KEGG   DRUG: LacosamideHelp
Entry
D07299                      Drug                                   

Name
Lacosamide (JAN/USAN/INN);
Erlosamide;
Vimpat (TN)
Product
  Generic
Formula
C13H18N2O3
Exact mass
250.1317
Mol weight
250.2936
Structure
Mol fileKCF fileDB search
Class
Enzyme substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
Enzyme inhibitor
 DG01933  CYP2C19 inhibitor
Remark
Therapeutic category: 1139
ATC code: N03AX18
Product: D07299<JP/US>
Efficacy
Antiepileptic, Pain relief (neuropathic)
Comment
Treatment of epilepsy and neuropathic pain
Target
SCN3A [HSA:6328] [KO:K04836]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C9 [HSA:1559], CYP2C19 [HSA:1557]
Interaction
CYP inhibition: CYP2C19 [HSA:1557]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX18 Lacosamide
      D07299  Lacosamide (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Lacosamide
    D07299  Lacosamide (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D07299  Lacosamide (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN3A
     D07299  Lacosamide (JAN/USAN/INN) <JP/US>
    SCN9A
     D07299  Lacosamide (JAN/USAN/INN) <JP/US>
    SCN10A
     D07299  Lacosamide (JAN/USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D07299
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D07299
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D07299
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D07299
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D07299
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and germline mutations
  D07299
BRITE hierarchy
Other DBs
CAS: 175481-36-4
PubChem: 51091636
ChEMBL: CHEMBL58323
LigandBox: D07299
LinkDB All DBs
KCF data Show

ATOM        18
            1   C8y C    21.1332  -17.9117
            2   C1b C    22.3451  -17.2121
            3   N1b N    23.5571  -17.9117
            4   C5a C    24.7689  -17.2121
            5   C1c C    25.9808  -17.9117
            6   C1b C    27.1927  -17.2121
            7   O2a O    28.4046  -17.9117
            8   C8x C    19.9214  -17.2121
            9   C8x C    18.7094  -17.9117
            10  C8x C    18.7094  -19.3111
            11  C8x C    19.9214  -20.0108
            12  C8x C    21.1332  -19.3111
            13  O5a O    24.7689  -15.8127
            14  N1b N    25.9808  -19.3110
            15  C1a C    29.6205  -17.2098
            16  C5a C    24.7564  -20.0179
            17  C1a C    23.5627  -19.3285
            18  O5a O    24.7562  -21.4198
BOND        18
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     1   8 2
            8     8   9 1
            9     9  10 2
            10   10  11 1
            11   11  12 2
            12    1  12 1
            13    4  13 2
            14    5  14 1 #Up
            15    7  15 1
            16   14  16 1
            17   16  17 1
            18   16  18 2

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