KEGG   DRUG: Maprotiline
Entry
D02566                      Drug                                   
Name
Maprotiline (USAN)
Formula
C20H23N
Exact mass
277.1831
Mol weight
277.4033
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01730  Non-selective monoamine reuptake inhibitor
 DG01729  Tetracyclic antidepressant
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C07107
ATC code: N06AA21
Chemical structure group: DG00941
Product (DG00941): D00818<JP>
Efficacy
Antidepressant, Selective noradrenaline reuptake inhibitor (NRI)
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04721  Synaptic vesicle cycle
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA21 Maprotiline
      D02566  Maprotiline (USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01730  Non-selective monoamine reuptake inhibitor
   DG00941  Maprotiline
    D02566  Maprotiline
  DG01729  Tetracyclic antidepressant
   DG00941  Maprotiline
    D02566  Maprotiline
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00941  Maprotiline
    D02566  Maprotiline
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D02566  Maprotiline (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02566
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01730  Non-selective monoamine reuptake inhibitor
   DG00941  Maprotiline
  DG01729  Tetracyclic antidepressant
   DG00941  Maprotiline
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00941  Maprotiline
Other DBs
CAS: 10262-69-8
PubChem: 17396737
ChEBI: 6690
LigandBox: D02566
NIKKAJI: J9.818C
LinkDB
KCF data

ATOM        21
            1   C1x C    21.9568  -16.7489
            2   C1x C    21.9568  -17.8749
            3   C1z C    21.4642  -15.8341
            4   C8y C    20.1975  -16.5378
            5   C8y C    22.7309  -16.5378
            6   C1b C    21.4642  -14.3563
            7   C8y C    20.1975  -17.9452
            8   C8x C    19.0012  -15.7637
            9   C8y C    22.7309  -18.0156
            10  C8x C    23.9976  -15.8341
            11  C1b C    22.7309  -13.6525
            12  C1y C    21.4642  -18.7193
            13  C8x C    18.9308  -18.6490
            14  C8x C    17.7345  -16.4674
            15  C8x C    23.9272  -18.7193
            16  C8x C    25.2643  -16.6082
            17  C1b C    23.9272  -14.4266
            18  C8x C    17.7345  -17.9452
            19  C8x C    25.2643  -18.0156
            20  N1b N    25.2643  -13.7229
            21  C1a C    26.5310  -14.4266
BOND        24
            1     1   2 1
            2     3   4 1
            3     3   5 1
            4     3   6 1
            5     4   7 1
            6     4   8 2
            7     5   9 2
            8     5  10 1
            9     6  11 1
            10    7  12 1
            11    7  13 2
            12    8  14 1
            13    9  15 1
            14   10  16 2
            15   11  17 1
            16   13  18 1
            17   15  19 2
            18   17  20 1
            19   20  21 1
            20    9  12 1
            21   14  18 2
            22   16  19 1
            23    2  12 1
            24    1   3 1

» Japanese version   » Back

KEGG   DRUG: Maprotiline hydrochloride
Entry
D00818                      Drug                                   
Name
Maprotiline hydrochloride (JP18/USP);
Ludiomil (TN)
Formula
C20H23N. HCl
Exact mass
313.1597
Mol weight
313.8643
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01730  Non-selective monoamine reuptake inhibitor
 DG01729  Tetracyclic antidepressant
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Therapeutic category: 1179
ATC code: N06AA21
Chemical structure group: DG00941
Product (DG00941): D00818<JP>
Efficacy
Antidepressant, Selective noradrenaline reuptake inhibitor (NRI)
  Disease
Major depressive disorder [DS:H01646]
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04721  Synaptic vesicle cycle
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA21 Maprotiline
      D00818  Maprotiline hydrochloride (JP18/USP) <JP>
USP drug classification [BR:br08302]
 Antidepressants
  Antidepressants, Other
   Maprotiline
    D00818  Maprotiline hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00818  Maprotiline hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01730  Non-selective monoamine reuptake inhibitor
   DG00941  Maprotiline
    D00818  Maprotiline hydrochloride
  DG01729  Tetracyclic antidepressant
   DG00941  Maprotiline
    D00818  Maprotiline hydrochloride
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00941  Maprotiline
    D00818  Maprotiline hydrochloride
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01730  Non-selective monoamine reuptake inhibitor
   D00818  Maprotiline hydrochloride
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D00818  Maprotiline hydrochloride (JP18/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00818  Maprotiline hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00818
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01730  Non-selective monoamine reuptake inhibitor
   DG00941  Maprotiline
  DG01729  Tetracyclic antidepressant
   DG00941  Maprotiline
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00941  Maprotiline
Other DBs
CAS: 10347-81-6
PubChem: 7847883
ChEBI: 6691
LigandBox: D00818
NIKKAJI: J245.033J
LinkDB
KCF data

ATOM        22
            1   X   Cl   29.2600  -16.5200
            2   C1x C    20.3000  -16.7300
            3   C1x C    20.3000  -17.8500
            4   C1z C    19.8100  -15.8200
            5   C8y C    18.5500  -16.5200
            6   C8y C    21.0700  -16.5200
            7   C1b C    19.8100  -14.3500
            8   C8y C    18.5500  -17.9200
            9   C8x C    17.3600  -15.7500
            10  C8y C    21.0700  -17.9900
            11  C8x C    22.3300  -15.8200
            12  C1b C    21.0700  -13.6500
            13  C1y C    19.8100  -18.6900
            14  C8x C    17.2900  -18.6200
            15  C8x C    16.1000  -16.4500
            16  C8x C    22.2600  -18.6900
            17  C8x C    23.5200  -16.5900
            18  C1b C    22.2600  -14.4200
            19  C8x C    16.1000  -17.9200
            20  C8x C    23.5200  -17.9900
            21  N1b N    23.5200  -13.7200
            22  C1a C    24.7800  -14.4200
BOND        24
            1     2   3 1
            2     4   5 1
            3     4   6 1
            4     4   7 1
            5     5   8 1
            6     5   9 2
            7     6  10 2
            8     6  11 1
            9     7  12 1
            10    8  13 1
            11    8  14 2
            12    9  15 1
            13   10  16 1
            14   11  17 2
            15   12  18 1
            16   14  19 1
            17   16  20 2
            18   18  21 1
            19   21  22 1
            20   10  13 1
            21   15  19 2
            22   17  20 1
            23    3  13 1
            24    2   4 1

» Japanese version   » Back

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