| Entry |
|
|---|
| Name |
Imidafenacin (JAN/INN);
Uritos (TN);
Staybla (TN) |
|---|
| Formula |
C20H21N3O
|
|---|
| Exact mass |
319.1685
|
|---|
| Mol weight |
319.4002
|
|---|
| Structure |
|
|---|
| Class |
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02924 UGT substrate
DG03182 UGT1A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 2590 |
|
|---|
| Efficacy |
Overactive bladder agent, Muscarinic acetylcholine receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], UGT1A4 [HSA: 54657]
|
|---|
| Interaction |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
25 Urogenital and anal organ agents
259 Miscellaneous
2590 Miscellaneous
D06273 Imidafenacin (JAN/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM1
D06273 Imidafenacin (JAN/INN) <JP>
CHRM3
D06273 Imidafenacin (JAN/INN) <JP>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D06273
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D06273
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D06273
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 24
1 N5x N 26.6000 -18.6900
2 C8x C 26.9623 -20.1123
3 C8x C 28.3604 -20.1156
4 N4y N 28.8622 -18.8085
5 C8y C 27.7742 -17.9275
6 C1b C 30.0524 -18.1300
7 C1b C 31.2649 -18.8300
8 C1d C 32.4773 -18.1300
9 C8y C 33.6897 -18.8300
10 C8y C 32.4773 -16.7300
11 C8x C 33.6897 -20.2300
12 C8x C 33.6918 -16.0288
13 C8x C 33.6918 -14.6288
14 C8x C 32.4793 -13.9288
15 C8x C 31.2649 -14.6300
16 C8x C 31.2649 -16.0300
17 C8x C 34.9022 -20.9300
18 C8x C 36.1146 -20.2300
19 C8x C 36.1146 -18.8300
20 C8x C 34.9022 -18.1300
21 C5a C 35.5097 -16.4500
22 C1a C 27.7742 -16.5275
23 O5a O 36.6950 -17.1627
24 N1a N 35.4645 -15.0507
BOND 26
1 1 2 1
2 2 3 2
3 3 4 1
4 4 5 1
5 1 5 2
6 4 6 1
7 6 7 1
8 7 8 1
9 8 9 1
10 8 10 1
11 9 11 2
12 10 12 2
13 12 13 1
14 13 14 2
15 14 15 1
16 15 16 2
17 10 16 1
18 11 17 1
19 17 18 2
20 18 19 1
21 19 20 2
22 9 20 1
23 8 21 1
24 5 22 1
25 21 23 2
26 21 24 1
|
|---|
