KEGG   DRUG: Fluticasone furoateHelp
Entry
D06315                      Drug                                   

Name
Fluticasone furoate (JAN/USAN/INN);
Veramyst (TN)
Product
Formula
C27H29F3O6S
Exact mass
538.1637
Mol weight
538.5758
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 1329 2290
ATC code: D07AC17 R01AD08 R01AD12 R03BA05 R03BA09
Chemical structure group: DG00420
Product (DG00420): D01708<JP/US> D06315<JP/US>
Product (mixture): D10501<JP/US> D11035<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Allergic rhinitis [DS:H01360]
Asthma [DS:H00079]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC17 Fluticasone
      D06315  Fluticasone furoate (JAN/USAN/INN) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD08 Fluticasone
      D06315  Fluticasone furoate (JAN/USAN/INN) <JP/US>
     R01AD12 Fluticasone furoate
      D06315  Fluticasone furoate (JAN/USAN/INN) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA05 Fluticasone
      D06315  Fluticasone furoate (JAN/USAN/INN) <JP/US>
     R03BA09 Fluticasone furoate
      D06315  Fluticasone furoate (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Fluticasone
   D06315  Fluticasone furoate (JAN/USAN/INN)
 Respiratory Tract/Pulmonary Agents
  Anti-inflammatories, Inhaled Corticosteroids
   Fluticasone
    D06315  Fluticasone furoate (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   132  Otic and nasal agents
    1329  Others
     D06315  Fluticasone furoate (JAN/USAN/INN)
 2  Agents affecting individual organs
  22  Respiratory organ agents
   229  Miscellaneous
    2290  Miscellaneous
     D06315  Fluticasone furoate (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D06315  Fluticasone furoate (JAN/USAN/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06315
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06315
Rx-to-OTC switch list in the USA [br08315.html]
 D06315
BRITE hierarchy
Other DBs
CAS: 397864-44-7
PubChem: 47207972
ChEBI: 74899
ChEMBL: CHEMBL1676
PDB-CCD: GW6[PDBj]
LigandBox: D06315
LinkDB All DBs
KCF data Show

ATOM        37
            1   C2x C    19.6000  -28.4200
            2   C5x C    19.6000  -29.7500
            3   C2x C    20.7900  -30.4500
            4   C2y C    21.9100  -29.7500
            5   C1z C    21.9100  -28.4200
            6   C2x C    20.7900  -27.7200
            7   C1y C    23.1000  -30.4500
            8   C1x C    24.3600  -29.7500
            9   C1y C    24.3600  -28.4200
            10  C1z C    23.1000  -27.7200
            11  C1y C    25.4100  -27.7200
            12  C1z C    25.4100  -26.3900
            13  C1x C    24.3600  -25.6900
            14  C1y C    23.1000  -26.3900
            15  C1x C    27.7200  -27.7200
            16  C1y C    27.7200  -26.3900
            17  C1z C    26.5300  -25.6900
            18  O5x O    18.4100  -30.4500
            19  C1a C    21.9100  -27.0200
            20  X   F    23.1000  -29.0500
            21  O1a O    21.9100  -25.6900
            22  C1a C    25.4100  -24.9900
            23  O7a O    27.9300  -24.7800
            24  C1a C    29.1200  -26.3900
            25  X   F    23.1000  -31.8500
            26  C5a C    26.5300  -24.2900
            27  O5a O    27.7900  -23.5900
            28  S2a S    25.2700  -23.5900
            29  C1b C    24.0800  -24.2900
            30  X   F    22.8900  -23.5900
            31  C7a C    29.1200  -24.0800
            32  C8y C    30.3100  -24.7800
            33  O6a O    29.1200  -22.6800
            34  C8x C    30.8000  -26.1100
            35  C8x C    32.2000  -26.1100
            36  C8x C    32.6200  -24.7800
            37  O2x O    31.4300  -23.9400
BOND        41
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   10  20 1 #Down
            24   14  21 1 #Up
            25   12  22 1 #Up
            26   17  23 1 #Down
            27   16  24 1 #Down
            28    7  25 1 #Down
            29   17  26 1 #Up
            30   26  27 2
            31   26  28 1
            32   28  29 1
            33   29  30 1
            34   31  32 1
            35   31  23 1
            36   31  33 2
            37   32  34 2
            38   34  35 1
            39   35  36 2
            40   36  37 1
            41   32  37 1

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