| Entry |
|
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| Name |
Nilvadipine (JP18/USAN/INN);
Nivadil (TN) |
|---|
| Formula |
C19H19N3O6
|
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| Exact mass |
385.1274
|
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| Mol weight |
385.37
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 2149 |
|
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| Efficacy |
Antihypertensive, Calcium channel blocker |
|---|
| Comment |
Dihydropyridine derivative
|
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| Target |
|
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| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA10 Nilvadipine
D01908 Nilvadipine (JP18/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D01908 Nilvadipine (JP18/USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
D01908 Nilvadipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
D01908 Nilvadipine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D01908 Nilvadipine
Drug classes [BR:br08332]
Cardiovascular agent
DG01928 Dihydropyridine calcium channel blocker
D01908 Nilvadipine
DG03231 Antihypertensive
D01908 Nilvadipine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D01908 Nilvadipine (JP18/USAN/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01908 Nilvadipine
D01908 Nilvadipine tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01908
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 28
1 C1y C 25.7019 -15.9679
2 C2y C 26.8926 -15.2676
3 C2y C 24.4413 -15.2676
4 C8y C 25.7019 -17.3687
5 C2y C 26.8926 -13.8668
6 C7a C 28.0832 -15.9679
7 C2y C 24.4413 -13.8668
8 C7a C 23.2507 -15.9679
9 C8x C 26.8926 -18.0690
10 C8x C 24.5113 -18.0690
11 N1x N 25.7019 -13.1665
12 C3b C 28.0832 -13.1665
13 O7a O 29.3439 -15.2676
14 O6a O 28.0832 -17.3687
15 C1a C 23.2507 -13.1665
16 O7a O 22.0600 -15.2676
17 O6a O 23.2507 -17.3687
18 C8y C 26.8926 -19.4698
19 C8x C 24.5113 -19.4698
20 C1a C 30.5345 -15.9679
21 C1c C 20.7994 -15.9679
22 C8x C 25.7019 -20.1701
23 N2b N 28.1532 -20.1701 #+
24 O3a O 29.6239 -19.2598
25 O3a O 28.1532 -21.5709 #-
26 C1a C 20.7994 -17.3687
27 C1a C 19.6087 -15.2676
28 N3a N 29.3439 -12.4661
BOND 29
1 1 4 1
2 2 5 2
3 2 6 1
4 3 7 2
5 3 8 1
6 4 9 1
7 4 10 2
8 5 11 1
9 5 12 1
10 6 13 1
11 6 14 2
12 7 15 1
13 8 16 1
14 8 17 2
15 9 18 2
16 10 19 1
17 13 20 1
18 16 21 1
19 18 22 1
20 18 23 1
21 23 24 2
22 23 25 1
23 7 11 1
24 19 22 2
25 21 26 1
26 1 2 1
27 21 27 1
28 1 3 1
29 12 28 3
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