862
17 O6a O 20.0703 -17.3616
18 C1a C 24.6382 -13.5050
19 O7a O 25.7727 -15.4862
20 O6a O 24.6382 -17.4615
21 C8x C 22.3395 -21.1769
22 O3a O 21.5634 -17.5379
23 O3a O 18.1950 -19.7719 #-
24 C1b C 17.7834 -16.1389
25 C1a C 26.9133 -16.1389
26 C5a C 16.6480 -15.4775
27 C1a C 15.5075 -16.1302
28 O5a O 16.6531 -14.1634
BOND 29
1 1 4 1
2 2 5 1
3 2 6 2
4 3 7 2
5 3 8 1
6 4 9 2
7 4 10 1
8 5 11 2
9 5 12 1
10 6 13 1
11 7 14 1
12 7 15 1
13 8 16 1
14 8 17 2
15 9 18 1
16 10 19 1
17 10 20 2
18 11 21 1
19 12 22 2
20 12 23 1
21 16 24 1
22 19 25 1
23 9 14 1
24 13 21 2
25 24 26 1
26 1 2 1
27 26 27 1
28 1 3 1
29 26 28 2
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|---|
