KEGG   DRUG: Artemether and lumefantrineHelp
Entry
D02484            Mixture   Drug                                   

Name
Artemether and lumefantrine;
Coartem (TN)
Product
Formula
C30H32Cl3NO. C16H26O5
Exact mass
825.333
Mol weight
827.3148
Structure
Mol fileKCF fileDB search
Component
Artemether [DR:D02483], Lumefantrine [DR:D03821]
Remark
Therapeutic category: 6419
ATC code: P01BF01
Product: D02484<JP/US>
Efficacy
Antimalarial
  Disease
Malaria infections [DS:H00361]
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
  P01 ANTIPROTOZOALS
   P01B ANTIMALARIALS
    P01BF Artemisinin and derivatives, combinations
     P01BF01 Artemether and lumefantrine
      D02484  Artemether and lumefantrine <JP/US>
USP drug classification [BR:br08302]
 Antiparasitics
  Antiprotozoals
   Artemether/Lumefantrine
    D02484  Artemether and lumefantrine
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  64  Parasitics (systemic)
   641  Antiprotozoans
    6419  Others
     D02484  Artemether and lumefantrine
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02484
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02484
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02484
BRITE hierarchy
Other DBs
CAS: 141204-94-6
PubChem: 17396663
LigandBox: D02484
NIKKAJI: J1.857.386E
LinkDB All DBs
KCF data Show

ATOM        56
            1   C1z C    18.1300  -21.2800
            2   C1y C    16.9400  -21.9800
            3   C1y C    19.3900  -21.9800
            4   C1y C    18.1300  -19.9500
            5   O2x O    16.5900  -21.2100
            6   O2x O    15.6100  -21.4900
            7   O2x O    16.9400  -23.3800
            8   C1y C    19.3900  -23.3800
            9   C1x C    20.5800  -21.3500
            10  C1y C    19.3900  -19.2500
            11  C1x C    17.4300  -18.9000
            12  O2x O    16.5900  -19.8100
            13  C1z C    15.2600  -20.1600
            14  C1y C    18.1300  -24.0800
            15  C1a C    20.5800  -24.0800
            16  C1x C    20.5800  -19.9500
            17  C1a C    19.3900  -17.8500
            18  C1x C    16.0300  -18.9000
            19  C1a C    13.8600  -20.1600
            20  O2a O    18.1300  -25.4800
            21  C1a C    16.9400  -26.1800
            22  C8y C    26.6502  -22.2214
            23  C8y C    27.1089  -23.5442
            24  C8y C    28.5086  -23.5167
            25  C8y C    28.9150  -22.1770
            26  C2y C    27.7665  -21.3765
            27  C8y C    29.4656  -24.5385
            28  C8x C    30.8291  -24.2206
            29  C8y C    31.2355  -22.8809
            30  C8x C    30.2785  -21.8591
            31  C8x C    25.2753  -21.9573
            32  C8y C    24.3592  -23.0159
            33  C8x C    24.8179  -24.3386
            34  C8x C    26.1927  -24.6028
            35  X   Cl   22.9878  -22.7525
            36  X   Cl   32.5822  -22.5669
            37  C2b C    27.8080  -19.9510
            38  C8y C    29.0267  -19.2938
            39  C8x C    30.2469  -20.0462
            40  C8x C    31.4791  -19.3815
            41  C8y C    31.5196  -17.9821
            42  C8x C    30.2993  -17.2297
            43  C8x C    29.0672  -17.8944
            44  X   Cl   32.7332  -17.3273
            45  C1c C    29.0506  -25.9057
            46  O1a O    27.6878  -26.2232
            47  C1b C    30.0043  -26.9244
            48  N1c N    31.3861  -26.6020
            49  C1b C    32.3298  -27.6097
            50  C1b C    31.7906  -25.2679
            51  C1b C    33.1435  -24.9523
            52  C1b C    34.0688  -25.9402
            53  C1a C    35.4452  -25.6188
            54  C1b C    33.7093  -27.2885
            55  C1b C    34.6858  -28.3322
            56  C1a C    36.0776  -28.0079
BOND        62
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Down
            5     2   6 1
            6     2   7 1
            7     3   8 1
            8     3   9 1
            9     4  10 1
            10    4  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    8  15 1 #Up
            15    9  16 1
            16   10  17 1 #Down
            17   11  18 1
            18   13  19 1 #Up
            19   14  20 1 #Up
            20    8  14 1
            21   10  16 1
            22   13  12 1 #Down
            23   13  18 1
            24   20  21 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   22  26 1
            30   24  27 2
            31   27  28 1
            32   28  29 2
            33   29  30 1
            34   25  30 2
            35   22  31 2
            36   31  32 1
            37   32  33 2
            38   33  34 1
            39   23  34 2
            40   32  35 1
            41   29  36 1
            42   26  37 2
            43   37  38 1
            44   38  39 2
            45   39  40 1
            46   40  41 2
            47   41  42 1
            48   42  43 2
            49   38  43 1
            50   41  44 1
            51   27  45 1
            52   45  46 1
            53   45  47 1
            54   47  48 1
            55   48  49 1
            56   48  50 1
            57   50  51 1
            58   51  52 1
            59   52  53 1
            60   49  54 1
            61   54  55 1
            62   55  56 1

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