KEGG   DRUG: ArticaineHelp
Entry
D07468                      Drug                                   

Name
Articaine (INN);
Carticaine
Formula
C13H20N2O3S
Exact mass
284.1195
Mol weight
284.3745
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01673  Amide type local anesthetic
 DG01675  Local anesthetic
  DG01673  Amide type local anesthetic
Remark
ATC code: N01BB08
Chemical structure group: DG00805
Efficacy
Anesthetic (local)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB08 Articaine
      D07468  Articaine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D07468  Articaine (INN)
    SCN2A
     D07468  Articaine (INN)
    SCN3A
     D07468  Articaine (INN)
    SCN4A
     D07468  Articaine (INN)
    SCN5A
     D07468  Articaine (INN)
    SCN8A
     D07468  Articaine (INN)
    SCN9A
     D07468  Articaine (INN)
    SCN10A
     D07468  Articaine (INN)
    SCN11A
     D07468  Articaine (INN)
BRITE hierarchy
Other DBs
CAS: 23964-58-1
PubChem: 51091796
ChEMBL: CHEMBL1093
LigandBox: D07468
NIKKAJI: J342.299B
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8y C    20.2300  -17.3600
            2   C8y C    21.7000  -17.3600
            3   C8y C    22.1200  -16.0300
            4   S2x S    21.0000  -15.1900
            5   C8x C    19.8100  -16.0300
            6   N1b N    22.5400  -18.4800
            7   C7a C    23.5200  -15.6100
            8   O6a O    24.4300  -16.3800
            9   O7a O    23.8000  -14.2100
            10  C1a C    25.1300  -13.7900
            11  C1a C    19.3900  -18.4800
            12  C5a C    24.0100  -18.4800
            13  C1c C    24.7100  -19.7400
            14  N1b N    26.1100  -19.7400
            15  O5a O    24.7100  -17.2900
            16  C1a C    24.0100  -20.9300
            17  C1b C    26.8100  -20.9300
            18  C1b C    28.2100  -20.9300
            19  C1a C    28.9100  -22.1200
BOND        19
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 1
            5     1   5 2
            6     2   6 1
            7     3   7 1
            8     7   8 2
            9     7   9 1
            10    9  10 1
            11    1  11 1
            12    6  12 1
            13   12  13 1
            14   13  14 1
            15   12  15 2
            16   13  16 1
            17   14  17 1
            18   17  18 1
            19   18  19 1

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