KEGG   DRUG: Tetracosactide acetate
Entry
D02105                      Drug                                   

Name
Tetracosactide acetate (JAN);
Cortrosyn (TN)
Formula
C136H210N40O31S. (C2H4O2)x
Structure
Simcomp
Class
Other
 DG01629  Adrenocorticotropic hormone (ACTH)
Remark
Therapeutic category: 2411
ATC code: H01AA02
Chemical structure group: DG00493
Product (DG00493): D00284<US> D02105<JP>
Efficacy
Diagnostic (adrenocortical function), Melanocortin 2 receptor agonist
Comment
Adrenocorticotropic hormone (ACTH)
Target
MC2R [HSA:4158] [KO:K04200]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04925  Aldosterone synthesis and secretion
hsa04927  Cortisol synthesis and secretion
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01A ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
    H01AA ACTH
     H01AA02 Tetracosactide
      D02105  Tetracosactide acetate (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   241  Pituitary hormone preparations
    2411  ACTHs
     D02105  Tetracosactide acetate (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Melanocortin
    MC2R
     D02105  Tetracosactide acetate (JAN) <JP>
Other DBs
CAS: 60189-34-6
PubChem: 7849166
NIKKAJI: J2.208.446A
LinkDB
KCF data

ATOM        212
            1   C8y C    40.3900  -47.5300
            2   C8y C    40.0400  -46.2700
            3   C8y C    41.7900  -47.5300
            4   C8x C    39.6900  -48.7200
            5   C1b C    38.5000  -46.2700
            6   C8x C    41.0900  -45.4300
            7   N4x N    42.2100  -46.2700
            8   C8x C    42.4900  -48.7900
            9   C8x C    40.3900  -49.9800
            10  C1c C    37.2400  -45.6400
            11  C8x C    41.7900  -49.9800
            12  N1b N    37.2400  -44.2400
            13  C5a C    36.1200  -46.4100
            14  C5a C    38.3600  -43.4700
            15  N1b N    36.1200  -47.8100
            16  O5a O    35.0700  -45.6400
            17  C1c C    38.3600  -42.0700
            18  O5a O    39.6200  -44.0300
            19  C1b C    35.0000  -48.5800
            20  N1b N    39.4800  -41.2300
            21  C1b C    37.1700  -41.4400
            22  C5a C    33.6700  -47.9500
            23  C5a C    39.4800  -39.8300
            24  C1b C    37.1700  -40.0400
            25  N1b N    33.6700  -46.5500
            26  O5a O    32.6200  -48.7900
            27  C1c C    40.6000  -39.0600
            28  O5a O    38.2900  -39.2700
            29  C1b C    35.9100  -39.3400
            30  C1c C    32.4100  -45.8500
            31  N1b N    40.6000  -37.7300
            32  C1b C    41.8600  -39.6900
            33  N1b N    35.9100  -37.9400
            34  C5a C    32.4100  -44.4500
            35  C1b C    31.2900  -46.6200
            36  C5a C    41.7200  -36.8900
            37  C8y C    41.8600  -41.1600
            38  C2c C    34.6500  -37.3800
            39  N1y N    31.2200  -43.8200
            40  O5a O    33.6000  -43.6800
            41  C1b C    30.1000  -46.0600
            42  C1c C    41.7200  -35.4900
            43  O5a O    42.9800  -37.5900
            44  C8x C    40.7400  -41.8600
            45  C8x C    43.1200  -41.7900
            46  N1a N    34.6500  -35.9100
            47  N2a N    33.5300  -38.1500
            48  C1y C    31.0800  -42.4200
            49  C1x C    29.9600  -44.5200
            50  C1b C    28.9100  -46.7600
            51  C1b C    40.6700  -34.9300
            52  N1b N    42.9100  -34.7200
            53  C8x C    40.7400  -43.3300
            54  C8x C    43.1200  -43.1900
            55  C1x C    29.6800  -42.2800
            56  C5a C    32.0600  -41.5800
            57  C1x C    29.0500  -43.4700
            58  C1b C    27.7200  -46.1300
            59  C8y C    39.4100  -35.4900
            60  C5a C    42.9100  -33.3200
            61  C8x C    42.0000  -43.9600
            62  N1b N    32.0600  -40.1100
            63  O5a O    33.3900  -42.2800
            64  N1a N    26.5300  -46.9000
            65  C8x C    39.0600  -36.9600
            66  N5x N    38.1500  -34.8600
            67  C1c C    44.0300  -32.5500
            68  O5a O    41.6500  -32.6900
            69  C1c C    30.9400  -39.4800
            70  N4x N    37.7300  -37.1000
            71  C8x C    37.1000  -35.8400
            72  N1b N    44.0300  -31.1500
            73  C1b C    45.2900  -33.2500
            74  C5a C    30.9400  -38.0800
            75  C1c C    29.8200  -40.3200
            76  C5a C    45.1500  -30.3800
            77  C1b C    45.2900  -34.5800
            78  N1b N    29.6800  -37.4500
            79  O5a O    32.1300  -37.3100
            80  C1a C    29.8200  -41.5800
            81  C1a C    28.5600  -39.6200
            82  C1c C    45.1500  -28.9800
            83  O5a O    46.3400  -31.0100
            84  C6a C    46.4800  -35.2100
            85  C1b C    29.6800  -36.0500
            86  N1b N    46.2700  -28.2100
            87  C1b C    43.8900  -28.3500
            88  O6a O    46.4800  -36.6100
            89  O6a O    47.6700  -34.4400
            90  C5a C    28.4900  -35.4200
            91  C5a C    46.2700  -26.8100
            92  C1b C    43.8900  -26.9500
            93  N1b N    28.4900  -33.9500
            94  O5a O    27.3700  -36.1200
            95  C1c C    47.3900  -26.0400
            96  O5a O    45.0800  -26.1800
            97  S2a S    42.7000  -26.3200
            98  C1c C    29.6800  -33.2500
            99  N1b N    47.3900  -24.7100
            100 C1b C    48.6500  -26.6700
            101 C1a C    41.7200  -27.5800
            102 C5a C    29.6800  -31.8500
            103 C1b C    30.8700  -33.8800
            104 C5a C    48.5100  -23.8700
            105 O1a O    48.6500  -28.0700
            106 N1b N    30.8000  -31.0800
            107 O5a O    28.4900  -31.1500
            108 C1b C    32.0600  -33.1100
            109 C1c C    48.5100  -22.4700
            110 O5a O    49.7700  -24.5000
            111 C1c C    30.8000  -29.6100
            112 C1b C    33.2500  -33.7400
            113 C1b C    49.7000  -21.7000
            114 N1b N    47.3200  -21.8400
            115 C5a C    31.9200  -28.8400
            116 C1b C    29.6100  -29.0500
            117 C1b C    34.4400  -32.9700
            118 C8y C    49.7000  -20.3000
            119 C5a C    46.1300  -22.6100
            120 N1b N    31.9200  -27.5100
            121 O5a O    33.1800  -29.5400
            122 C1b C    28.4200  -29.8200
            123 N1a N    35.6300  -33.6000
            124 C8x C    48.3700  -19.6700
            125 C8x C    50.8200  -19.5300
            126 C1c C    44.9400  -21.9800
            127 O5a O    46.1300  -23.7300
            128 C1c C    33.1100  -26.7400
            129 C1b C    27.2300  -29.1900
            130 C8x C    48.3700  -18.2700
            131 C8x C    50.8200  -18.1300
            132 C1b C    43.7500  -22.7500
            133 N1a N    44.9400  -20.5800
            134 C5a C    33.1100  -25.3400
            135 C1b C    34.3700  -27.3700
            136 C1b C    26.0400  -29.8900
            137 C8y C    49.5600  -17.5000
            138 O1a O    43.7500  -24.2900
            139 N1b N    34.3000  -24.5700
            140 O5a O    31.9200  -24.7100
            141 C1b C    35.4900  -26.6000
            142 N1a N    24.8500  -29.2600
            143 O1a O    49.5600  -16.1000
            144 C1c C    34.3000  -23.1700
            145 C1b C    36.6800  -27.2300
            146 C5a C    33.1100  -22.5400
            147 C1b C    35.4900  -22.4000
            148 N1b N    37.8700  -26.4600
            149 N1y N    33.1100  -21.1400
            150 O5a O    31.8500  -23.3100
            151 C1b C    36.6800  -23.0300
            152 C2c C    39.1300  -27.0900
            153 C1y C    33.6700  -19.8800
            154 C1x C    31.7100  -20.9300
            155 C1b C    37.8000  -22.2600
            156 N1a N    40.2500  -26.3200
            157 N2a N    39.1300  -28.4900
            158 C1x C    32.7600  -18.9000
            159 C5a C    34.9300  -19.1100
            160 C1x C    31.5000  -19.5300
            161 N1b N    38.9900  -22.9600
            162 N1b N    34.9300  -17.7100
            163 O5a O    36.1200  -19.7400
            164 C2c C    40.1800  -22.1900
            165 C1c C    35.9800  -16.9400
            166 N1a N    41.3700  -22.7500
            167 N2a N    40.1800  -20.7200
            168 C5a C    35.9800  -15.4700
            169 C1c C    37.2400  -17.5700
            170 N1b N    37.1000  -14.7700
            171 O5a O    34.7900  -14.9100
            172 C1a C    38.4300  -16.8000
            173 C1a C    37.2400  -18.9700
            174 C1c C    37.1000  -13.3000
            175 C5a C    38.2200  -12.6000
            176 C1b C    35.9100  -12.7400
            177 N1b N    38.2200  -11.2000
            178 O5a O    39.5500  -13.2300
            179 C1b C    34.7200  -13.5100
            180 C1c C    39.3400  -10.4300
            181 C1b C    33.4600  -12.8800
            182 C5a C    39.3400   -9.1000
            183 C1c C    40.6700  -11.0600
            184 C1b C    32.2700  -13.6500
            185 N1b N    38.0800   -8.4000
            186 O5a O    40.6000   -8.3300
            187 C1a C    40.6700  -12.5300
            188 C1a C    41.8600  -10.2900
            189 N1a N    31.0800  -12.9500
            190 C1c C    38.0800   -6.9300
            191 C5a C    39.2700   -6.0900
            192 C1b C    36.7500   -6.2300
            193 N1y N    39.2700   -4.6900
            194 O5a O    40.6000   -6.8600
            195 C8y C    35.4900   -7.0700
            196 C1y C    40.6000   -3.9900
            197 C1x C    38.2900   -3.5700
            198 C8x C    34.1600   -6.3000
            199 C8x C    35.4900   -8.4700
            200 C1x C    40.3900   -2.5200
            201 C6a C    41.9300   -4.6900
            202 C1x C    38.9200   -2.3100
            203 C8x C    32.9700   -7.0700
            204 C8x C    34.3000   -9.2400
            205 O6a O    43.1900   -3.8500
            206 O6a O    41.9300   -6.2300
            207 C8y C    32.9700   -8.6100
            208 O1a O    31.7100   -9.3100
            209 C1a C    55.0900  -23.6600
            210 C6a C    56.3024  -22.9600
            211 O6a O    57.5149  -23.6600
            212 O6a O    56.3024  -21.5602
BOND        219
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9    10   5 1 #Up
            10    8  11 2
            11   10  12 1
            12   10  13 1
            13   12  14 1
            14   13  15 1
            15   13  16 2
            16   14  17 1
            17   14  18 2
            18   15  19 1
            19   17  20 1
            20   17  21 1 #Down
            21   19  22 1
            22   20  23 1
            23   21  24 1
            24   22  25 1
            25   22  26 2
            26   23  27 1
            27   23  28 2
            28   24  29 1
            29   25  30 1
            30   27  31 1
            31   27  32 1 #Up
            32   29  33 1
            33   30  34 1
            34   30  35 1 #Up
            35   31  36 1
            36   32  37 1
            37   33  38 1
            38   34  39 1
            39   34  40 2
            40   35  41 1
            41   36  42 1
            42   36  43 2
            43   37  44 2
            44   37  45 1
            45   38  46 1
            46   38  47 2
            47   39  48 1
            48   39  49 1
            49   41  50 1
            50   42  51 1 #Down
            51   42  52 1
            52   44  53 1
            53   45  54 2
            54   48  55 1
            55   48  56 1 #Up
            56   49  57 1
            57   50  58 1
            58   51  59 1
            59   52  60 1
            60   53  61 2
            61   56  62 1
            62   56  63 2
            63   58  64 1
            64   59  65 2
            65   59  66 1
            66   60  67 1
            67   60  68 2
            68   62  69 1
            69   65  70 1
            70   66  71 2
            71   67  72 1
            72   67  73 1 #Up
            73   69  74 1
            74   69  75 1 #Up
            75   72  76 1
            76   73  77 1
            77   74  78 1
            78   74  79 2
            79   75  80 1
            80   75  81 1
            81   76  82 1
            82   76  83 2
            83   77  84 1
            84   78  85 1
            85   82  86 1
            86   82  87 1 #Down
            87   84  88 1
            88   84  89 2
            89   85  90 1
            90   86  91 1
            91   87  92 1
            92   90  93 1
            93   90  94 2
            94   91  95 1
            95   91  96 2
            96   92  97 1
            97   93  98 1
            98   95  99 1
            99   95 100 1 #Up
            100  97 101 1
            101  98 102 1
            102  98 103 1 #Up
            103  99 104 1
            104 100 105 1
            105 102 106 1
            106 102 107 2
            107 103 108 1
            108 104 109 1
            109 104 110 2
            110 106 111 1
            111 108 112 1
            112 109 113 1
            113 109 114 1 #Up
            114 111 115 1
            115 111 116 1 #Down
            116 112 117 1
            117 113 118 1
            118 114 119 1
            119 115 120 1
            120 115 121 2
            121 116 122 1
            122 117 123 1
            123 118 124 1
            124 118 125 2
            125 119 126 1
            126 119 127 2
            127 120 128 1
            128 122 129 1
            129 124 130 2
            130 125 131 1
            131 126 132 1
            132 126 133 1
            133 128 134 1
            134 128 135 1 #Up
            135 129 136 1
            136 130 137 1
            137 132 138 1
            138 134 139 1
            139 134 140 2
            140 135 141 1
            141 136 142 1
            142 137 143 1
            143 139 144 1
            144 141 145 1
            145 144 146 1
            146 144 147 1 #Up
            147 145 148 1
            148 146 149 1
            149 146 150 2
            150 147 151 1
            151 148 152 1
            152 149 153 1
            153 149 154 1
            154 151 155 1
            155 152 156 1
            156 152 157 2
            157 153 158 1
            158 153 159 1 #Up
            159 154 160 1
            160 155 161 1
            161 159 162 1
            162 159 163 2
            163 161 164 1
            164 162 165 1
            165 164 166 1
            166 164 167 2
            167 165 168 1
            168 165 169 1 #Down
            169 168 170 1
            170 168 171 2
            171 169 172 1
            172 169 173 1
            173 170 174 1
            174 174 175 1
            175 174 176 1 #Up
            176 175 177 1
            177 175 178 2
            178 176 179 1
            179 177 180 1
            180 179 181 1
            181 180 182 1
            182 180 183 1 #Down
            183 181 184 1
            184 182 185 1
            185 182 186 2
            186 183 187 1
            187 183 188 1
            188 184 189 1
            189 185 190 1
            190 190 191 1
            191 190 192 1 #Up
            192 191 193 1
            193 191 194 2
            194 192 195 1
            195 193 196 1
            196 193 197 1
            197 195 198 2
            198 195 199 1
            199 196 200 1
            200 196 201 1 #Up
            201 197 202 1
            202 198 203 1
            203 199 204 2
            204 201 205 1
            205 201 206 2
            206 203 207 2
            207 207 208 1
            208   6   7 1
            209   9  11 1
            210  54  61 1
            211  55  57 1
            212  70  71 1
            213 131 137 2
            214 158 160 1
            215 200 202 1
            216 204 207 1
            217 209 210 1
            218 210 211 1
            219 210 212 2
BRACKET     1    53.2700  -24.5000   53.2700  -21.0000
            1    58.8000  -21.0000   58.8000  -24.5000
            1  x
 ORIGINAL  1  209 210 211 212
 REPEAT    1

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