KEGG   DRUG: Fluticasone propionateHelp
Entry
D01708                      Drug                                   

Name
Fluticasone propionate (JAN/USAN);
Cutivate (TN);
Flonase (TN);
Flovent (TN)
Product
  Generic
FLUTICASONE (Direct RX), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (Aidarex Pharmaceuticals LLC), FLUTICASONE PROPIONATE (Almus), FLUTICASONE PROPIONATE (Apotex Corp.), FLUTICASONE PROPIONATE (Apotex Corp.), FLUTICASONE PROPIONATE (Blenheim Pharmacal), FLUTICASONE PROPIONATE (DIRECT RX), FLUTICASONE PROPIONATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUTICASONE PROPIONATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUTICASONE PROPIONATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUTICASONE PROPIONATE (G&W Laboratories), FLUTICASONE PROPIONATE (G&W Laboratories), FLUTICASONE PROPIONATE (Glenmark Pharmaceuticals), FLUTICASONE PROPIONATE (Golden State Medical Supply), FLUTICASONE PROPIONATE (H J Harkins Company), FLUTICASONE PROPIONATE (Hi-Tech Pharmacal), FLUTICASONE PROPIONATE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), FLUTICASONE (Lake Erie Medical DBA Quality Care Products LLC), FLUTICASONE PROPIONATE (Lake Erie Medical DBA Quality Care Products LLC), FLUTICASONE (Medsource Pharmaceuticals), FLUTICASONE (Morton Grove Pharmaceuticals), FLUTICASONE (NuCare Pharmaceuticals), FLUTICASONE PROPIONATE (NuCare Pharmaceuticals), FLUTICASONE PROPIONATE (Perrigo New York), FLUTICASONE PROPIONATE (Perrigo New York), FLUTICASONE PROPIONATE (Perrigo New York), FLUTICASONE PROPIONATE (Preferred Pharmaceuticals), FLUTICASONE PROPIONATE (Preferred Pharmaceuticals), FLUTICASONE PROPIONATE (Proficient Rx LP), FLUTICASONE PROPIONATE (Proficient Rx LP), FLUTICASONE PROPIONATE (Proficient Rx LP), FLUTICASONE PROPIONATE (Proficient Rx LP), TICANASE (PureTek Corporation), FLUTICASONE PROPIONATE (REMEDYREPACK), FLUTICASONE PROPIONATE (REMEDYREPACK), FLUTICASONE PROPIONATE (RPK Pharmaceuticals), FLUTICASONE PROPIONATE (RPK Pharmaceuticals), FLUTICASONE PROPIONATE (Rebel Distributors Corp), TICASPRAY (Shoreline Pharmaceuticals), FLUTICASONE PROPIONATE (Taro Pharmaceuticals U.S.A.), FLUTICASONE (Unit Dose Services), FLUTICASONE (Unit Dose Services), FLUTICASONE PROPIONATE (Unit Dose Services), FLUTICASONE PROPIONATE (West-Ward Pharmaceuticals Corp.)
Formula
C25H31F3O5S
Exact mass
500.1844
Mol weight
500.5709
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 1329 2290
ATC code: D07AC17 R01AD08 R03BA05
Chemical structure group: DG00420
Product (DG00420): D01708<JP/US> D06315<JP/US>
Product (mixture): D08699<JP/US> D10506<JP>
Efficacy
Antiasthmatic, Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Asthma [DS:H00079]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC17 Fluticasone
      D01708  Fluticasone propionate (JAN/USAN) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD08 Fluticasone
      D01708  Fluticasone propionate (JAN/USAN) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA05 Fluticasone
      D01708  Fluticasone propionate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Fluticasone
   D01708  Fluticasone propionate (JAN/USAN)
 Respiratory Tract/Pulmonary Agents
  Anti-inflammatories, Inhaled Corticosteroids
   Fluticasone
    D01708  Fluticasone propionate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   132  Otic and nasal agents
    1329  Others
     D01708  Fluticasone propionate (JAN/USAN)
 2  Agents affecting individual organs
  22  Respiratory organ agents
   229  Miscellaneous
    2290  Miscellaneous
     D01708  Fluticasone propionate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01708  Fluticasone propionate (JAN/USAN) <JP/US>
Topical steroids potency [br08317.html]
 Classification in the USA
  D01708
Rx-to-OTC switch list in the USA [br08315.html]
 D01708
BRITE hierarchy
Other DBs
CAS: 80474-14-2
PubChem: 7848771
ChEBI: 31441
ChEMBL: CHEMBL1473 CHEMBL3182902
DrugBank: DB00588
LigandBox: D01708
NIKKAJI: J457.058H
LinkDB All DBs
KCF data Show

ATOM        34
            1   C2x C    19.6000  -28.4200
            2   C5x C    19.6000  -29.7500
            3   C2x C    20.7900  -30.4500
            4   C2y C    21.9100  -29.7500
            5   C1z C    21.9100  -28.4200
            6   C2x C    20.7900  -27.7200
            7   C1y C    23.1000  -30.4500
            8   C1x C    24.3600  -29.7500
            9   C1y C    24.3600  -28.4200
            10  C1z C    23.1000  -27.7200
            11  C1y C    25.4100  -27.7200
            12  C1z C    25.4100  -26.3900
            13  C1x C    24.3600  -25.6900
            14  C1y C    23.1000  -26.3900
            15  C1x C    27.7200  -27.7200
            16  C1y C    27.7200  -26.3900
            17  C1z C    26.5300  -25.6900
            18  O5x O    18.4100  -30.4500
            19  C1a C    21.9100  -27.0200
            20  X   F    23.1000  -29.0500
            21  O1a O    21.9100  -25.6900
            22  C1a C    25.4100  -24.9900
            23  O7a O    27.9300  -24.7800
            24  C1a C    29.1200  -26.3900
            25  X   F    23.1000  -31.8500
            26  C5a C    26.5300  -24.2900
            27  O5a O    27.7900  -23.5900
            28  S2a S    25.2700  -23.5900
            29  C1b C    24.0800  -24.2900
            30  X   F    22.8900  -23.5900
            31  C7a C    29.1200  -24.0800
            32  C1b C    30.3100  -24.7800
            33  C1a C    31.5000  -24.0800
            34  O6a O    29.1200  -22.6800
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   10  20 1 #Down
            24   14  21 1 #Up
            25   12  22 1 #Up
            26   17  23 1 #Down
            27   16  24 1 #Down
            28    7  25 1 #Down
            29   17  26 1 #Up
            30   26  27 2
            31   26  28 1
            32   28  29 1
            33   29  30 1
            34   31  32 1
            35   31  23 1
            36   32  33 1
            37   31  34 2

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