| Entry |
|
|---|
| Name |
Tetracosactide acetate (JAN);
Cortrosyn (TN) |
|---|
| Formula |
C136H210N40O31S. (C2H4O2)x
|
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| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Hormonal agent
DG01629 Adrenocorticotropic hormone (ACTH)
|
|---|
| Remark |
| Therapeutic category: | 2411 |
| Product (DG00493): | D00284<US> D02105<JP> |
|
|---|
| Efficacy |
Diagnostic (adrenocortical function), Melanocortin 2 receptor agonist |
|---|
| Comment |
Adrenocorticotropic hormone (ACTH)
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04925 | Aldosterone synthesis and secretion |
| hsa04927 | Cortisol synthesis and secretion |
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
H01A ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
H01AA ACTH
H01AA02 Tetracosactide
D02105 Tetracosactide acetate (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
241 Pituitary hormone preparations
2411 ACTHs
D02105 Tetracosactide acetate (JAN)
Drug groups [BR:br08330]
Hormonal agent
DG01629 Adrenocorticotropic hormone (ACTH)
DG00493 Tetracosactide
D02105 Tetracosactide acetate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Melanocortin
MC2R
D02105 Tetracosactide acetate (JAN) <JP>
Drug groups [BR:br08330]
Hormonal agent
DG01629 Adrenocorticotropic hormone (ACTH)
DG00493 Tetracosactide
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 212
1 C8y C 40.3900 -47.5300
2 C8y C 40.0400 -46.2700
3 C8y C 41.7900 -47.5300
4 C8x C 39.6900 -48.7200
5 C1b C 38.5000 -46.2700
6 C8x C 41.0900 -45.4300
7 N4x N 42.2100 -46.2700
8 C8x C 42.4900 -48.7900
9 C8x C 40.3900 -49.9800
10 C1c C 37.2400 -45.6400
11 C8x C 41.7900 -49.9800
12 N1b N 37.2400 -44.2400
13 C5a C 36.1200 -46.4100
14 C5a C 38.3600 -43.4700
15 N1b N 36.1200 -47.8100
16 O5a O 35.0700 -45.6400
17 C1c C 38.3600 -42.0700
18 O5a O 39.6200 -44.0300
19 C1b C 35.0000 -48.5800
20 N1b N 39.4800 -41.2300
21 C1b C 37.1700 -41.4400
22 C5a C 33.6700 -47.9500
23 C5a C 39.4800 -39.8300
24 C1b C 37.1700 -40.0400
25 N1b N 33.6700 -46.5500
26 O5a O 32.6200 -48.7900
27 C1c C 40.6000 -39.0600
28 O5a O 38.2900 -39.2700
29 C1b C 35.9100 -39.3400
30 C1c C 32.4100 -45.8500
31 N1b N 40.6000 -37.7300
32 C1b C 41.8600 -39.6900
33 N1b N 35.9100 -37.9400
34 C5a C 32.4100 -44.4500
35 C1b C 31.2900 -46.6200
36 C5a C 41.7200 -36.8900
37 C8y C 41.8600 -41.1600
38 C2c C 34.6500 -37.3800
39 N1y N 31.2200 -43.8200
40 O5a O 33.6000 -43.6800
41 C1b C 30.1000 -46.0600
42 C1c C 41.7200 -35.4900
43 O5a O 42.9800 -37.5900
44 C8x C 40.7400 -41.8600
45 C8x C 43.1200 -41.7900
46 N1a N 34.6500 -35.9100
47 N2a N 33.5300 -38.1500
48 C1y C 31.0800 -42.4200
49 C1x C 29.9600 -44.5200
50 C1b C 28.9100 -46.7600
51 C1b C 40.6700 -34.9300
52 N1b N 42.9100 -34.7200
53 C8x C 40.7400 -43.3300
54 C8x C 43.1200 -43.1900
55 C1x C 29.6800 -42.2800
56 C5a C 32.0600 -41.5800
57 C1x C 29.0500 -43.4700
58 C1b C 27.7200 -46.1300
59 C8y C 39.4100 -35.4900
60 C5a C 42.9100 -33.3200
61 C8x C 42.0000 -43.9600
62 N1b N 32.0600 -40.1100
63 O5a O 33.3900 -42.2800
64 N1a N 26.5300 -46.9000
65 C8x C 39.0600 -36.9600
66 N5x N 38.1500 -34.8600
67 C1c C 44.0300 -32.5500
68 O5a O 41.6500 -32.6900
69 C1c C 30.9400 -39.4800
70 N4x N 37.7300 -37.1000
71 C8x C 37.1000 -35.8400
72 N1b N 44.0300 -31.1500
73 C1b C 45.2900 -33.2500
74 C5a C 30.9400 -38.0800
75 C1c C 29.8200 -40.3200
76 C5a C 45.1500 -30.3800
77 C1b C 45.2900 -34.5800
78 N1b N 29.6800 -37.4500
79 O5a O 32.1300 -37.3100
80 C1a C 29.8200 -41.5800
81 C1a C 28.5600 -39.6200
82 C1c C 45.1500 -28.9800
83 O5a O 46.3400 -31.0100
84 C6a C 46.4800 -35.2100
85 C1b C 29.6800 -36.0500
86 N1b N 46.2700 -28.2100
87 C1b C 43.8900 -28.3500
88 O6a O 46.4800 -36.6100
89 O6a O 47.6700 -34.4400
90 C5a C 28.4900 -35.4200
91 C5a C 46.2700 -26.8100
92 C1b C 43.8900 -26.9500
93 N1b N 28.4900 -33.9500
94 O5a O 27.3700 -36.1200
95 C1c C 47.3900 -26.0400
96 O5a O 45.0800 -26.1800
97 S2a S 42.7000 -26.3200
98 C1c C 29.6800 -33.2500
99 N1b N 47.3900 -24.7100
100 C1b C 48.6500 -26.6700
101 C1a C 41.7200 -27.5800
102 C5a C 29.6800 -31.8500
103 C1b C 30.8700 -33.8800
104 C5a C 48.5100 -23.8700
105 O1a O 48.6500 -28.0700
106 N1b N 30.8000 -31.0800
107 O5a O 28.4900 -31.1500
108 C1b C 32.0600 -33.1100
109 C1c C 48.5100 -22.4700
110 O5a O 49.7700 -24.5000
111 C1c C 30.8000 -29.6100
112 C1b C 33.2500 -33.7400
113 C1b C 49.7000 -21.7000
114 N1b N 47.3200 -21.8400
115 C5a C 31.9200 -28.8400
116 C1b C 29.6100 -29.0500
117 C1b C 34.4400 -32.9700
118 C8y C 49.7000 -20.3000
119 C5a C 46.1300 -22.6100
120 N1b N 31.9200 -27.5100
121 O5a O 33.1800 -29.5400
122 C1b C 28.4200 -29.8200
123 N1a N 35.6300 -33.6000
124 C8x C 48.3700 -19.6700
125 C8x C 50.8200 -19.5300
126 C1c C 44.9400 -21.9800
127 O5a O 46.1300 -23.7300
128 C1c C 33.1100 -26.7400
129 C1b C 27.2300 -29.1900
130 C8x C 48.3700 -18.2700
131 C8x C 50.8200 -18.1300
132 C1b C 43.7500 -22.7500
133 N1a N 44.9400 -20.5800
134 C5a C 33.1100 -25.3400
135 C1b C 34.3700 -27.3700
136 C1b C 26.0400 -29.8900
137 C8y C 49.5600 -17.5000
138 O1a O 43.7500 -24.2900
139 N1b N 34.3000 -24.5700
140 O5a O 31.9200 -24.7100
141 C1b C 35.4900 -26.6000
142 N1a N 24.8500 -29.2600
143 O1a O 49.5600 -16.1000
144 C1c C 34.3000 -23.1700
145 C1b C 36.6800 -27.2300
146 C5a C 33.1100 -22.5400
147 C1b C 35.4900 -22.4000
148 N1b N 37.8700 -26.4600
149 N1y N 33.1100 -21.1400
150 O5a O 31.8500 -23.3100
151 C1b C 36.6800 -23.0300
152 C2c C 39.1300 -27.0900
153 C1y C 33.6700 -19.8800
154 C1x C 31.7100 -20.9300
155 C1b C 37.8000 -22.2600
156 N1a N 40.2500 -26.3200
157 N2a N 39.1300 -28.4900
158 C1x C 32.7600 -18.9000
159 C5a C 34.9300 -19.1100
160 C1x C 31.5000 -19.5300
161 N1b N 38.9900 -22.9600
162 N1b N 34.9300 -17.7100
163 O5a O 36.1200 -19.7400
164 C2c C 40.1800 -22.1900
165 C1c C 35.9800 -16.9400
166 N1a N 41.3700 -22.7500
167 N2a N 40.1800 -20.7200
168 C5a C 35.9800 -15.4700
169 C1c C 37.2400 -17.5700
170 N1b N 37.1000 -14.7700
171 O5a O 34.7900 -14.9100
172 C1a C 38.4300 -16.8000
173 C1a C 37.2400 -18.9700
174 C1c C 37.1000 -13.3000
175 C5a C 38.2200 -12.6000
176 C1b C 35.9100 -12.7400
177 N1b N 38.2200 -11.2000
178 O5a O 39.5500 -13.2300
179 C1b C 34.7200 -13.5100
180 C1c C 39.3400 -10.4300
181 C1b C 33.4600 -12.8800
182 C5a C 39.3400 -9.1000
183 C1c C 40.6700 -11.0600
184 C1b C 32.2700 -13.6500
185 N1b N 38.0800 -8.4000
186 O5a O 40.6000 -8.3300
187 C1a C 40.6700 -12.5300
188 C1a C 41.8600 -10.2900
189 N1a N 31.0800 -12.9500
190 C1c C 38.0800 -6.9300
191 C5a C 39.2700 -6.0900
192 C1b C 36.7500 -6.2300
193 N1y N 39.2700 -4.6900
194 O5a O 40.6000 -6.8600
195 C8y C 35.4900 -7.0700
196 C1y C 40.6000 -3.9900
197 C1x C 38.2900 -3.5700
198 C8x C 34.1600 -6.3000
199 C8x C 35.4900 -8.4700
200 C1x C 40.3900 -2.5200
201 C6a C 41.9300 -4.6900
202 C1x C 38.9200 -2.3100
203 C8x C 32.9700 -7.0700
204 C8x C 34.3000 -9.2400
205 O6a O 43.1900 -3.8500
206 O6a O 41.9300 -6.2300
207 C8y C 32.9700 -8.6100
208 O1a O 31.7100 -9.3100
209 C1a C 55.0900 -23.6600
210 C6a C 56.3024 -22.9600
211 O6a O 57.5149 -23.6600
212 O6a O 56.3024 -21.5602
BOND 219
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 1
7 3 8 1
8 4 9 2
9 10 5 1 #Up
10 8 11 2
11 10 12 1
12 10 13 1
13 12 14 1
14 13 15 1
15 13 16 2
16 14 17 1
17 14 18 2
18 15 19 1
19 17 20 1
20 17 21 1 #Down
21 19 22 1
22 20 23 1
23 21 24 1
24 22 25 1
25 22 26 2
26 23 27 1
27 23 28 2
28 24 29 1
29 25 30 1
30 27 31 1
31 27 32 1 #Up
32 29 33 1
33 30 34 1
34 30 35 1 #Up
35 31 36 1
36 32 37 1
37 33 38 1
38 34 39 1
39 34 40 2
40 35 41 1
41 36 42 1
42 36 43 2
43 37 44 2
44 37 45 1
45 38 46 1
46 38 47 2
47 39 48 1
48 39 49 1
49 41 50 1
50 42 51 1 #Down
51 42 52 1
52 44 53 1
53 45 54 2
54 48 55 1
55 48 56 1 #Up
56 49 57 1
57 50 58 1
58 51 59 1
59 52 60 1
60 53 61 2
61 56 62 1
62 56 63 2
63 58 64 1
64 59 65 2
65 59 66 1
66 60 67 1
67 60 68 2
68 62 69 1
69 65 70 1
70 66 71 2
71 67 72 1
72 67 73 1 #Up
73 69 74 1
74 69 75 1 #Up
75 72 76 1
76 73 77 1
77 74 78 1
78 74 79 2
79 75 80 1
80 75 81 1
81 76 82 1
82 76 83 2
83 77 84 1
84 78 85 1
85 82 86 1
86 82 87 1 #Down
87 84 88 1
88 84 89 2
89 85 90 1
90 86 91 1
91 87 92 1
92 90 93 1
93 90 94 2
94 91 95 1
95 91 96 2
96 92 97 1
97 93 98 1
98 95 99 1
99 95 100 1 #Up
100 97 101 1
101 98 102 1
102 98 103 1 #Up
103 99 104 1
104 100 105 1
105 102 106 1
106 102 107 2
107 103 108 1
108 104 109 1
109 104 110 2
110 106 111 1
111 108 112 1
112 109 113 1
113 109 114 1 #Up
114 111 115 1
115 111 116 1 #Down
116 112 117 1
117 113 118 1
118 114 119 1
119 115 120 1
120 115 121 2
121 116 122 1
122 117 123 1
123 118 124 1
124 118 125 2
125 119 126 1
126 119 127 2
127 120 128 1
128 122 129 1
129 124 130 2
130 125 131 1
131 126 132 1
132 126 133 1
133 128 134 1
134 128 135 1 #Up
135 129 136 1
136 130 137 1
137 132 138 1
138 134 139 1
139 134 140 2
140 135 141 1
141 136 142 1
142 137 143 1
143 139 144 1
144 141 145 1
145 144 146 1
146 144 147 1 #Up
147 145 148 1
148 146 149 1
149 146 150 2
150 147 151 1
151 148 152 1
152 149 153 1
153 149 154 1
154 151 155 1
155 152 156 1
156 152 157 2
157 153 158 1
158 153 159 1 #Up
159 154 160 1
160 155 161 1
161 159 162 1
162 159 163 2
163 161 164 1
164 162 165 1
165 164 166 1
166 164 167 2
167 165 168 1
168 165 169 1 #Down
169 168 170 1
170 168 171 2
171 169 172 1
172 169 173 1
173 170 174 1
174 174 175 1
175 174 176 1 #Up
176 175 177 1
177 175 178 2
178 176 179 1
179 177 180 1
180 179 181 1
181 180 182 1
182 180 183 1 #Down
183 181 184 1
184 182 185 1
185 182 186 2
186 183 187 1
187 183 188 1
188 184 189 1
189 185 190 1
190 190 191 1
191 190 192 1 #Up
192 191 193 1
193 191 194 2
194 192 195 1
195 193 196 1
196 193 197 1
197 195 198 2
198 195 199 1
199 196 200 1
200 196 201 1 #Up
201 197 202 1
202 198 203 1
203 199 204 2
204 201 205 1
205 201 206 2
206 203 207 2
207 207 208 1
208 6 7 1
209 9 11 1
210 54 61 1
211 55 57 1
212 70 71 1
213 131 137 2
214 158 160 1
215 200 202 1
216 204 207 1
217 209 210 1
218 210 211 1
219 210 212 2
BRACKET 1 53.2700 -24.5000 53.2700 -21.0000
1 58.8000 -21.0000 58.8000 -24.5000
1 x
ORIGINAL 1 209 210 211 212
REPEAT 1
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