KEGG   DRUG: Articaine hydrochloride
Entry
D02991                      Drug                                   

Name
Articaine hydrochloride (JAN/USP)
Formula
C13H20N2O3S. HCl
Exact mass
320.0961
Mol weight
320.8354
Structure
Simcomp
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01673  Amide type local anesthetic
Remark
ATC code: N01BB08
Chemical structure group: DG00805
Product (mixture): D11290<US>
Efficacy
Anesthetic (local)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB08 Articaine
      D02991  Articaine hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN2A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN3A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN4A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN5A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN8A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN9A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN10A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN11A
     D02991  Articaine hydrochloride (JAN/USP)
Other DBs
CAS: 23964-57-0
PubChem: 17397147
ChEMBL: CHEMBL1200819
LigandBox: D02991
NIKKAJI: J369.157H
LinkDB
KCF data

ATOM        20
            1   X   Cl   30.1700  -17.8500
            2   C8y C    18.9700  -17.9900
            3   C8y C    20.4400  -17.9900
            4   C8y C    20.8600  -16.6600
            5   S2x S    19.7400  -15.8200
            6   C8x C    18.5500  -16.6600
            7   N1b N    21.2800  -19.1100
            8   C7a C    22.1900  -16.2400
            9   O6a O    23.1000  -17.0100
            10  O7a O    22.4700  -14.8400
            11  C1a C    23.8000  -14.4200
            12  C1a C    18.1300  -19.1100
            13  C5a C    22.6800  -19.1100
            14  C1c C    23.3800  -20.3224
            15  N1b N    24.7798  -20.3224
            16  O5a O    23.3800  -17.8976
            17  C1a C    22.6896  -21.5179
            18  C1b C    25.4703  -21.5180
            19  C1b C    26.8797  -21.5180
            20  C1a C    27.5677  -22.7095
BOND        19
            1     2   3 1
            2     3   4 2
            3     4   5 1
            4     5   6 1
            5     2   6 2
            6     3   7 1
            7     4   8 1
            8     8   9 2
            9     8  10 1
            10   10  11 1
            11    2  12 1
            12    7  13 1
            13   13  14 1
            14   14  15 1
            15   13  16 2
            16   14  17 1
            17   15  18 1
            18   18  19 1
            19   19  20 1

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