KEGG   DRUG: Hydroxychloroquine sulfate
Entry
D02114                      Drug                                   
Name
Hydroxychloroquine sulfate (JAN/USP);
Plaquenil (TN)
Product
  Generic
HYDROXYCHLOROQUINE SULFATE (A-S Medication Solutions), HYDROXYCHLOROQUINE SULFATE (A-S Medication Solutions), HYDROXYCHLOROQUINE SULFATE (A-S Medication Solutions), HYDROXYCHLOROQUINE SULFATE (A-S Medication Solutions), HYDROXYCHLOROQUINE SULFATE (A-S Medication Solutions), HYDROXYCHLOROQUINE SULFATE (A-S Medication Solutions), HYDROXYCHLOROQUINE SULFATE (Accord Healthcare), HYDROXYCHLOROQUINE SULFATE (American Health Packaging), HYDROXYCHLOROQUINE SULFATE (Amneal Pharmaceuticals NY LLC), HYDROXYCHLOROQUINE SULFATE (Amneal Pharmaceuticals NY LLC), HYDROXYCHLOROQUINE SULFATE (Aphena Pharma Solutions - Tennessee), HYDROXYCHLOROQUINE SULFATE (Aphena Pharma Solutions - Tennessee), HYDROXYCHLOROQUINE SULFATE (Aphena Pharma Solutions - Tennessee), HYDROXYCHLOROQUINE SULFATE (Aphena Pharma Solutions - Tennessee), HYDROXYCHLOROQUINE SULFATE (AvPAK), HYDROXYCHLOROQUINE SULFATE (Bayshore Pharmaceuticals LLC), HYDROXYCHLOROQUINE SULFATE (Bryant Ranch Prepack), HYDROXYCHLOROQUINE SULFATE (Bryant Ranch Prepack), HYDROXYCHLOROQUINE SULFATE (Bryant Ranch Prepack), HYDROXYCHLOROQUINE SULFATE (Bryant Ranch Prepack), HYDROXYCHLOROQUINE SULFATE (Cardinal Health), HYDROXYCHLOROQUINE SULFATE (Cardinal Health 107), HYDROXYCHLOROQUINE SULFATE (DOH CENTRAL PHARMACY), HYDROXYCHLOROQUINE SULFATE (Dr. Reddy's Laboratories), HYDROXYCHLOROQUINE SULFATE (Jubilant Cadista Pharmaceuticals), HYDROXYCHLOROQUINE SULFATE (Laurus Labs Limited), HYDROXYCHLOROQUINE SULFATE (Major Pharmaceuticals), HYDROXYCHLOROQUINE SULFATE (McKesson Corporation dba SKY Packaging), HYDROXYCHLOROQUINE SULFATE (Mylan Pharmaceuticals), HYDROXYCHLOROQUINE SULFATE (NCS HealthCare of KY), HYDROXYCHLOROQUINE SULFATE (Northstar Rx LLC.), HYDROXYCHLOROQUINE SULFATE (NuCare Pharmaceuticals), HYDROXYCHLOROQUINE SULFATE (NuCare Pharmaceuticals), HYDROXYCHLOROQUINE SULFATE (Preferred Pharmaceuticals), HYDROXYCHLOROQUINE SULFATE (Quallent Pharmaceuticals Health LLC), HYDROXYCHLOROQUINE SULFATE (RPK Pharmaceuticals), HYDROXYCHLOROQUINE SULFATE (RedPharm Drug), HYDROXYCHLOROQUINE SULFATE (Rising Pharma Holdings), HYDROXYCHLOROQUINE SULFATE (Sandoz), HYDROXYCHLOROQUINE SULFATE (Sun Pharmaceutical Industries), HYDROXYCHLOROQUINE SULFATE (Teva Pharmaceuticals USA), HYDROXYCHLOROQUINE SULFATE (Zydus Lifesciences Limited), HYDROXYCHLOROQUINE SULFATE (Zydus Pharmaceuticals (USA))
Formula
C18H26ClN3O. H2SO4
Exact mass
433.1438
Mol weight
433.95
Structure
Simcomp
Class
Metabolizing enzyme substrate
 DG02918  CYP2C8 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 3999
ATC code: P01BA02
Chemical structure group: DG01015
Product (DG01015): D02114<JP/US>
Efficacy
Antimalarial
  Disease
Malaria [DS:H00361]
Discoid lupus erythematosus [DS:H01595]
Systemic lupus erythematosus [DS:H00080]
Rheumatoid arthritis [DS:H00630]
Comment
Aminoquinoline derivative
Metabolism
Enzyme: CYP2C8 [HSA:1558], CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
  P01 ANTIPROTOZOALS
   P01B ANTIMALARIALS
    P01BA Aminoquinolines
     P01BA02 Hydroxychloroquine
      D02114  Hydroxychloroquine sulfate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Antiparasitics
  Antiprotozoals
   Hydroxychloroquine
    D02114  Hydroxychloroquine sulfate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D02114  Hydroxychloroquine sulfate (JAN/USP)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02918  CYP2C8 substrate
   DG01015  Hydroxychloroquine
    D02114  Hydroxychloroquine sulfate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG01015  Hydroxychloroquine
     D02114  Hydroxychloroquine sulfate
Antimicrobials [BR:br08307]
 Antiparasitics
  Antmalarials
   Aminoquinoline
    D02114  Hydroxychloroquine sulfate (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02114
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02114
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02918  CYP2C8 substrate
   DG01015  Hydroxychloroquine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG01015  Hydroxychloroquine
Other DBs
CAS: 747-36-4
PubChem: 7849175
LigandBox: D02114
NIKKAJI: J244.815G
LinkDB
KCF data

ATOM        28
            1   S4a S    35.3817  -16.5587
            2   O1d O    33.9825  -16.5587
            3   O1d O    36.7810  -16.5587
            4   O1d O    35.3817  -15.1594
            5   O1d O    35.3817  -17.9579
            6   N1b N    27.9259  -13.6586
            7   C1c C    29.1334  -12.9646
            8   C1b C    30.3405  -13.6644
            9   C1a C    29.1392  -11.5648
            10  C1b C    31.5540  -12.9703
            11  C1b C    32.7552  -13.6703
            12  N1c N    33.9685  -12.9821
            13  C1b C    35.1757  -13.6819
            14  C1b C    33.9743  -11.5822
            15  C1b C    36.3833  -12.9878
            16  C1a C    35.1816  -10.8882
            17  C8y C    27.9236  -15.0841
            18  C8y C    26.6906  -15.7937
            19  C8y C    26.6886  -17.1897
            20  N5x N    27.8966  -17.8895
            21  C8x C    29.1297  -17.1800
            22  C8x C    29.1317  -15.7839
            23  C8x C    25.4815  -15.0956
            24  C8x C    24.2725  -15.7937
            25  C8y C    24.2725  -17.1897
            26  C8x C    25.4815  -17.8878
            27  X   Cl   23.0615  -17.8890
            28  O1a O    37.6097  -13.6988
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     1   5 2
            5     6   7 1
            6     7   8 1
            7     7   9 1
            8     8  10 1
            9    10  11 1
            10   11  12 1
            11   12  13 1
            12   12  14 1
            13   13  15 1
            14   14  16 1
            15    6  17 1
            16   17  18 1
            17   18  19 2
            18   19  20 1
            19   20  21 2
            20   21  22 1
            21   17  22 2
            22   18  23 1
            23   23  24 2
            24   24  25 1
            25   25  26 2
            26   26  19 1
            27   25  27 1
            28   15  28 1

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