KEGG   DRUG: Topotecan hydrochlorideHelp
Entry
D02168                      Drug                                   

Name
Topotecan hydrochloride (USAN);
Nogitecan hydrochloride (JAN);
Hycamtin (TN);
Potactasol (TN)
Product
  Generic
Formula
C23H23N3O5. HCl
Exact mass
457.1404
Mol weight
457.9068
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01529  Topoisomerase inhibitor
  DG01526  Topoisomerase I inhibitor
Transporter substrate
 DG01665  ABCB1 (P-GP) substrate
 DG02920  ABCC4 substrate
 DG01913  ABCG2 (BCRP) substrate
Remark
Therapeutic category: 4240
ATC code: L01XX17
Chemical structure group: DG00725
Product (DG00725): D02168<JP/US>
Efficacy
Antineoplastic, Topoisomerase I inhibitor
  Disease
Small cell lung cancer [DS:H00013]
Ovarian cancer [DS:H00027]
Cervical cancer [DS:H00030]
Comment
Camptothecin [CPD:C01897] derivative
Target
TOP1 [HSA:7150] [KO:K03163]
Metabolism
Transporter: ABCB1 [HSA:5243], ABCG2 [HSA:9429], ABCC4 [HSA:10257]
Interaction
Drug interaction
Structure map
map07042  Antineoplastics - agents from natural products
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX17 Topotecan
      D02168  Topotecan hydrochloride (USAN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Enzyme Inhibitors
   Topotecan
    D02168  Topotecan hydrochloride (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   424  Plant extract preparations
    4240  Plant extract preparations
     D02168  Topotecan hydrochloride (USAN); Nogitecan hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Isomerases (EC5)
   DNA topoisomerase
    TOP1
     D02168  Topotecan hydrochloride (USAN) <JP/US>
Antineoplastics [br08340.html]
 D02168
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02168
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02168
BRITE hierarchy
Other DBs
CAS: 119413-54-6
PubChem: 7849229
ChEMBL: CHEMBL1607
DrugBank: DB01030
LigandBox: D02168
NIKKAJI: J2.173.467E
LinkDB All DBs
KCF data Show

ATOM        32
            1   C8y C    32.0215  -19.7287
            2   C8y C    29.7683  -20.8552
            3   N4y N    30.6133  -19.7285
            4   C1x C    29.7683  -18.6020
            5   C8y C    28.4540  -20.4326
            6   C8y C    28.4540  -19.0244
            7   C8x C    27.2336  -18.3673
            8   N5x N    27.2336  -21.1367
            9   C8y C    26.0131  -20.4796
            10  C8y C    26.0131  -19.0714
            11  C8y C    24.8396  -18.3673
            12  C8y C    23.6191  -19.0714
            13  C8x C    23.6191  -20.4796
            14  C8x C    24.8396  -21.1838
            15  C1b C    24.8396  -17.0060
            16  N1c N    23.6191  -16.3019
            17  C1a C    23.6191  -14.8937
            18  C1a C    22.4456  -17.0060
            19  O1a O    22.3987  -18.4143
            20  O5x O    32.7141  -18.5298
            21  C8y C    32.7340  -20.9631
            22  C1x C    34.1280  -20.9630
            23  C8y C    32.0340  -22.1755
            24  C8x C    30.6115  -22.1758
            25  O7x O    34.8251  -22.1700
            26  C7x C    34.1346  -23.3658
            27  C1z C    32.7215  -23.3659
            28  O6a O    34.8251  -24.5616
            29  C1b C    31.3147  -23.3660
            30  C1a C    30.6287  -24.5679
            31  O1a O    32.7215  -24.7659
            32  X   Cl   36.6837  -19.7288
BOND        35
            1     2   3 1
            2     3   4 1
            3     4   6 1
            4     5   2 1
            5     5   6 2
            6     6   7 1
            7     7  10 2
            8     9   8 2
            9     8   5 1
            10    9  10 1
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15   14   9 1
            16   11  15 1
            17   15  16 1
            18   16  17 1
            19   16  18 1
            20    3   1 1
            21   12  19 1
            22    1  20 2
            23    1  21 1
            24   21  22 1
            25   21  23 2
            26   23  24 1
            27   24   2 2
            28   22  25 1
            29   25  26 1
            30   26  27 1
            31   27  23 1
            32   26  28 2
            33   27  29 1 #Down
            34   29  30 1
            35   27  31 1 #Up

» Japanese version   » Back

DBGET integrated database retrieval system