KEGG   DRUG: Lacosamide
Entry
D07299                      Drug                                   

Name
Lacosamide (JAN/USAN/INN);
Erlosamide;
Vimpat (TN)
Product
Formula
C13H18N2O3
Exact mass
250.1317
Mol weight
250.2936
Structure
Class
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG01933  CYP2C19 inhibitor
Remark
Therapeutic category: 1139
ATC code: N03AX18
Product: D07299<JP/US>
Efficacy
Antiepileptic, Pain relief (neuropathic)
Comment
Treatment of epilepsy and neuropathic pain
Target
SCN3A [HSA:6328] [KO:K04836]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C9 [HSA:1559], CYP2C19 [HSA:1557]
Interaction
CYP inhibition: CYP2C19 [HSA:1557]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX18 Lacosamide
      D07299  Lacosamide (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Lacosamide
    D07299  Lacosamide (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D07299  Lacosamide (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN3A
     D07299  Lacosamide (JAN/USAN/INN) <JP/US>
    SCN9A
     D07299  Lacosamide (JAN/USAN/INN) <JP/US>
    SCN10A
     D07299  Lacosamide (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D07299
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D07299
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D07299
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D07299
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07299
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D07299
Other DBs
CAS: 175481-36-4
PubChem: 51091636
ChEMBL: CHEMBL58323
LigandBox: D07299
LinkDB
KCF data

ATOM        18
            1   C8y C    21.1332  -17.9117
            2   C1b C    22.3451  -17.2121
            3   N1b N    23.5571  -17.9117
            4   C5a C    24.7689  -17.2121
            5   C1c C    25.9808  -17.9117
            6   C1b C    27.1927  -17.2121
            7   O2a O    28.4046  -17.9117
            8   C8x C    19.9214  -17.2121
            9   C8x C    18.7094  -17.9117
            10  C8x C    18.7094  -19.3111
            11  C8x C    19.9214  -20.0108
            12  C8x C    21.1332  -19.3111
            13  O5a O    24.7689  -15.8127
            14  N1b N    25.9808  -19.3110
            15  C1a C    29.6205  -17.2098
            16  C5a C    24.7564  -20.0179
            17  C1a C    23.5627  -19.3285
            18  O5a O    24.7562  -21.4198
BOND        18
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     1   8 2
            8     8   9 1
            9     9  10 2
            10   10  11 1
            11   11  12 2
            12    1  12 1
            13    4  13 2
            14    5  14 1 #Up
            15    7  15 1
            16   14  16 1
            17   16  17 1
            18   16  18 2

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