KEGG   DRUG: LoxapineHelp
Entry
D02340                      Drug                                   

Name
Loxapine (USAN/INN);
Adasuve (TN)
Product
Formula
C18H18ClN3O
Exact mass
327.1138
Mol weight
327.808
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
Enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C07104
ATC code: N05AH01
Chemical structure group: DG00897
Product (DG00897): D02340<US> D00794<US>
Efficacy
Minor tranquilizer, Dopamine D2 receptor antagonist, Serotonin receptor antagonist
  Disease
Schizophrenia [DS:H01649]
Bipolar I disorder [DS:H01653]
Target
DRD2 [HSA:1813] [KO:K04145]
HTR2A [HSA:3356] [KO:K04157]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AH Diazepines, oxazepines and thiazepines
     N05AH01 Loxapine
      D02340  Loxapine (USAN/INN) <US>
USP drug classification [BR:br08302]
 Antipsychotics
  1st Generation/Typical
   Loxapine
    D02340  Loxapine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D02340  Loxapine (USAN/INN) <US>
   Serotonin
    HTR2A
     D02340  Loxapine (USAN/INN) <US>
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D02340
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02340
BRITE hierarchy
Other DBs
CAS: 1977-10-2
PubChem: 7849399
ChEBI: 50841
ChEMBL: CHEMBL831
DrugBank: DB00408
LigandBox: D02340
NIKKAJI: J22.645I
LinkDB All DBs
KCF data Show

ATOM        23
            1   C2y C    14.6234  -16.0394
            2   C8y C    13.7813  -14.9298
            3   C8y C    14.1165  -13.5730
            4   O2x O    15.3775  -12.9949
            5   N2x N    16.0292  -16.0646
            6   C8y C    16.6311  -13.6172
            7   C8y C    16.9176  -14.9859
            8   C8x C    13.1094  -12.6046
            9   C8x C    11.7674  -12.9927
            10  C8y C    11.4322  -14.3495
            11  C8x C    12.4393  -15.3176
            12  C8x C    18.2488  -15.4230
            13  C8x C    19.2930  -14.4886
            14  C8x C    19.0066  -13.1199
            15  C8x C    17.6752  -12.6828
            16  X   Cl   10.0674  -14.7439
            17  N1y N    13.9889  -17.2891
            18  C1x C    12.5873  -17.2891
            19  C1x C    11.8865  -18.5029
            20  N1y N    12.5873  -19.7169
            21  C1x C    13.9889  -19.7169
            22  C1x C    14.6897  -18.5029
            23  C1a C    11.8803  -20.9409
BOND        26
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18   10  16 1
            19    1  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   17  22 1
            26   20  23 1

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