KEGG   DRUG: Pirmenol hydrochloride
Entry
D06517                      Drug                                   

Name
Pirmenol hydrochloride (USAN);
Pirmavar (TN)
Formula
C22H30N2O. HCl
Exact mass
374.2125
Mol weight
374.9473
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Remark
Chemical structure group: DG01381
Product (DG01381): D01785<JP>
Efficacy
Antiarrhythmic, Cardiac depressant
Comment
Class I antiarrhythmic agent (Ia)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D06517  Pirmenol hydrochloride (USAN)
    SCN2A
     D06517  Pirmenol hydrochloride (USAN)
    SCN3A
     D06517  Pirmenol hydrochloride (USAN)
    SCN4A
     D06517  Pirmenol hydrochloride (USAN)
    SCN5A
     D06517  Pirmenol hydrochloride (USAN)
    SCN8A
     D06517  Pirmenol hydrochloride (USAN)
    SCN9A
     D06517  Pirmenol hydrochloride (USAN)
    SCN10A
     D06517  Pirmenol hydrochloride (USAN)
    SCN11A
     D06517  Pirmenol hydrochloride (USAN)
Other DBs
CAS: 61477-94-9
PubChem: 47208173
LigandBox: D06517
NIKKAJI: J354.310B
LinkDB
KCF data

ATOM        26
            1   C8x C    26.8663  -19.6226
            2   C8x C    26.8663  -21.0243
            3   C8x C    28.0831  -21.7251
            4   C8x C    29.2928  -21.0243
            5   C8y C    29.2928  -19.6226
            6   C8x C    28.0831  -18.9218
            7   C1d C    30.5072  -18.9228
            8   C8y C    31.7206  -19.6245
            9   C8x C    31.7140  -21.0241
            10  C8x C    32.9274  -21.7260
            11  C8x C    34.1417  -21.0260
            12  C8x C    34.1427  -19.6243
            13  N5x N    32.9295  -18.9226
            14  C1b C    30.5050  -17.5273
            15  C1b C    31.7155  -16.8265
            16  C1b C    31.7155  -15.4319
            17  N1y N    32.9261  -14.7311
            18  C1y C    34.1383  -15.4290
            19  C1x C    35.3489  -14.7282
            20  C1x C    35.3472  -13.3294
            21  C1x C    34.1349  -12.6315
            22  C1y C    32.9244  -13.3323
            23  C1a C    31.7096  -12.6328
            24  C1a C    34.1400  -16.8307
            25  O1a O    29.2948  -18.2228
            26  X   Cl   37.2767  -18.6182
BOND        27
            1    11  12 1
            2    12  13 2
            3    13   8 1
            4     6   1 1
            5     7  14 1
            6    14  15 1
            7     5   7 1
            8    15  16 1
            9    16  17 1
            10    7   8 1
            11    1   2 2
            12    2   3 1
            13    3   4 2
            14    4   5 1
            15    5   6 2
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19   20  21 1
            20   21  22 1
            21   22  17 1
            22    8   9 2
            23   22  23 1 #Down
            24    9  10 1
            25   18  24 1 #Down
            26   10  11 2
            27    7  25 1

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