KEGG   DRUG: AranidipineHelp
Entry
D01562                      Drug                                   

Name
Aranidipine (JAN/INN);
Sapresta (TN)
Formula
C19H20N2O7
Exact mass
388.1271
Mol weight
388.3713
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01928  Dihydropyridine calcium channel blocker
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
  DG01573  Calcium channel T type blocker
Enzyme substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 2149
Product: D01562<JP>
Efficacy
Antihypertensive, Calcium channel blocker
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07036  Calcium channel blocking drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01562  Aranidipine (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-L
     D01562  Aranidipine (JAN/INN) <JP>
Drug classes of therapeutic agents [br08360.html]
 Cardiovascular agents
  D01562
BRITE hierarchy
Other DBs
CAS: 86780-90-7
PubChem: 7848625
ChEBI: 31232
ChEMBL: CHEMBL2104030
LigandBox: D01562
NIKKAJI: J353.474J J511.078E
LinkDB All DBs
KCF data Show

ATOM        28
            1   C1y C    22.3513  -16.1389
            2   C8y C    22.3395  -18.5314
            3   C2y C    21.2049  -15.4862
            4   C2y C    23.4976  -15.4862
            5   C8y C    21.1874  -19.1958
            6   C8x C    23.4800  -19.1958
            7   C2y C    21.2049  -14.1634
            8   C7a C    20.0644  -16.1389
            9   C2y C    23.4976  -14.1634
            10  C7a C    24.6382  -16.1389
            11  C8x C    21.1874  -20.5067
            12  N2b N    20.0586  -18.5314 #+
            13  C8x C    23.4800  -20.5067
            14  N1x N    22.3513  -13.5050
            15  C1a C    20.0644  -13.5050
            16  O7a O    18.9240  -15.4862
            17  O6a O    20.0703  -17.3616
            18  C1a C    24.6382  -13.5050
            19  O7a O    25.7727  -15.4862
            20  O6a O    24.6382  -17.4615
            21  C8x C    22.3395  -21.1769
            22  O3a O    21.5634  -17.5379
            23  O3a O    18.1950  -19.7719 #-
            24  C1b C    17.7834  -16.1389
            25  C1a C    26.9133  -16.1389
            26  C5a C    16.6480  -15.4775
            27  C1a C    15.5075  -16.1302
            28  O5a O    16.6531  -14.1634
BOND        29
            1     1   4 1
            2     2   5 1
            3     2   6 2
            4     3   7 2
            5     3   8 1
            6     4   9 2
            7     4  10 1
            8     5  11 2
            9     5  12 1
            10    6  13 1
            11    7  14 1
            12    7  15 1
            13    8  16 1
            14    8  17 2
            15    9  18 1
            16   10  19 1
            17   10  20 2
            18   11  21 1
            19   12  22 2
            20   12  23 1
            21   16  24 1
            22   19  25 1
            23    9  14 1
            24   13  21 2
            25   24  26 1
            26    1   2 1
            27   26  27 1
            28    1   3 1
            29   26  28 2

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