Entry |
|
Name |
Eletriptan hydrobromide (JAN/USAN); Relpax (TN) |
Product |
|
Generic |
|
Formula |
C22H26N2O2S. HBr
|
Exact mass |
462.0977
|
Mol weight |
463.431
|
Structure |
|
Simcomp |
|
Class |
Analgesic
DG01484 5-HT1B-receptor agonist
DG01485 5-HT1D-receptor agonist
DG01518 5-HT1B/1D-receptor agonist
DG01943 Triptan
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
Remark |
Therapeutic category: | 2160 |
Product (DG00840): | D01973<JP/US> |
|
Efficacy |
Antimigraine, Vasoconstrictor, Serotonin receptor agonist |
Comment |
Sumatriptan derivative
|
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
Interaction |
|
Structure map |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02C ANTIMIGRAINE PREPARATIONS
N02CC Selective serotonin (5HT1) agonists
N02CC06 Eletriptan
D01973 Eletriptan hydrobromide (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
Antimigraine Agents
Serotonin (5-HT) Receptor Agonists
Eletriptan
D01973 Eletriptan hydrobromide (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
216 Vasoconstrictors
2160 Vasoconstrictors
D01973 Eletriptan hydrobromide (JAN/USAN)
Drug groups [BR:br08330]
Analgesic
DG01484 5-HT1B-receptor agonist
DG00840 Eletriptan
D01973 Eletriptan hydrobromide
DG01485 5-HT1D-receptor agonist
DG00840 Eletriptan
D01973 Eletriptan hydrobromide
DG01518 5-HT1B/1D-receptor agonist
DG00840 Eletriptan
D01973 Eletriptan hydrobromide
DG01943 Triptan
DG00840 Eletriptan
D01973 Eletriptan hydrobromide
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00840 Eletriptan
D01973 Eletriptan hydrobromide
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Serotonin
HTR1B
D01973 Eletriptan hydrobromide (JAN/USAN) <JP/US>
HTR1D
D01973 Eletriptan hydrobromide (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D01973
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D01973
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D01973
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01973
Drug groups [BR:br08330]
Analgesic
DG01484 5-HT1B-receptor agonist
DG00840 Eletriptan
DG01485 5-HT1D-receptor agonist
DG00840 Eletriptan
DG01518 5-HT1B/1D-receptor agonist
DG00840 Eletriptan
DG01943 Triptan
DG00840 Eletriptan
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00840 Eletriptan
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 28
1 X Br 24.7100 -15.8900
2 C1y C 22.4224 -12.6000
3 N1y N 22.4224 -11.2000
4 C1a C 21.1933 -10.4902
5 C1x C 23.7539 -13.0326
6 C1x C 24.5768 -11.9000
7 C1x C 23.7539 -10.7674
8 C8x C 17.4300 -16.5200
9 C8y C 17.4300 -15.1200
10 C8x C 18.6900 -14.4200
11 C8y C 19.8800 -15.1200
12 C8y C 19.8800 -16.5200
13 C8x C 18.6900 -17.2200
14 C8y C 21.2100 -14.7000
15 C8x C 22.0500 -15.8200
16 N4x N 21.2100 -16.9400
17 C1b C 16.2400 -14.4200
18 C1b C 15.0500 -15.1200
19 S4a S 13.8600 -14.4200
20 C8y C 12.6000 -15.1200
21 C8x C 12.6000 -16.5200
22 C8x C 11.4100 -17.2200
23 C8x C 10.2200 -16.5200
24 C8x C 10.2200 -15.1200
25 C8x C 11.4100 -14.4200
26 C1b C 21.2100 -13.3000
27 O3c O 14.8499 -13.4301
28 O3c O 12.8701 -13.4301
BOND 30
1 2 3 1
2 3 4 1
3 2 5 1
4 5 6 1
5 6 7 1
6 3 7 1
7 8 9 2
8 9 10 1
9 10 11 2
10 11 12 1
11 12 13 2
12 8 13 1
13 11 14 1
14 14 15 2
15 15 16 1
16 12 16 1
17 9 17 1
18 17 18 1
19 18 19 1
20 19 20 1
21 20 21 2
22 21 22 1
23 22 23 2
24 23 24 1
25 24 25 2
26 20 25 1
27 14 26 1
28 2 26 1 #Down
29 19 27 2
30 19 28 2
|