KEGG   DRUG: Atrasentan hydrochloride
Entry
D03009                      Drug                                   
Name
Atrasentan hydrochloride (USAN);
Vanrafia (TN)
Product
VANRAFIA (Novartis Pharmaceuticals Corporation)
Formula
C29H38N2O6. HCl
Exact mass
546.2497
Mol weight
547.08
Structure
Class
Cardiovascular agent
 DG01502  Endothelin receptor antagonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
 DG02924  UGT substrate
Remark
Product: D03009<US>
Efficacy
Antineoplastic, Proteinuria reducer, Endothelin receptor type A antagonist
  Disease
Primary immunoglobulin A nephropathy [DS:H01581]
Comment
Palliative treatment of bone pain due to metastatic prostate cancer and disease progression
Target
EDNRA [HSA:1909] [KO:K04197]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04924  Renin secretion
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551], UGT [KO:K00699]
Interaction
Brite
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01502  Endothelin receptor antagonist
   D03009  Atrasentan hydrochloride
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D03009  Atrasentan hydrochloride
  DG02924  UGT substrate
   D03009  Atrasentan hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Endothelin
    EDNRA
     D03009  Atrasentan hydrochloride (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D03009
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03009
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D03009
Other DBs
CAS: 195733-43-8
PubChem: 17397165
LigandBox: D03009
LinkDB
KCF data

ATOM        38
            1   C1y C    26.0400  -21.0700
            2   C1x C    26.0400  -19.6700
            3   C8y C    22.4000  -21.7700
            4   C8y C    22.4000  -23.1700
            5   C8x C    23.5900  -23.8700
            6   C8x C    24.8500  -23.1700
            7   C8y C    24.8500  -21.7700
            8   C8x C    23.5900  -21.0700
            9   O2x O    21.0700  -21.3500
            10  C1x C    20.2300  -22.4700
            11  O2x O    21.0700  -23.5900
            12  C1y C    27.3700  -21.4900
            13  C1y C    28.2100  -20.3700
            14  N1y N    27.3700  -19.2500
            15  C6a C    27.7900  -22.8200
            16  C8y C    29.6100  -20.3700
            17  O6a O    29.1900  -22.8200
            18  O6a O    26.9500  -23.9400
            19  C8x C    30.3100  -21.5600
            20  C8x C    31.7100  -21.5600
            21  C8y C    32.4100  -20.3700
            22  C8x C    31.7100  -19.1800
            23  C8x C    30.3100  -19.1800
            24  O2a O    33.8100  -20.3700
            25  C1a C    34.5100  -21.5600
            26  C1b C    27.3700  -17.8500
            27  C5a C    26.1576  -17.1500
            28  N1c N    24.9621  -17.8404
            29  O5a O    26.1575  -15.7502
            30  C1b C    23.7747  -17.1549
            31  C1b C    24.9620  -19.2497
            32  C1b C    23.7706  -19.9378
            33  C1b C    22.5855  -19.2536
            34  C1a C    21.3931  -19.9423
            35  C1b C    22.5835  -17.8429
            36  C1b C    21.3940  -17.1562
            37  C1a C    20.2039  -17.8435
            38  X   Cl   32.7600  -24.3600
BOND        40
            1     1   2 1
            2     3   4 2
            3     4   5 1
            4     5   6 2
            5     6   7 1
            6     7   8 2
            7     3   8 1
            8     3   9 1
            9     9  10 1
            10   10  11 1
            11    4  11 1
            12    1   7 1 #Up
            13    1  12 1
            14   12  13 1
            15   13  14 1
            16    2  14 1
            17   12  15 1 #Down
            18   13  16 1 #Up
            19   15  17 1
            20   15  18 2
            21   16  19 2
            22   19  20 1
            23   20  21 2
            24   21  22 1
            25   22  23 2
            26   16  23 1
            27   21  24 1
            28   24  25 1
            29   14  26 1
            30   26  27 1
            31   27  28 1
            32   27  29 2
            33   28  30 1
            34   28  31 1
            35   31  32 1
            36   32  33 1
            37   33  34 1
            38   30  35 1
            39   35  36 1
            40   36  37 1

» Japanese version   » Back

DBGET integrated database retrieval system