KEGG   DRUG: LenalidomideHelp
Entry
D04687                      Drug                                   

Name
Lenalidomide (USAN/INN);
Revlimid (TN)
Product
Formula
C13H13N3O3
Exact mass
259.0957
Mol weight
259.2606
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01936  TNF inhibitor
Remark
ATC code: L04AX04
Chemical structure group: DG00744
Product (DG00744): D04687<US> D09813<JP>
Efficacy
Antineoplastic, Immunomodulator, TNF-alpha inhibitor
  Disease
Multiple myeloma [DS:H00010]
Myelodysplastic syndromes (chromosome 5q deletion) [DS:H01484]
Mantle cell lymphoma [DS:H01464]
Comment
Thalidomide [DR:D00754] derivative
Target
TNF (TNFA, TNFSF2) [HSA:7124] [KO:K03156]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04064  NF-kappa B signaling pathway
hsa04210  Apoptosis
hsa04640  Hematopoietic cell lineage
hsa04650  Natural killer cell mediated cytotoxicity
hsa04668  TNF signaling pathway
Interaction
Drug interaction
Structure map
map07046  Immunosuppressive agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AX Other immunosuppressants
     L04AX04 Lenalidomide
      D04687  Lenalidomide (USAN/INN) <US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antiangiogenic Agents
   Lenalidomide
    D04687  Lenalidomide (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNF (TNFA, TNFSF2)
     D04687  Lenalidomide (USAN/INN) <US>
Antineoplastics [br08340.html]
 D04687
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D04687
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04687
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04687
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D04687
BRITE hierarchy
Other DBs
CAS: 191732-72-6
PubChem: 47206522
ChEBI: 63791
ChEMBL: CHEMBL848
DrugBank: DB00480
LigandBox: D04687
NIKKAJI: J1.121.689G
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8x C    12.8800  -15.7500
            2   C8x C    12.8800  -17.1500
            3   C8x C    14.0924  -17.8500
            4   C8y C    15.3049  -17.1500
            5   C8y C    15.3049  -15.7500
            6   C8y C    14.0924  -15.0500
            7   C5x C    16.6364  -17.5826
            8   N1y N    17.4593  -16.4500
            9   C1x C    16.6364  -15.3174
            10  C1y C    18.8300  -16.4500
            11  O5x O    17.0675  -18.9094
            12  N1a N    14.0924  -13.6502
            13  C1x C    19.5300  -17.6624
            14  C1x C    20.9300  -17.6624
            15  C5x C    21.6300  -16.4500
            16  N1x N    20.9300  -15.2376
            17  C5x C    19.5300  -15.2376
            18  O5x O    18.8396  -14.0421
            19  O5x O    23.0300  -16.4500
BOND        21
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12    7  11 2
            13    6  12 1
            14   10  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   10  17 1
            20   17  18 2
            21   15  19 2

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